Patents by Inventor Alexandre J.G. Carvalho

Alexandre J.G. Carvalho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions of Allosteric Hemoglobin Modifiers and Methods of Making the Same
    Publication number: 20070293698
    Abstract: The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities.
    Type: Application
    Filed: April 22, 2005
    Publication date: December 20, 2007
    Applicant: ALLOS THERAPEUTICS, INC.
    Inventors: Al Quick, Antonio Santos, Alexandre J.G. Carvalho, Douglas Johnson, Jeffrey Etter, Chris Murray