Patents by Inventor Alberto Gandini

Alberto Gandini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200110081
    Abstract: The present invention provides microfluidic pScreen™ devices for quantifying the concentration of DNA fragments in a liquid sample by using magnetic-responsive silica micro-beads and nonmagnetic-responsive silica micro-beads. The devices of the present invention allow for rapid, simple and inexpensive quantification of DNA fragment concentration in a sample. The devices do not require complex instrumentation and can be performed in less than three minutes. Moreover, they are compatible with complex samples including, without limitation, unpurified PCR amplification products, and thus can be expected to seamlessly integrate into various common molecular biology techniques and workflows.
    Type: Application
    Filed: December 2, 2019
    Publication date: April 9, 2020
    Applicant: Carnegie Mellon University
    Inventors: Alberto Gandini, James F. Antaki, Byron Wang Chuan, Joie N. Marhefka, Juha-Pekka Mattila, Eliseo Salas
  • Patent number: 10495634
    Abstract: The present invention provides a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: December 3, 2019
    Assignee: Carnegie Mellon University
    Inventors: Alberto Gandini, James F. Antaki, Byron Wang Chuan, Joie N. Marhefka
  • Publication number: 20170370921
    Abstract: The present invention provides a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Application
    Filed: August 2, 2017
    Publication date: December 28, 2017
    Applicant: Carnegie Mellon University
    Inventors: Alberto Gandini, James F. Antaki, Byron Wang Chuan, Joie N. Marhefka
  • Patent number: 9753029
    Abstract: The present invention provides a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: September 5, 2017
    Assignee: Carnegie Mellon University
    Inventors: Alberto Gandini, James F. Antaki, Byron Wang Chuan, Joie N. Marhefka
  • Publication number: 20140120633
    Abstract: The present invention provides a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 1, 2014
    Applicant: CARNEGIE MELLON UNIVERSITY
    Inventors: Alberto Gandini, James F. Antaki, Byron Wang Chuan, Joie N. Marhefka
  • Patent number: 8623596
    Abstract: The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: January 7, 2014
    Assignee: Carnegie Mellon University
    Inventors: Alberto Gandini, James F. Antaki
  • Patent number: 8556843
    Abstract: Methods for treating malaria are provided, the treatment comprising the step of removing malaria-infected red blood cells from the patient's blood. Blood is drawn from the patient's circulatory system and circulated through a blood purification device that selectively eliminates the infected red blood cells from all other blood's components and replaces the cleansed blood back into the patient's circulatory system. A blood purification device, which is useful to perform the therapeutic methods of the invention, is also provided. The device leverages the magnetic properties of the hemozoin contained within the infected red blood cells and comprises one or more separation chambers (4) though which blood flows through a high-gradient magnetic field generated by an array of wires (5) separated from the chambers and not in contact with the patient blood.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: October 15, 2013
    Assignee: AccelDx
    Inventors: Alberto Gandini, Roy Weinstein, Ravi-persad Sawh, Drew Parks
  • Patent number: 8445192
    Abstract: The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: May 21, 2013
    Assignee: Carnegie Mellon University
    Inventors: Alberto Gandini, James F. Antaki
  • Publication number: 20130078615
    Abstract: The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 28, 2013
    Inventors: Alberto Gandini, James F. Antaki
  • Publication number: 20130078620
    Abstract: The present invention provides a method and device for detecting and quantifying the concentration of magnetic-responsive micro-beads dispersed in a liquid sample. Also provided is a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a sample medium by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.
    Type: Application
    Filed: November 26, 2012
    Publication date: March 28, 2013
    Inventors: Alberto Gandini, James F. Antaki
  • Publication number: 20100331753
    Abstract: Methods for treating malaria are provided, the treatment comprising the step of removing malaria-infected red blood cells from the patient s blood. Blood is drawn from the patient s circulatory system and circulated through a blood purification device that selectively eliminates the infected red blood cells from all other blood s components and replaces the cleansed blood back into the patient s circulatory system. A blood purification device, which is useful to perform the therapeutic methods of the invention, is also provided. The device leverages the magnetic properties of the hemozoin contained within the infected red blood cells and comprises one or more separation chambers (4) though which blood flows through a high-gradient magnetic field generated by an array of wires (5) separated from the chambers and not in contact with the patient blood.
    Type: Application
    Filed: February 2, 2009
    Publication date: December 30, 2010
    Inventor: Alberto Gandini
  • Patent number: 5501920
    Abstract: A solid polymeric electrolytic membrane comprising a solution of an ion compound in a cross-linked polyether including a liquid plasticizer obtained by:a) copolymerizing a vinyl ether of the formula:R--(O--CH.sub.2 --CH.sub.2 --).sub.n --O--CH=CH.sub.2 (I)with an allyl vinyl ether of the formula:CH.sub.2 =CH--CH.sub.2 --(O--CH.sub.2 --CH.sub.2 --).sub.m --O--CH=CH.sub.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: March 26, 1996
    Assignee: Eniricerche S.p.A.
    Inventors: Maria Andrei, Arnaldo Roggero, Massimo Soprani, Alberto Gandini
  • Patent number: 5354507
    Abstract: Compounds of general formula ##STR1## wherein: R is a linear or branched C.sub.1 -C.sub.20 alkyl radical, m is either 0 or 1; n has a value of from 1 to 10, are corrosion inhibitors, suitable for inhibiting the general corrosion and the stress brittlening caused by hydrogen sulfide (SSC), in an acidic environment, in the presence, or absence of carbon dioxide, of medium-and high-strength manganese steels and low-alloy steels, commonly used in petrochemical facilities and in bore drilling, transport and processing systems for natural gas or petroleum.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: October 11, 1994
    Assignee: Eniricerche S.p.A
    Inventors: Viviana De Malde, Luigi Rivola, Arnaldo Roggero, Alberto Gandini
  • Patent number: 5171794
    Abstract: An amorphous modified poly(2,6-dimethyl-p-oxyphenylene) (PPO) is described with a glass transition temperature (Tg) within the range of 170.degree.-220.degree. C., of which the macromolecules contain units having trialkylsilyl groups bonded to the nucleus and/or to the methyl: ##STR1## together with units having hydroxyethyl groups bonded to the nucleus and/or to the methyl: ##STR2## This modified PPO is prepared by metalating PPO with a metalating agent and reacting the formed metalated PPO with a trialkylsilyl halide and with ehtylene oxide in succession.The use of the thus modified PPO for the preparation of flat, including asymmetric, membranes useful in gas mixture separation processes is described.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: December 15, 1992
    Assignees: Eniricerche S.p.A., Snam S.p.A., Agip Petroli S.p.A.
    Inventors: Amalia Assogna, Alberto Gandini, Arnaldo Roggero, Raffaello Sisto, Alessandro Stopponi, Claudio Valentini
  • Patent number: 5169416
    Abstract: A process for preparing a modified, amorphous poly-(2,6-dimethyl-p-oxyphenylene) (PPO) comprises:(a) metalating PPO with a metalating agent, and(b) functionalizing such a metalated PPO by reacting the PPO with a trialkylsilyl halide and/or ethylene oxide; and is characterized in that the reaction of metalation is carried out in an inert liquid vehicle which contains PPO in an at least partially suspended solid form, by operating under metalating conditions of gradually adding metalating agent to such a suspension, either continuously or as discrete portions. Depending on the functionalizing agents used, and on the sequence of addition thereof, the process makes it possible to obtain PPO polymers which are modified with trialkyl-silyl, hydroxyethylene and/or ethyleneoxytrialkyl-silyl functional groups. The modified PPO polymers are particularly suitable for preparing flat membranes, including asymmetrical membranes, for the separation of gas mixtures.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: December 8, 1992
    Assignees: Snam S.p.A., Eniricerche S.p.A., Agip Petroli S.p.A.
    Inventors: Ugo Pedretti, Alberto Gandini, Arnaldo Roggero, Raffaello Sisto, Claudio Valentini, Amalia Assogna, Alessandro Stopponi
  • Patent number: 5019631
    Abstract: A modified poly(2,6-dimethyl-p-oxyphenylene) with a glass transition temperature in the range of 180.degree.-220.degree. C. is described in which on the average between 10 and 60% of the macromolecules carry:a) an ##STR1## unit; or b) an ##STR2## unit. Said modified poly(2,6-dimethyl-p-oxyphenylene) is useful as a material in the preparation of flat membranes, in particular asymmetric membrane, for gas separation.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: May 28, 1991
    Assignee: Eniricerche S.p.A.
    Inventors: Otello Farias, Alberto Gandini, Raffaella Monga, Arnaldo Roggero, Raffaello Sisto, Claudio Valentini
  • Patent number: 4754005
    Abstract: Coupling agents of general formula ##STR1## and their use in a method for the termination of living polymers obtained by the anionic polymerization of dienic and/or vinylaromatic monomers.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: June 28, 1988
    Assignee: Eniricerche S.p.A.
    Inventors: Arnaldo Roggero, Alberto Gandini
  • Patent number: 4735994
    Abstract: Coupling agents of general formula ##STR1## and their use in a method for the termination of living polymers obtained by the anionic polymerization of dienic and/or vinylaromatic monomers.
    Type: Grant
    Filed: June 24, 1986
    Date of Patent: April 5, 1988
    Assignee: Eniricerche S.p.A.
    Inventors: Arnaldo Roggero, Alberto Gandini
  • Patent number: 4734461
    Abstract: Coupling agents of general formula ##STR1## and their use in a method for the termination of living polymers obtained by the anionic polymerization of dienic and/or vinylaromatic monomers.
    Type: Grant
    Filed: June 20, 1986
    Date of Patent: March 29, 1988
    Assignee: Eniricerche S.p.A.
    Inventors: Arnaldo Roggero, Alberto Gandini
  • Patent number: 4701498
    Abstract: Coupling agents of general formula ##STR1## and their use in a method for the termination of living polymers obtained by the anionic polymerization of dienic and/or vinylaromatic monomers.
    Type: Grant
    Filed: June 24, 1986
    Date of Patent: October 20, 1987
    Assignee: Eniricerche S.p.A.
    Inventors: Arnaldo Roggero, Alberto Gandini