Abstract: A novel gRNA-ligand binding complex is provided. This complex may be used to bring Type V Cas proteins and additional effectors to DNA for base editing. The design of the systems allows for the production of efficient modular components that provide flexibility when editing DNA.

Abstract: Systems and methods for combatting shrinking forces within drying photopolymers of additive manufacturing processes are disclosed herein. According to at least some embodiments, layers of an additive manufacturing build are split into core components and shell components. Magnetically active additives within the photopolymer resin are then aligned in a first plane while the core section is cured, and a second plane while the outer shell section is cured. According to at least some embodiments, the first plane and the second plane are perpendicular.

Abstract: Systems and methods are provided for generating an interactive map for displaying and analyzing a compressive intellectual property landscape within a given field. Based on content analysis of relevant patents and patent applications, this prior art map provides a systematic review of vast quantities of data, thereby allowing the user to discern critical technology and product trends, prior art references, and the strategies of both leading and emerging competitors. Each patent represented on the map can be analyzed within the context of the prior art landscape to uncover novel features, strong claims, and business and technology trends. This comprehensive view can provide a foundation for creating effective corporate strategies in-tune with the realities of the intellectual property terrain.

Abstract: A sports training device that includes a pressure sensor mounted on the hand grip of a sports implement such as a tennis racket or a golf club. The device utilizes a piezoelectric force sensor to monitor the grip pressure in a circular sensing area located where the palm meets the index finger. The piezoelectric sensor varies its resistance inversely with the force applied and is connected to an operational amplifier that uses a variable resistor to deliver an output voltage proportional to the force applied. This voltage triggers a vibrating motor that alerts the user that an excessive pressure has been applied to the hand grip. The exact amount of pressure for each player and the sports equipment used will vary but can be adjusted to signal when the pressure is too great for the particular use.

Abstract: A training device that will train a player to throw the ball to the correct height and angle for a serve is provided. The device includes a pole that adjusts from about four feet to twelve feet in height to suit a player's need. The pole is supported by a base and includes an toss hoop at the top of the pole. A photo-sensor is provided at the toss hoop to record a valid toss when a ball is tossed upwardly through the hoop within a predetermined height range and descends through the hoop prior to the serve. A basket may be positioned at the base for retrieving the tossed practice balls. The base legs and toss hoop fold away for easy storage and transport.

Abstract: A sports training device including a pressure sensor mounted on the grip of a tennis racket or golf club is provided. The device includes a peizo-electric force sensor to monitor the grip pressure in a circular sensing area located under where palm meets the index finger. The peizo-electric sensor varies its resistance inversely with force applied is connected to an op-amp that uses a variable resistor to deliver an output voltage proportional to the force applied. This voltage triggers a vibrating motor to spin, thus alerting the user that he or she has squeezed too hard. This variable pressure sensor is connected to an alarm that will immediately notify the user when the grip is too tight. The exact amount of pressure for each player and the sports equipment used will vary widely, but can be adjusted to signal when the pressure is too great for the particular use.

Abstract: A training device that will train a player to throw the ball to the correct height and angle for a serve is provided. The device includes a pole that adjusts from about four feet to twelve feet in height to suit a player's need. The pole is supported by a base and includes an toss hoop at the top of the pole. A photo-sensor is provided at the toss hoop to record a valid toss when a ball is tossed upwardly through the hoop within a predetermined height range and descends through the hoop prior to the serve. A basket may be positioned at the base for retrieving the tossed practice balls. The base legs and toss hoop fold away for easy storage and transport.

Abstract: A training device that will train a player to throw the ball to the correct height and angle for a serve is provided. The device includes a pole that adjusts from about four feet to twelve feet in height to suit a player's need. The pole is supported by a base and includes an upper toss hoop at the top of the pole and a lower guide hoop at the bottom of the pole for receiving and locating the position of the tossed tennis ball. In one embodiment the lower guide hoop includes or is replaced by a basket for retrieving the tossed practice balls. The base legs and upper and lower hoops fold away for easy storage and transport.

Abstract: Methods and apparatuses for determining conductivity of a subterranean formation traversed by a well, particularly a cased well are provided. Variations in casing conductivity and/or electrode placement, arising from, e.g. thermal stress or expansion or corrosion, are compensated for. Compensation involves obtaining voltages developed in response to current flowing between relatively closely spaced current electrodes, and using these voltages to provide compensation for voltages developed in response to current flowing between more remotely positioned current electrodes. Modifications are described to permit conductivity measurements in partially cased or uncased wells, or wells being actively drilled.

Abstract: A frequency domain geophysical electromagnetic surveying system is provided in which intermittent primary fields having sharp terminations are generated in a cycle having a fundamental frequency by a transmitter, and a receiver includes a gate passing only secondary signals received during interruptions of the primary field, the gated signal being applied to filters tuned to harmonics of the predetermined frequency. The filter outputs are synchronously demodulated to provide signals corresponding to at least the in-phase component of the secondary signal at the fundamental frequency, and preferably in-phase and quadrature components at at least two harmonics. The system can provide improved resolution particularly of the characteristics of in-phase secondary signals received from terrain being surveyed.

Abstract: 1-(4-Butylphenyl)-1-(3,4-methylenedioxyphenyl)-2-nitroalkanes are novel compounds, possessing a broad range of insecticidal effectiveness, which when admixed with 1-(p-alkylphenyl)-1-(p-alkoxyphenyl)-2-nitroalkanes provide synergistic insecticidal compositions effective at low concentrations.