Patents by Inventor Alison Jane Earl

Alison Jane Earl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulatory gene for clavulanic acid biosynthesis
    Patent number: 6361982
    Abstract: DNA comprising a regulatory gene for clavulanic acid biosynthesis. DNA is no greater than 7 kb in length and has the configuration of restriction sites shown in FIG. 1 or a fragment thereof. Use of DNA in a method for producing clavulanic acid in a host.
    Type: Grant
    Filed: August 31, 1995
    Date of Patent: March 26, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Nicola Jane Walters, Barry Barton, Alison Jane Earl
  • DNA encoding ACV synthetase
    Patent number: 6258555
    Abstract: DNA encoding the gene for the synthetase enzyme capable of generating &dgr; (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g. Penicillium chrysogenum, cephalosporium and a Flavobacterium species. The DNA was used to prepare recombinant vectors comprising the ACV synthetase gene and hosts transformed with such vectors. The ACV synthetase gene can form part of a gene cluster comprising other genes involved in -&bgr;-lactam biosynthesis and the production of penicillin by expression of the entire biosynthetic gene cluster for the synthesis of penicillin from primary amino acids is described. Suitable hosts in which expression can take place include heterologous hosts which are naturally non-producers of penicillin.
    Type: Grant
    Filed: August 11, 1997
    Date of Patent: July 10, 2001
    Assignee: Beecham Group p.l.c.
    Inventors: Martin Karl Russell Burnham, Alison Jane Earl, John Henry Bull, David John Smith, Geoffrey Turner
  • Process for producing clavulanic acid
    Patent number: 5869299
    Abstract: A process for preparing clavulanic acid and other clavam derivatives using an enzyme system from Streptomyces, particularly S. Clavuligerus.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: February 9, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Keith Howard Baggaley, Neville Hubert Nicholson, Stephen William Elson, Jeffrey Edwards, Alison Jane Earl, William Henry Holms, David Michael Mousdale, Jack Edward Baldwin, Christopher Schofield
  • DNA molecules and vectors regarding clavulanic acid biosynthesis enzymes
    Patent number: 5759831
    Abstract: DNA sequences obtained from S. clavuligerus, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes encoding one or more enzymes involved in the biosynthesis of clavulanic acid and may be used to improve the yield of clavulanic acid produced by clavulanic acid-producing organisms such as S. clavuligerus ATCC 27064.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: June 2, 1998
    Assignee: Beecham Group p.l.c.
    Inventors: John Edward Hodgson, Alison Jane Earl