Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).

Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).

Abstract: The present invention provides a flow cell that can be used to improve the linear detection range of a radio-detector. The flow cell of the present invention is simple and cost-effective to set up and provides technical advantages over methods known in the prior art, as set out in more detail hereunder. The present invention also provides a method to determine the RCP of a radioactive composition making use of said flow cell, and a HPLC system comprising said flow cell.

Abstract: The present invention provides a flow cell that can be used to improve the linear detection range of a radio-detector. The flow cell of the present invention is simple and cost-effective to set up and provides technical advantages over methods known in the prior art, as set out in more detail hereunder. The present invention also provides a method to determine the RCP of a radioactive composition making use of said flow cell, and a HPLC system comprising said flow cell.

Abstract: Aluminum, boron and silicon were identified as potential leachables from borosilicate glassware and a silica based QMA during handling of aqueous 18F. The addition of only 0.4 ppm aluminum as AlCl3 in the eluent vial resulted in a strong reduction in the labeling yield of a model [18F]fluoride SN2 reaction (from 80 to 40% incorporation). The addition of boron as KBO2 and silicon as NaSiO3 did not result in any significant decrease in labeling yield. Interestingly, there was an interaction effect between AlCl3 and KBO2 in which the negative effect from AlCl3 on labeling yield was counteracted by KBO2. The present invention demonstrates that aluminum and boron from borosilicate glassware have a strong influence on the labeling yield in nucleophilic SN2 reactions with n.c.a [18F]fluoride.

Abstract: The present invention claims a method for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. The present invention also provides for an apparatus for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. Kit claims for formation of [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species are also provided.

Abstract: The present invention relates to a method of electrochemically desorbing or adsorbing a cryptate [18F] fluoride complex using a substituent substituted cryptand A. The present invention also relates to an apparatus and a kit for performing this method. A: which can be used for nucleophilic radiofluorination.

Abstract: A method of electrochemically separating [18F] fluoride from [18O] water comprising a device that encompasses two or more electrodes, wherein said device allows entry and exit of solutions within a chamber wherein an electric field is applied over said electrodes whereby the electrodes consist of an electrode material wherein the electrode material inhibits electrochemical reactions of precursors from reacting thus forming nucleophilic [18F] fluoride solutions. The present invention also provides for an apparatus for separating [18F] fluoride from [18O] water.

Abstract: The present invention claims a method for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. The present invention also provides for an apparatus for forming [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species. Kit claims for formation of [18F] fluoride complexes suitable for performing radio-labelling reactions to generate [18F] fluorinated species are also provided.

Abstract: The present invention relates to a method of electrochemically desorbing or adsorbing a cryptate [18F] fluoride complex using a substituent substituted cryptand A. The present invention also relates to an apparatus and a kit for performing this method.