Abstract: A method for determining the operating state of a light-emitting implant implanted in the brain of a living being, the light-emitting implant including a light source responsible for emitting light into the brain of the living being, the method using a diagnosing device that includes a receiver of a light signal transmitted through a first eye of the living being and a device for determining the operating state of the light-emitting implant based on the received transmitted light signal.

Abstract: The invention relates to an implantable device for optical stimulation of an organ of the human or animal body, having a probe comprising a tube made of a first transparent material, this tube being hermetically closed by at least one stopper; at least one light source arranged inside the tube; a plurality of electrical connection elements extending through the stopper and electrically connecting said at least one light source to the outside of the tube; and a linking cable arranged outside the tube and connected to said connection elements.

Abstract: A deep brain stimulation device includes a probe having a transparent distal portion, crossed by a channel open at a proximal end of the probe, and also includes electrodes affixed to the distal portion of the probe and electrode terminals affixed to a proximal portion of the probe. Further, the device includes an electrical housing including a channel open at its two ends and housing electrical terminals in contact with the terminals of the probe, and an electrical extension lead affixed to the housing and connected to the terminals of the housing. The channel of the housing is open at the other one of its ends and the device further includes a waveguide at least partly housed in the central channel of the probe, all the way to the distal portion of the probe, and a transmitter housing capable of being connected to the waveguide for the injection of a predetermined wavelength.

Abstract: The invention relates to an implantable device for optical stimulation of an organ of the human or animal body, having a probe comprising a tube made of a first transparent material, this tube being hermetically closed by at least one stopper; at least one light source arranged inside the tube; a plurality of electrical connection elements extending through the stopper and electrically connecting said at least one light source to the outside of the tube; and a linking cable arranged outside the tube and connected to said connection elements.

Abstract: A deep brain stimulation device including: a probe (60) having a transparent distal portion, crossed by a channel (28) open at a proximal end of the probe, and including electrodes (20a, 20b, 20c, 20d) affixed to the distal portion of the probe and electrode terminals (22a, 22b, 22c, 22d) affixed to a proximal portion of the probe; an electrical housing including a channel open at its two ends and housing electrical terminals in contact with the terminals (22a, 22b, 22c, 22d) of the probe; and an electrical extension lead affixed to the housing and connected to the terminals of the housing. The channel of the housing is open at the other one of its ends and the device further includes: a waveguide (50) at least partly housed in the central channel (28) of the probe, all the way to the distal portion of the probe; and a transmitter housing capable of being connected to the waveguide (50) for the injection of a predetermined wavelength.

Abstract: An implantable device for optically stimulating a brain of a human being or animal, including: a multi-channel biocompatible catheter including a plurality of channels extending substantially parallel to each other relative to a longitudinal axis of the multi-channel catheter; a light guide, extending into one channel, for optically stimulating the brain, the multi-channel catheter acting as a sheath totally enveloping the light guide; a functional element, extending into another channel, to measure light injected into a surrounding medium at a distal end of the light guide and/or an element acting on the shape of the multi-channel catheter.

Abstract: The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10?6 g, the instrument comprising an elongated active member (10) with a distal operative end (11) having at least one retaining surface (12) arranged for contacting directly the target tissue or body structure, capturing and retaining molecules of the target tissue or body structure thereto.

Abstract: The main object of the invention is an implantable device of the neural interface type for processing signals, including: a case intended to be held at least partially in a cavity formed on the cranium of a human or animal, an electronic circuit positioned in the case (B), and a system of electrodes coupled electrically to the electronic circuit, wherein the device includes a signal transmission sleeve, extending from the periphery of the case.

Abstract: A transcranial securing device for deep brain stimulation leads comprising: a principal part for securing inside an opening formed in the cranium of a patient; and at least one first securing part housed inside said principal part; said or each securing part comprises at least one axial bore adapted to allow the passage of one or more deep brain stimulation leads; said or at least one securing part is arranged so as to be capable of passing from a first position in which the lead or leads can slide axially in the respective bores, to a second position in which it grips the lead or leads in the respective bore or bores, preventing said sliding.

Abstract: The present invention relates to a method for filtering the signal of neuronal activity during a high frequency deep brain stimulation (DBS) to remove the stimulus artefact in the observed signal, comprising the step of approximating the observed signal trajectories in phase space the observed signal being considered as a sum of the stimulation artifacts induced by the signal of stimulation, wherein the signal of stimulation is assumed to be a solution of an ordinary differential equation including a self-oscillating system with stable limit cycle; slicing the observed signal and its derivative into segments, each segment corresponding to a period of stimulation; collecting N selected periods of stimulation to a training set; estimating the limit cycle of the self-oscillating system; synchronizing each artefact of the observed signal with the estimated limit cycle; subtracting the estimated limit cycle from each artefact in phase space according to the synchronization; collecting all segments in order to obta

Abstract: The invention relates to an implantable device for optically stimulating the brain of a person or an animal, the device comprising: a light source emitting in the near infrared range; and a light guide that is implantable in the brain of a person or an animal, the light guide being provided with a sheath of biocompatible material and having a proximal end for receiving the light emitted by the source, and a distal end for delivering said light to the inside of the brain.

Abstract: A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.

Abstract: A lead for deep electrical neurostimulation comprising a rod of biocompatible material and a blade, also of biocompatible material, secured to one end of the rod and in alignment therewith. The blade presents two main faces and a plurality of electrodes disposed on at least one of the two main faces in a two-dimensional configuration. The electrodes are connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising an electrical pulse generator connected to at least one lead of the above-described type is also disclosed.

Abstract: A system for controlling a machine by cortical signals, including: a mechanism acquiring electrophysiological signals originating from a plurality of locations in the cerebral cortex of a human or animal subject; a producing device adapted to input the electrophysical signals and output control signals from the machine in response to predetermined variations in the characteristics of the electrophysiological signals. At least some of the electrophysiological signals are from predetermined cortex regions and not associated with any performed or imagined activity nor with any sensory stimuli visualized by the human or animal subject. A method for controlling a machine by cortical signals can use such a system.

Abstract: Probe (1) for deep electrical neurostimulation, and more specifically for deep brain electrostimulation, comprising: a tubular body (10) of biocompatible material with a lateral wall (11) defining a lumen (12) and a closed anterior end (13), said tubular body (11) can be introduced for at least a part of its length inside a patient's body for reaching a region to be stimulated; wherein it also comprises: a plurality of electrically insulating arms (32) each bearing at least one electrode (40) and being able to pass from a first position in which they are housed inside of said tubular body (11) to a second position in which they project radially from this latter and inversely; and means (20 and 50) for making said arms (32) pass from said first position to said second position and inversely.

Abstract: A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen.

Abstract: The present invention relates to a method for filtering the signal of neuronal activity during a high frequency deep brain stimulation (DBS) to remove the stimulus artefact in the observed signal, comprising the step of approximating the observed signal trajectories in phase space the observed signal being considered as a sum of the stimulation artefacts induced by the signal of stimulation, wherein the signal of stimulation is assumed to be a solution of an ordinary differential equation including a self-oscillating system with stable limit cycle; slicing the observed signal and its derivative into segments, each segment corresponding to a period of stimulation; collecting N selected periods of stimulation to a training set; estimating the limit cycle of the self-oscillating system; synchronizing each artefact of the observed signal with the estimated limit cycle; subtracting the estimated limit cycle from each artefact in phase space according to the synchronization; collecting all segments in order to obta

Abstract: A transcranial securing device for deep brain stimulation leads comprising: a principal part for securing inside an opening formed in the cranium of a patient; and at least one first securing part housed inside said principal part; said or each securing part comprises at least one axial bore adapted to allow the passage of one or more deep brain stimulation leads; said or at least one securing part is arranged so as to be capable of passing from a first position in which the lead or leads can slide axially in the respective bores, to a second position in which it grips the lead or leads in the respective bore or bores, preventing said sliding.

Abstract: The present invention relates to a sampling instrument adapted for taking a sample in situ and in vivo or taking a sample ex vivo of a target tissue or body structure, in a maximum quantity of less than 10?6 g, said instrument comprising an elongated active member (10) with a distal operative end i11) having at least one retaining surface (12) arranged for contacting directly said target tissue or body structure, capturing and retaining molecules of said target tissue or body structure thereto.

Abstract: A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.