Patents by Inventor Alexander Groisman
Alexander Groisman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240060961Abstract: Provided are methods and compositions for cell-based drug screening with high-density arrays of conical microwells and slow-drug-release beads.Type: ApplicationFiled: October 30, 2023Publication date: February 22, 2024Inventors: Eugene Tkachenko, Natalia Tkachenko, Edgar Gutierrez, Alexander Groisman
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Publication number: 20190137481Abstract: Provided are methods and compositions for cell-based drug screening with high-density arrays of conical microwells and slow-drug-release beads.Type: ApplicationFiled: November 1, 2018Publication date: May 9, 2019Inventors: Eugene Tkachenko, Natalia Tkachenko, Edgar Gutierrez, Alexander Groisman
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Patent number: 9039171Abstract: A contact lens assembly includes a proximal layer formed from a gas-permeable material, a distal layer with an optical element, an air cavity disposed between the proximal layer and the distal layer, wherein oxygen concentration across the air cavity is substantially uniform, and an gas transport region surrounding the air cavity for communicating gas between the air cavity and atmosphere. The contact lens assembly may further include a plurality of fins disposed within the air cavity where the plurality of fins has openings therethrough. One or both of the upper and lower surfaces of the air cavity may have an anti-reflection coating formed thereon.Type: GrantFiled: April 24, 2013Date of Patent: May 26, 2015Assignee: The Regents of the University of CaliforniaInventor: Alexander Groisman
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Publication number: 20130337486Abstract: The ability to form and maintain gradients is essential for the study of response of cells to various stimuli. The invention includes devices and methods for the high-throughput, reproducible formation of gradients for the study of living cells. The invention includes microfluidics device with a lest chamber having a depth flanked by flow-through channels having a deeper depth. Flow of two different fluids through the flow-through channels results in the creation of a gradient by diffusion across the test chamber having essentially no flow.Type: ApplicationFiled: May 24, 2013Publication date: December 19, 2013Applicants: UCSD TECH TRANSFER OFFICE, THE JOHNS HOPKINS UNIVERSITYInventors: Andre Levchenko, Alexander Groisman, Saurabh Paliwal
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Publication number: 20130308092Abstract: A contact lens assembly includes a proximal layer formed from a gas-permeable material, a distal layer with an optical element, an air cavity disposed between the proximal layer and the distal layer, wherein oxygen concentration across the air cavity is substantially uniform, and an gas transport region surrounding the air cavity for communicating gas between the air cavity and atmosphere. The contact lens assembly may further include a plurality of fins disposed within the air cavity where the plurality of fins has openings therethrough. One or both of the upper and lower surfaces of the air cavity may have an anti-reflection coating formed thereon.Type: ApplicationFiled: April 24, 2013Publication date: November 21, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Alexander Groisman
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Patent number: 8449837Abstract: The ability to form and maintain gradients is essential for the study of response of cells to various stimuli. The invention includes devices and methods for the high-throughput, reproducible formation of gradients for the study of living cells. The invention includes microfluidics device with a test chamber having a depth flanked by flow-through channels having a deeper depth. Flow of two different fluids through the flow-through channels results in the creation of a gradient by diffusion across the test chamber having essentially no flow.Type: GrantFiled: October 11, 2006Date of Patent: May 28, 2013Assignees: The Johns Hopkins University, UCSD Tech Transfer OfficeInventors: Andre Levchenko, Alexander Groisman, Saurabh Paliwal
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Patent number: 8372358Abstract: In a microfluidic system, a magnetic clamp for sealing a flexible microchannel chip includes a base formed from a magnetically-attractable material. The base supports a window for viewing the face of the microfluidic chip. A ring with magnets uniformly distributed around it is disposed over the base. A transparent disk attached to the top of the ring has an inlet and an outlet for introducing and removing a fluid medium into a cavity defined the disk, the window, the center opening of the ring and the base. An elastomer cushion is attached to the inner surface of the disk. The magnetic force between the base and the magnets on the ring compresses the cushion against the microfluidic chip so that the microchannels are sealed against the window with a uniform and reproducible pressure.Type: GrantFiled: August 23, 2010Date of Patent: February 12, 2013Assignee: The Regents of the University of CaliforniaInventors: Alexander Groisman, Edgar Gutierrez, Eugene Tkachenko, Mark H. Ginsberg
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Publication number: 20110044865Abstract: In a microfluidic system, a magnetic clamp for sealing a flexible microchannel chip includes a base formed from a magnetically-attractable material. The base supports a window for viewing the face of the microfluidic chip. A ring with magnets uniformly distributed around it is disposed over the base. A transparent disk attached to the top of the ring has an inlet and an outlet for introducing and removing a fluid medium into a cavity defined the disk, the window, the center opening of the ring and the base. An elastomer cushion is attached to the inner surface of the disk. The magnetic force between the base and the magnets on the ring compresses the cushion against the microfluidic chip so that the microchannels are sealed against the window with a uniform and reproducible pressure.Type: ApplicationFiled: August 23, 2010Publication date: February 24, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Alexander Groisman, Edgar Gutierrez, Eugene Tkachenko, Mark H. Ginsberg
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Patent number: 7892836Abstract: The capillary gun for delivery of ballistic particles to a target includes an inner capillary tube disposed concentrically within an outer capillary tube with the input end of the inner tube connected to a channel through which a continuous flow of high speed helium gas carrying ballistic particles is introduced. The outer capillary tube, which is connected to a vacuum source, has an outlet end that extends slightly beyond the end of the inner tube. A cap placed over the output end of the outer tube has an opening at its center through which the particles exit the device. The vacuum source applies continuous suction to the space between the outer tube and the inner tube, drawing the gas from the output end of the inner tube while the inertia of the accelerated particles causes them to continue in the axial direction through the exit opening for delivery to the target. Multiple particle injectors provide for the concurrent injection of different materials without disruption of the gas flow.Type: GrantFiled: February 13, 2006Date of Patent: February 22, 2011Assignee: The Regents of the University of CaliforniaInventors: Alexander Groisman, Claire Simonnet, Dmitry Rinberg
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Publication number: 20100035292Abstract: The ability to form and maintain gradients is essential for the study of response of cells to various stimuli. The invention includes devices and methods for the high-throughput, reproducible formation of gradients for the study of living cells. The invention includes microfluidics device with a test chamber having a depth flanked by flow-through channels having a deeper depth. Flow of two different fluids through the flow-through channels results in the creation of a gradient by diffusion across the test chamber having essentially no flow.Type: ApplicationFiled: October 11, 2006Publication date: February 11, 2010Applicant: The Johns Hopkins UniversityInventors: Andre Levhenko, Alexander Groisman, Saurabh Paliwal
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Publication number: 20080206870Abstract: The capillary gun for delivery of ballistic particles to a target includes an inner capillary tube disposed concentrically within an outer capillary tube with the input end of the inner tube connected to a channel through which a continuous flow of high speed helium gas carrying ballistic particles is introduced. The outer capillary tube, which is connected to a vacuum source, has an outlet end that extends slightly beyond the end of the inner tube. A cap placed over the output end of the outer tube has an opening at its center through which the particles exit the device. The vacuum source applies continuous suction to the space between the outer tube and the inner tube, drawing the gas from the output end of the inner tube while the inertia of the accelerated particles causes them to continue in the axial direction through the exit opening for delivery to the target. Multiple particle injectors provide for the concurrent injection of different materials without disruption of the gas flow.Type: ApplicationFiled: February 13, 2006Publication date: August 28, 2008Inventors: Alexander Groisman, Claire Simonnet, Dmitry Rinberg
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Patent number: 6632014Abstract: A method and device for mixing a liquid with another substance are presented. The mixing is based on creation of a turbulent flow of the liquid, by providing curvilinear trajectories of the flow and providing a polymer material in the liquid flow.Type: GrantFiled: December 4, 2000Date of Patent: October 14, 2003Assignee: Yeda Research and Development Co., Ltd.Inventors: Victor Steinberg, Alexander Groisman
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Publication number: 20020093878Abstract: A method and device for mixing a liquid with another substance are presented. The mixing is based on creation of a turbulent flow of the liquid, by providing curvilinear trajectories of the flow and providing a polymer material in the liquid flow.Type: ApplicationFiled: December 4, 2000Publication date: July 18, 2002Applicant: Yeda Research and Development Co. Ltd.Inventors: Victor Steinberg, Alexander Groisman