Patents by Inventor Alexei N. Grinev, deceased

Alexei N. Grinev, deceased has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5198552
    Abstract: A novel compound--ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole- 3- carboxylate hydrochloride monohydrate having the following formula: ##STR1## A process for preparing the compound according to the invention, characterized in that it comprises treating ethyl 5-acetoxy-1,2-dimethylindole-3-carboxylate with a brominating agent in an inert organic solvent under reflux, reacting the resultant ethyl 5-acetoxy-6-bromo-2-bromomethyl-1-methylindole-3-carboxylate with thiophenol in the presence of an alkali metal hydroxide or its alcoholate in an organic solvent, reacting the resultant ethyl 6-bromo-5-hydroxy-1-methyl-2-phenylthiomethylindole-3-carboxylate with an aminomethylating agent in an organic solvent at a temperature of from 65.degree. C. to a temperature of refluxing the reaction mixture. The end product is then isolated from the resultant base--ethyl 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethylindole- 3- carboxylate.
    Type: Grant
    Filed: November 12, 1991
    Date of Patent: March 30, 1993
    Inventors: Fedor A. Trofimov, Nina G. Tsyshkova, Nadezhda S. Bogdanova, Irina S. Nikolaeva, Svetlana A. Zotova, Zinaida M. Sakhaschik, Elena N. Padeiskaya, Alla N. Fomina, Evgenia A. Svirina, Dmitry M. Zlydnikov, Olga I. Kubar, Evgenia G. Shvetsova, Svetlana N. Kutchak, Valentina V. Peters, Elena A. Bryantseva, Anatoly G. Konoplyannikov, Boris P. Surinov, Vera A. Yadrovskaya, Ljudmila S. Safonova, Nina A. Karpova, Elena P. Savina, Ljudmila A. Savinova, Alexei N. Grinev, deceased, Grigory N. Pershin, deceased, Galina V. Grineva, Ellina G. Pershina