Patents by Inventor Aldo Banfi

Aldo Banfi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130345283
    Abstract: A process for the preparation of Rotigotine (1) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid-sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7, 8-tetrahydro-6-(S)-N-propylamino-1-methoxy-naphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed.
    Type: Application
    Filed: July 23, 2013
    Publication date: December 26, 2013
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Aldo Banfi, Gianluca Belogi, Claudio Fuganti, Roberta Pizzocaro
  • Publication number: 20130317255
    Abstract: A process for the preparation of Rotigotine (1) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid-sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7,8-tetrahydro-6-(S)—N-propylamino-1-methoxy-naphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed.
    Type: Application
    Filed: July 23, 2013
    Publication date: November 28, 2013
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Aldo Banfi, Gianluca Belogi, Claudio Fuganti, Roberta Pizzocaro
  • Patent number: 8519160
    Abstract: A process for the preparation of Rotigotine (I) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid-sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate (II). The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7,8-tetrahydro-6-(S)-N-propylamino-1-methoxynaphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: August 27, 2013
    Assignee: Fidia Farmaceutici S.p.A.
    Inventors: Aldo Banfi, Gialunca Belogi, Claudio Fuganti, Roberta Pizzocaro
  • Publication number: 20110230541
    Abstract: A process for the preparation of Rotigotine (I) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid-sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate (II) The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7,8-tetrahydro-6-(S)-N-propylamino-1-methoxy-naphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed.
    Type: Application
    Filed: September 24, 2009
    Publication date: September 22, 2011
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Aldo Banfi, Gianluca Belogi, Claudio Fuganti, Roberta Pizzocaro
  • Patent number: 7858779
    Abstract: Process for preparing oxcarbazepine according to the steps of chlorocarbonylating (a), ammonolysis (b), and deprotecting (c). The invention is characterized by the use of triphosgene as chlorocarbonylating agent in step a).
    Type: Grant
    Filed: February 21, 2005
    Date of Patent: December 28, 2010
    Assignee: Archimica S.r.l.
    Inventors: Aldo Banfi, Deborah Bollini, Maurizio Serra, Gianluca Di Lernia
  • Publication number: 20100226944
    Abstract: The present invention relates to a process for the preparation of controlled-release solid oral pharmaceutical formulations of oxcarbazepine, and the pharmaceutical formulations obtainable by said process.
    Type: Application
    Filed: July 23, 2008
    Publication date: September 9, 2010
    Applicant: ARCHIMICA S.R.L.
    Inventors: Giovanni Sanso', Aldo Banfi, Giorgio Bertolini, Claudio Silva
  • Patent number: 7285660
    Abstract: A process for the preparation of L-ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: October 23, 2007
    Assignee: Archimica S.r.l.
    Inventors: Aldo Banfi, Bruno Dall'Oro, Marco Frigerio, Alfredo Mancini
  • Patent number: 7285659
    Abstract: A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises: a) the reaction of a triazole of the formula ?with a protected ribofuranose of the formula b) the removal of the Pg groups and, optionally, the conversion into a carboxyamide group of the R2 group of the compound obtained of the formula ?DD/mac—01.07.02.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: October 23, 2007
    Assignee: Archimica S.r.l.
    Inventors: Aldo Banfi, Bruno Dall'Oro, Marco Frigerio, Alfredo Mancini
  • Publication number: 20070149507
    Abstract: Process for preparing oxcarbazepine according to the steps of chlorocarbonylating (a), ammonolysis (b), and deprotecting (c). The invention is characterized by the use of triphosgene as chlorocarbonylating agent in step a).
    Type: Application
    Filed: February 21, 2005
    Publication date: June 28, 2007
    Inventors: Aldo Banfi, Deborah Bollini, Maurizio Serra
  • Patent number: 7091382
    Abstract: A process is disclosed for manufacturing N-methyl-N-phenylaminoacrolein of formula (I) which comprises reacting N-methylformanilide and an alkyl vinyl ether of formula (III) wherein R is a C3–C4 alkyl, said process being characterized in that the reaction between N-methylformanilide and said alkyl vinyl ether of formula (III) is carried out in the presence of phosgene, diphosgene or triphosgene in a solvent selected from dioxane, acetonitrile and/or chlorobenzene.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: August 15, 2006
    Assignee: Clariant Life Science Molecules (Italia) S.p.A.
    Inventors: Aldo Banfi, Alfredo Mancini
  • Publication number: 20040229958
    Abstract: A process is disclosed for manufacturing N-methyl-N-phenylaminoacrolein of formula (I) 1
    Type: Application
    Filed: May 7, 2004
    Publication date: November 18, 2004
    Applicant: Clariant Life Science Molecules (Italia) S.p.A.
    Inventors: Aldo Banfi, Alfredo Mancini
  • Publication number: 20040192904
    Abstract: A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 30, 2004
    Inventors: Aldo Banfi, Bruno Dall'Oro, Marco Frigerio, Alfredo Mancini
  • Publication number: 20040176587
    Abstract: A process for the preparation of L-ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid and of a solvent. Said process comprises: a) the reaction of a triazole of formula (I) with a protected L-ribofuranose of formula (II)b) the removal of the Pg groups and, optionally, the conversion into a carboxyamide group of the R2 group of the compound obtained of formula (III) to give L-ribavirin.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 9, 2004
    Inventors: Aldo Banfi, Bruno Dall'Oro, Marco Frigerio, Alfredo Mancini
  • Patent number: 6433177
    Abstract: It is here described a new process for the synthesis of (S)-N-tertbutyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide wherein the N-carboxy anhydride of formula is treated with tert-butylamine in an organic inert solvent, preferably toluene, at a temperature of between −80 and −30° C.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: August 13, 2002
    Assignee: Clariant LSM Italia S.P.A.
    Inventors: Pietro Bellani, Aldo Banfi
  • Patent number: 5589490
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: December 31, 1996
    Assignee: Italfarmaco S.p.A.
    Inventors: Alberto Sala, Aldo Banfi, Francesca Benedini, Roberta Cereda
  • Patent number: 5366992
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: November 22, 1994
    Assignee: Italfarmaco S.p.A.
    Inventors: Alberto Sala, Aldo Banfi, Francesca Benedini, Roberta Cereda