Patents by Inventor Akiyoshi Saitoh

Akiyoshi Saitoh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10442802
    Abstract: A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(?O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: October 15, 2019
    Assignee: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Hiroshi Nagase, Hideaki Fujii, Akiyoshi Saitoh, Eriko Nakata, Masaaki Hirose, Isao Ooi, Kohei Hayashida
  • Publication number: 20180057493
    Abstract: A morphinan derivative represented by the following general formula (I): (wherein R1 represents hydrogen, C1-10 alkyl, cycloalkylalkyl where the cycloalkyl moiety has 3 to 6 carbon atoms, and the alkylene moiety has 1 to 5 carbon atoms, etc., R2 represents heterocyclic ring containing 1 to 4 heteroatoms selected from N, O and S and at least one carbon atom as ring-constituting atoms, containing at least one set of adjacent ring-constituting atoms bound by a double bond, and further substituted with at least one oxo group, Y binds to a carbon atom as a ring-constituting atom of R2, R3, R4, and R5 represent hydrogen; hydroxy, etc., R6a and R6b represent hydrogen, etc., R7 and R8 represent hydrogen, etc., R9 and R10, which are the same or different, represent hydrogen, etc., X represents O or CH2, and Y represents C(?O)), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof is used as an anxiolytic drug, antidepressant, etc.
    Type: Application
    Filed: March 17, 2016
    Publication date: March 1, 2018
    Applicants: UNIVERSITY OF TSUKUBA, SCHOOL JURIDICAL PERSON KITASATO INSTITUTE, NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY, NIPPON CHEMIPHAR CO., LTD.
    Inventors: Hiroshi NAGASE, Hideaki FUJII, Akiyoshi SAITOH, Eriko NAKATA, Masaaki HIROSE, Isao OOI, Kohei HAYASHIDA
  • Patent number: 7004816
    Abstract: A grinding method for a vertical type of double disk surface grinding machine comprising a pair of rotating grinding wheels vertically opposed to each other and vertically movable and a moving table for moving a work having a work holding jig, wherein vertical positions of the upper and the lower surfaces of the work to be ground prior to the grinding operation are measured by means of a pre-grinding dimension measuring instrument disposed in a vicinity of the work attaching/detaching position and the standby positions of the grinding wheels are set based on the measured values in a step, the work is moved to the grinding position and the grinding wheels are moved at a high feeding speed from the set standby positions to grinding start positions in contact with the work or positions immediately before making the contact in a subsequent step, and the work is ground at a grinding speed lower than the feeding speed in a further subsequent step.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: February 28, 2006
    Assignee: Daisho Seiki Corporation
    Inventor: Akiyoshi Saitoh
  • Patent number: 6932685
    Abstract: A vertical type of double disc surface grinding machine of the present invention comprises a clamp device which can clamps and holds a work like a brake disc at a correct clamping position under a stable state even when a configuration of a work upper surface is complicated. This machine is equipped with a pair of upper and lower grinding wheels, a work holding jig which is self rotatable, and said clamp device. The clamp device is equipped with a clamp unit freely rotatable through a bearing onto a clamp rod of an elevator actuator. The clamp unit is equipped with a steel ball contacting with a central concave portion of a work upper surface.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: August 23, 2005
    Assignee: Daisho Seiki Corporation
    Inventor: Akiyoshi Saitoh
  • Publication number: 20050148286
    Abstract: A grinding method for a vertical type of double disk surface grinding machine comprising a pair of rotating grinding wheels vertically opposed to each other and vertically movable and a moving table for moving a work having a work holding jig, wherein vertical positions of the upper and the lower surfaces of the work to be ground prior to the grinding operation are measured by means of a pre-grinding dimension measuring instrument disposed in a vicinity of the work attaching/detaching position and the standby positions of the grinding wheels are set based on the measured values in a step, the work is moved to the grinding position and the grinding wheels are moved at a high feeding speed from the set standby positions to grinding start positions in contact with the work or positions immediately before making the contact in a subsequent step, and the work is ground at a grinding speed lower than the feeding speed in a further subsequent step.
    Type: Application
    Filed: March 7, 2005
    Publication date: July 7, 2005
    Applicant: Daisho Seiki Corporation
    Inventor: Akiyoshi Saitoh
  • Patent number: 6896598
    Abstract: In a vertical type of double disc surface grinding machine, an object of this invention is to enable simple adjustment of a parallelism between a grinding surface of a lower grinding wheel and a work end face clamped by a clamping jig of a rotary table, even when a grinding wheel spindle axis is disordered. The vertical type of double disc surface grinding machine is equipped with a pair of grinding wheels 2 & 3 opposing each other in vertical direction and fixed to a pair of vertical grinding wheels 4 & 5 and a rotary table 15 holding a work W and supplying it to a grinding position A1 located between the grinding wheels 2 & 3, and provided on the rotary table 15 with a work clamping jig 17 including a rotary shaft 63 which clamps the work W at a specified position and makes it spin itself.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: May 24, 2005
    Assignee: Daisho Seiki Corporation
    Inventor: Akiyoshi Saitoh
  • Patent number: 6881133
    Abstract: A double surface grinding method for a vertical type of double disc surface grinding machine in which upper and lower ground surfaces of a work like a disc brake are ground simultaneously. The entire vertical moving stroke of the grinding wheel includes an idle feed stroke in which the wheel moves at a specified idle feed speed from the waiting position to a detection start position before contacting with the ground surface; a detection stroke in which the wheel moves at a detection speed lower than the idle feed speed from the detection start position to a detection end position after contacting with the ground surface then the wheel detects a grinding start position; and a grinding stroke in which the wheel moves at a grinding speed from the grinding start position to a grinding end position.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: April 19, 2005
    Assignee: Daisho Seiki Corporation
    Inventors: Akiyoshi Saitoh, Masahiko Hamada
  • Publication number: 20050064801
    Abstract: In a vertical type of double disc surface grinding machine, an object of this invention is to enable simple adjustment of a parallelism between a grinding surface of a lower grinding wheel and a work end face clamped by a clamping jig of a rotary table, even when a grinding wheel spindle axis is disordered. The vertical type of double disc surface grinding machine is equipped with a pair of grinding wheels 2 & 3 opposing each other in vertical direction and fixed to a pair of vertical grinding wheels 4 & 5 and a rotary table 15 holding a work W and supplying it to a grinding position A1 located between the grinding wheels 2 & 3, and provided on the rotary table 15 with a work clamping jig 17 including a rotary shaft 63 which clamps the work W at a specified position and makes it spin itself.
    Type: Application
    Filed: April 30, 2004
    Publication date: March 24, 2005
    Applicant: Daisho Seiki Corporation
    Inventor: Akiyoshi Saitoh
  • Publication number: 20040067722
    Abstract: In a vertical type of double disc surface grinding machine, an object of this invention is to enable simple adjustment of a parallelism between a grinding surface of a lower grinding wheel and a work end face clamped by a clamping jig of a rotary table, even when a grinding wheel spindle axis is disordered. The vertical type of double disc surface grinding machine is equipped with a pair of grinding wheels 2 & 3 opposing each other in vertical direction and fixed to a pair of vertical grinding wheels 4 & 5 and a rotary table 15 holding a work W and supplying it to a grinding position A1 located between the grinding wheels 2 & 3, and provided on the rotary table 15 with a work clamping jig 17 including a rotary shaft 63 which clamps the work W at a specified position and makes it spin itself.
    Type: Application
    Filed: October 8, 2002
    Publication date: April 8, 2004
    Applicant: Daisho Seiki Corporation
    Inventor: Akiyoshi Saitoh
  • Publication number: 20040029500
    Abstract: A double surface grinding method for a vertical type of double disc surface grinding machine in which upper and lower ground surfaces of a work like a disc brake are ground simultaneously. The entire vertical moving stroke of the grinding wheel includes an idle feed stroke in which the wheel moves at a specified idle feed speed from the waiting position to a detection start position before contacting with the ground surface; a detection stroke in which the wheel moves at a detection speed lower than the idle feed speed from the detection start position to a detection end position after contacting with the ground surface then the wheel detects a grinding start position; and a grinding stroke in which the wheel moves at a grinding speed from the grinding start position to a grinding end position.
    Type: Application
    Filed: May 16, 2003
    Publication date: February 12, 2004
    Applicant: Daisho Seiki Corporation
    Inventors: Akiyoshi Saitoh, Masahiko Hamada
  • Publication number: 20040014407
    Abstract: A vertical type of double disc surface grinding machine of the present invention comprises a clamp device which can clamps and holds a work like a brake disc at a correct clamping position under a stable state even when a configuration of a work upper surface is complicated. This machine is equipped with a pair of upper and lower grinding wheels, a work holding jig which is self rotatable, and said clamp device. The clamp device is equipped with a clamp unit freely rotatable through a bearing onto a clamp rod of an elevator actuator. The clamp unit is equipped with a steel ball contacting with a central concave portion of a work upper surface.
    Type: Application
    Filed: May 16, 2003
    Publication date: January 22, 2004
    Applicant: Daisho Seiki Corporation
    Inventor: Akiyoshi Saitoh
  • Publication number: 20030166656
    Abstract: A drug for curing or preventing mood disorder or anxiety disorder that has fewer and milder side effects comprising, as an effective component, an isoquinoline derivative or a physiologically acceptable acid addition salt thereof, the representative example of the isoquinoline derivative being (4aS, 12aS)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydroquinolino [2,3-g]isoquinoline; a method for curing or preventing mood disorder or anxiety disorder using the same; and a use of the isoquinoline derivative or the physiologically acceptable acid addition salt thereof for the manufacture of a medicament for curing or preventing mood disorder and anxiety disorder.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 4, 2003
    Inventors: Hiroshi Nagase, Toshiaki Tanaka, Akiyoshi Saitoh