Patents by Inventor Alexander J. ANNALA

Alexander J. ANNALA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10709745
    Abstract: In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: July 14, 2020
    Assignees: CITY OF HOPE, UNIVERSITY OF ALABAMA AT BIRMINGHAM, UNIVERSITY OF CHICAGO
    Inventors: Karen S. Aboody, Alexander J. Annala, David Curiel, Maciej Lesniak
  • Publication number: 20200038453
    Abstract: Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and an oncolytic virus or a combination of oncolytic virotherapy and immune modulation. The method entails administrating to a subject a pharmaceutical composition comprising a combination of NSCs and an oncolytic virus, and/or NSCs packaged with one or more immunomodulatory viruses expressing one or more immunity checkpoint inhibitors, including adaptive immunity checkpoint inhibitors and innate immunity checkpoint inhibitors. The immunity checkpoint inhibitors include shRNAs against the immunity checkpoint proteins. The cancer includes but is not limited to primary, recurrent, and metastatic brain cancer, breast cancer, head and neck cancer, bladder cancer, ovarian cancer, uterine cancer, prostate cancer, skin cancer, lung cancer, and colorectal cancer.
    Type: Application
    Filed: April 29, 2019
    Publication date: February 6, 2020
    Inventors: Alexander J. Annala, Karen Aboody, Jennifer Covello, Rachael Mooney
  • Publication number: 20190275093
    Abstract: In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.
    Type: Application
    Filed: March 21, 2019
    Publication date: September 12, 2019
    Inventors: Karen S. ABOODY, Alexander J. ANNALA, David CURIEL, Maciej LESNIAK
  • Patent number: 10238699
    Abstract: In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: March 26, 2019
    Assignees: CITY OF HOPE, UNIVERSITY OF CHICAGO, UNIVERSITY OF ALABAMA AT BIRMINGHAM
    Inventors: Karen S. Aboody, Alexander J. Annala, David Curiel, Maciej Lesniak
  • Publication number: 20160317591
    Abstract: In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.
    Type: Application
    Filed: September 11, 2015
    Publication date: November 3, 2016
    Inventors: Karen S. ABOODY, Alexander J. ANNALA, David CURIEL, Maciej LESNIAK