Abstract: An air filtration and purification system, particularly adapted for treating contaminated air within a preselected zone of a building interior space, includes a filter and purifier unit comprising first and second stage particle filters, an odor neutralizer comprising an ozone generator, an activated carbon adsorbent media for extracting gaseous compositions exposed to the ozone injected into the airflow stream and an ultrahigh efficiency final stage particle filter. All filter units and the ozone generator are disposed in a cabinet together with one or more air propulsion fans interposed between the second stage particle filter and the adsorbent media. The system is particularly configured for removing air containing tobacco smoke and other contaminants from smoking areas of restaurants and other places of business and may be configured to return purified and odorized air through ceiling ducts to form an air curtain defining the zone.