Patents by Inventor Aldo Balsamo

Aldo Balsamo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors
    Patent number: 8329751
    Abstract: The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, R4, R5, n and m have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: December 11, 2012
    Assignee: Bracco Imaging S.p.A.
    Inventors: Aldo Balsamo, Armando Rossello, Elisa Nuti, Elisabetta Orlandini, Tiziano Tuccinardi
  • Thioaryl substituted inhibitors of zinc proteases and their use
    Patent number: 8093386
    Abstract: There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc metalloproteinases.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: January 10, 2012
    Assignee: Bracco Imaging S.p.A
    Inventors: Armando Rossello, Elisabetta Orlandini, Aldo Balsamo, Laura Panelli, Elisa Nuti
  • Compounds Having Aryl-Sulphonamidic Structure Useful As Metalloproteases Inhibitors
    Publication number: 20100087505
    Abstract: The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, R4, R5, n and m have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.
    Type: Application
    Filed: March 14, 2008
    Publication date: April 8, 2010
    Applicant: Bracco Imaging S.p.A.
    Inventors: Aldo Balsamo, Armando Rossello, Elisa Nuti, Elisabetta Orlandini, Tziano Tuccinardi
  • THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE
    Publication number: 20090239829
    Abstract: There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc metalloproteinases.
    Type: Application
    Filed: July 25, 2007
    Publication date: September 24, 2009
    Applicant: BRACCO IMAGING SPA
    Inventors: Armando Rossello, Elisabetta Orlandini, Aldo Balsamo, Laura Panelli, Elisa Nuti
  • 1-PHENYLALCOXY-2-BETA-PHENYLETHYL DERIVATIVES AS P-GLYCOPROTEIN (P-GP) INHIBITORS USEFUL IN DRUG RESISTANCE EVENTS
    Publication number: 20090093493
    Abstract: The invention relates to a new class of compounds, which are 1-phenylalcoxy-2-?-phenylethyl derivatives, as P-glycoprotein (P-GP) inhibitors. These compounds are useful in drug resistance events. They have been shown able to inhibit in a dose-dependent manner Glycoprotein-P (P-gp) activity in cell lines in which the expression of said glycoprotein is very high, like Caco-2 (human colon cancer) cells and MCF7/Adr (adriamycin-resistant human breast carcinoma) cells. The invention also relates to methods of production and the utilization of such compounds as medicaments useful in the treatment of states linked to the difficulty for some drugs to cross the blood-brain barrier (BBB) and generally within the context of the problems of drug resistance induced by chemotherapy agents.
    Type: Application
    Filed: October 9, 2007
    Publication date: April 9, 2009
    Inventors: Francesco Berardi, Nicola Antonio Colabufo, Roberto Perrone, Aldo Balsamo, Simona Rapposelli, Maria Digiacomo
  • Ceramide analogs, process for their preparation and their use as antitumor agents
    Patent number: 7214794
    Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: May 8, 2007
    Assignee: Bracco S.p.A.
    Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
  • Ceramide analogs, process for their preparation and their use as antitumor agents
    Patent number: 6956109
    Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 18, 2005
    Assignee: Bracco S.p.A.
    Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
  • Ceramide analogs, process for their preparation and their use as antitumor agents
    Publication number: 20050020533
    Abstract: The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors.
    Type: Application
    Filed: August 17, 2004
    Publication date: January 27, 2005
    Inventors: Bruno Macchia, Aldo Balsamo, Marco Macchia, Mario Del Tacca, Romano Danesi
  • Geranylgeranyl-derivatives, process for the preparation thereof and related pharmaceutical compositions
    Patent number: 6242433
    Abstract: The present invention relates to novel geranylgeranyl derivatives and the pharmaceutically acceptable salts thereof having antiproliferative activity in eukaryotic cells with respect to the inhibition of protein geranygeranylation. The invention also relates to the pharmaceutical compositions containing the novel derivatives and to the process of preparation thereof.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: June 5, 2001
    Assignee: Laboratori Baldacci SpA
    Inventors: Aldo Balsamo, Bruno Macchia, Marco Macchia, Massimo Baldacci, Romano Danesi, Mario Del Tacca