Patents by Inventor Alan L. Huston

Alan L. Huston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11287430
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: March 29, 2022
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Patent number: 11029428
    Abstract: Compositions including additive manufacturing materials incorporating radiological detection materials therein are provided. Also provided are apparatus and methods, which may be utilized to monitor and measure nuclear criticality events, and determine if personnel have been exposed to ionizing radiation. The compositions, apparatus, and methods beneficially improve accuracy in assessing radiation exposure, particularly neutron exposure, and reduce degradation of the radiological detection materials.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: June 8, 2021
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Luis A. Benevides, Alan L. Huston, Brian L. Justus, Barbara A. Marcheschi
  • Patent number: 11028016
    Abstract: A method of making a copper-doped glass comprising placing a target glass in a container, placing a target glass in a container, surrounding the target glass with a powder mixture comprised of fused silica (SiO2) powder and copper sulfide (Cu2S) powder, such that both the target glass and the surrounding powder are contained in the container, and heating the container and the target glass and the surrounding powder mixture to a temperature of between 800° C. and 1150° C.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: June 8, 2021
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Barbara A. Marcheschi
  • Publication number: 20210094872
    Abstract: A copper-doped glass formed by placing a target glass in a container, surrounding the target glass with a powder mixture comprised of SiO2 powder and Cu2S powder, wherein the SiO2 powder and the Cu2S powder are mixed according to the formula (SiO2)(1-x)(Cu2S)x, where 0.01<x<0.1, and heated to a temperature of between 800° C. and 1150° C. for a duration of between 1 and 10 hours.
    Type: Application
    Filed: December 10, 2020
    Publication date: April 1, 2021
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Barbara A. Marcheschi
  • Publication number: 20200355696
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Application
    Filed: June 8, 2020
    Publication date: November 12, 2020
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Patent number: 10780185
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: September 22, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson, Nashaat Rasheed, Parag V. Chitnis, John R. Cressman
  • Patent number: 10705092
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: July 7, 2020
    Assignee: The Government of the United States of Americam as Represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Patent number: 10247848
    Abstract: A 3Helium gas counter comprising a container, a gas tube within the container, and a mixture of 3Helium and Xenon or a mixture of 3Helium and Krypton. A method of making a 3Helium gas counter comprising providing a container, placing a gas tube within the container, and depositing a mixture of 3Helium and Xenon or a mixture of 3Helium and Krypton into the gas tube.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: April 2, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Alan L. Justus
  • Publication number: 20190039948
    Abstract: A method of making a copper-doped glass comprising placing a target glass in a container, placing a target glass in a container, surrounding the target glass with a powder mixture comprised of fused silica (SiO2) powder and copper sulfide (Cu2S) powder, such that both the target glass and the surrounding powder are contained in the container, and heating the container and the target glass and the surrounding powder mixture to a temperature of between 800° C. and 1150° C.
    Type: Application
    Filed: October 10, 2018
    Publication date: February 7, 2019
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Barbara A. Marcheschi
  • Publication number: 20180326097
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 15, 2018
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson, Nashaat Rasheed, Parag V. Chitnis, John R. Cressman
  • Patent number: 10125048
    Abstract: A copper dopant delivery powder comprising a fused silica powder and a Cu2S powder. A method of making the copper dopant delivery powder. A method of making a copper-doped glass comprising placing a target glass in a container, packing a composite SiO.CuS dopant powder around the target glass and heating the container and SiO.CuS dopant powder to a temperature of between 800° C. and 1150° C. A copper-doped glass comprising a glass comprising copper-doping wherein the copper-doped glass was formed by covering the glass with a fused silica powder and a Cu2S powder, wherein the fused silica powder and the Cu2S powder are mixed in varying ratios of Cu2S to silica represented by the formula (SiO2)(1-x)(Cu2S)x and heating to a temperature of between 800° C. and 1150° C.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: November 13, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Barbara A. Marcheschi
  • Publication number: 20180217153
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 2, 2018
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson
  • Publication number: 20180045848
    Abstract: A 3Helium gas counter comprising a container, a gas tube within the container, and a mixture of 3Helium and Xenon or a mixture of 3Helium and Krypton. A method of making a 3Helium gas counter comprising providing a container, placing a gas tube within the container, and depositing a mixture of 3Helium and Xenon or a mixture of 3Helium and Krypton into the gas tube.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 15, 2018
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Alan L. Justus
  • Patent number: 9880149
    Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: January 30, 2018
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Bertalan K. Andrasfalvy, Kimihiro Susumu, James B. Delehanty, Alan L. Huston, John J. Macklin, Mladen Barbic
  • Patent number: 9778392
    Abstract: A 3Helium gas counter comprising polyethylene slabs, a rectangular gas tube within the polyethylene slabs, and a mixture of 3Helium and Xenon. A 3Helium gas counter comprising polyethylene slabs, a rectangular gas tube within the polyethylene slabs, and a mixture of 3Helium and Krypton. A method of making a 3Helium gas counter comprising providing polyethylene slabs, placing a rectangular gas tube within the polyethylene slabs, and depositing a mixture of 3Helium and Xenon into the rectangular gas tube.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: October 3, 2017
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Alan L. Justus
  • Patent number: 9752986
    Abstract: Described herein is a time-gated, two-step FRET relay effective to provide temporal transference of a prompt FRET pathway, or provide spectro-temporal encoding analytical signals and other information. A FRET relay assembly includes a long lifetime FRET donor (for example, a lanthanide complex), a semiconductor quantum dot (QD) configured as an intermediate acceptor/donor in FRET, and a fluorescent dye configured as a terminal FRET acceptor, wherein the long lifetime FRET donor has an excited state lifetime of at least one microsecond and the QD and fluorescent dye each have excited state lifetimes of less than 100 nanoseconds.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: September 5, 2017
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: W. Russ Algar, Niko Hildebrandt, Alan L. Huston, Igor L. Medintz
  • Publication number: 20170240457
    Abstract: A copper dopant delivery powder comprising a fused silica powder and a Cu2S powder. A method of making the copper dopant delivery powder. A method of making a copper-doped glass comprising placing a target glass in a container, packing a composite SiO.CuS dopant powder around the target glass and heating the container and SiO.CuS dopant powder to a temperature of between 800° C. and 1150° C. A copper-doped glass comprising a glass comprising copper-doping wherein the copper-doped glass was formed by covering the glass with a fused silica powder and a Cu2S powder, wherein the fused silica powder and the Cu2S powder are mixed in varying ratios of Cu2S to silica represented by the formula (SiO2)(1-x)(Cu2S)x and heating to a temperature of between 800° C. and 1150° C.
    Type: Application
    Filed: February 14, 2017
    Publication date: August 24, 2017
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Barbara A. Marcheschi
  • Patent number: 9720112
    Abstract: A device having: a scintillator material, an optically transparent element containing a glass or polymer and gadolinium oxide, and one or more photomultiplier tubes adjacent to the scintillator material. The optically transparent element is surrounded by the scintillator material.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: August 1, 2017
    Assignee: The Government of the United States of America as represented by the Secretary of the Navy
    Inventors: Alan L. Huston, Brian L. Justus, Alan L. Justus
  • Publication number: 20160216399
    Abstract: A 3Helium gas counter comprising polyethylene slabs, a rectangular gas tube within the polyethylene slabs, and a mixture of 3Helium and Xenon. A 3Helium gas counter comprising polyethylene slabs, a rectangular gas tube within the polyethylene slabs, and a mixture of 3Helium and Krypton. A method of making a 3Helium gas counter comprising providing polyethylene slabs, placing a rectangular gas tube within the polyethylene slabs, and depositing a mixture of 3Helium and Xenon into the rectangular gas tube.
    Type: Application
    Filed: January 8, 2016
    Publication date: July 28, 2016
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Brian L. Justus, Alan L. Huston, Alan L. Justus
  • Publication number: 20160091619
    Abstract: A device having: a scintillator material, an optically transparent element containing a glass or polymer and gadolinium oxide, and one or more photomultiplier tubes adjacent to the scintillator material. The optically transparent element is surrounded by the scintillator material.
    Type: Application
    Filed: December 4, 2015
    Publication date: March 31, 2016
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Alan L. Huston, Brian L. Justus, Alan L. Justus