Patents by Inventor Alan A. Melcher
Alan A. Melcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230173048Abstract: The present invention provides an anti-cancer vaccine comprising: (i) at least one peptide comprising the amino acid sequence of a neoantigen encoded by a mutant homologous recombination (HR) DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D, wherein the mutant gene comprises a reversion mutation; and/or (ii) at least one polynucleotide encoding the at least one peptide of (i). Also provided are engineered T cells that recognise said neoantigen. Related methods and medical uses of the vaccine and/or engineered T cell are provided, including for the treatment of cancers, such as homologous recombination (HR) deficient cancers that acquire PARP inhibitor resistance or platinum resistance by development of reversion mutations in an HR DNA repair gene selected from the group: BRCA1, BRCA2, PALB2, CDK12, RAD51B, RAD51C and RAD51D.Type: ApplicationFiled: April 28, 2021Publication date: June 8, 2023Applicant: The Institute of Cancer Research: Royal Cancer HospitalInventors: Stephen Pettitt, Christopher Lord, Marco Punta, Alan Melcher
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Publication number: 20210369824Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: ApplicationFiled: November 4, 2020Publication date: December 2, 2021Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10849964Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: GrantFiled: June 18, 2018Date of Patent: December 1, 2020Assignees: Mayo Foundation for Medical Education and Research, Leeds UniversityInventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10441643Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.Type: GrantFiled: March 19, 2015Date of Patent: October 15, 2019Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Rosa Maria Diaz, Christine Marie Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10391159Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.Type: GrantFiled: December 5, 2018Date of Patent: August 27, 2019Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Publication number: 20190167773Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.Type: ApplicationFiled: December 5, 2018Publication date: June 6, 2019Applicants: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10188713Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.Type: GrantFiled: March 19, 2015Date of Patent: January 29, 2019Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Publication number: 20190015489Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: ApplicationFiled: June 18, 2018Publication date: January 17, 2019Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 10029003Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: GrantFiled: November 22, 2016Date of Patent: July 24, 2018Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Patent number: 10022431Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: GrantFiled: February 10, 2011Date of Patent: July 17, 2018Assignees: Mayo Foundation for Medical Education and Research, Leeds UniversityInventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan Melcher, Peter Selby
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Publication number: 20170143813Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: ApplicationFiled: November 22, 2016Publication date: May 25, 2017Inventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Publication number: 20170080065Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-lla antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.Type: ApplicationFiled: March 19, 2015Publication date: March 23, 2017Applicants: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Rosa Maria Diaz, Christine Marie Pulido, Alan A. Melcher, Peter Selby
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Publication number: 20170080066Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.Type: ApplicationFiled: March 19, 2015Publication date: March 23, 2017Applicants: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
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Patent number: 9517258Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: GrantFiled: March 15, 2013Date of Patent: December 13, 2016Assignees: Mayo Foundation for Medical Education and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Publication number: 20150064218Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors within a mammal (e.g., a human) are provided.Type: ApplicationFiled: March 15, 2013Publication date: March 5, 2015Applicants: Mayo Foundation for Medical and Research, University of LeedsInventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Alan A. Melcher, Peter Selby
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Publication number: 20120308601Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.Type: ApplicationFiled: February 10, 2011Publication date: December 6, 2012Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan Melcher, Peter Selby
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Publication number: 20100292309Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials that include using CD40L polypeptide, an hsp70 polypeptide, and a cytotoxic polypeptide to trigger an immune response directed against cancer cells are provided.Type: ApplicationFiled: March 7, 2008Publication date: November 18, 2010Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Jill M. Thompson, Alan Melcher
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Publication number: 20020042127Abstract: Disclosed is a cell which expresses a surface marker associated with a professional antigen presenting cell, and a fusogenic membrane protein, where the cell may also express at its surface a tumor cell marker. Also disclosed is a fusion hybrid formed by the fusion of a tumor cell and a professional antigen presenting cell (APC) such that the resulting fusion hybrid expresses an APC marker, a tumor cell marker, and a fusogenic membrane glycoprotein. Also disclosed are compositions comprising the cells and fusion hybrids, and methods of making and using the hybrids.Type: ApplicationFiled: November 22, 1999Publication date: April 11, 2002Inventors: STEPHEN JAMES RUSSELL, RICHARD VILE, ANDREW BATEMAN, ALAN MELCHER