Patents by Inventor Allan H.L. Tse

Allan H.L. Tse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of dideoxy nucleoside analogues in the treatment of viral infections
    Patent number: 6156737
    Abstract: The present invention is directed to a method of treating hepatitis B viral infections in mammals comprising the administration of .beta.-L-5-fluoro-2',3'-dideoxycytidine and pharmaceutically acceptable derivatives thereof.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: December 5, 2000
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Allan H.L. Tse
  • Stereoselective synthesis of nucleoside analogues using bicyclic intermediate
    Patent number: 5763606
    Abstract: The present invention relates to a process for producing predominantly pure cis nucleoside analogues of formula (I), wherein X is S, or O; Y is S, CH.sub.2, O or CH(R); wherein R is azido or halogen; and R.sub.2 is a purine or pyrimidine base; via the coupling of a silylated purine or pyrimidine base in the presence of an appropriate Lewis acid with a bicyclic intermediate of formula (III) wherein Z is S or O; followed by conversion of the resulting intermediate of formula (II) to an alkyl ester and reduction to yield a compound of formula (I).
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: June 9, 1998
    Assignee: BioChem Pharma, Inc.
    Inventors: Tarek S. Mansour, Colleen A. Evans, Haolun Jin, M. Arshad Siddiqui, Allan H. L. Tse
  • Processes for the diastereoselective synthesis of nucleoside analogues
    Patent number: 5756706
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: May 26, 1998
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Allan H. L. Tse
  • Nucleoside analogues and synthetic intermediates
    Patent number: 5744596
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 28, 1998
    Assignee: Biochem Pharma Inc.
    Inventors: Tarek Mansour, Allan H. L. Tse
  • Processes for the diastereoselective synthesis of nucleoside analogues
    Patent number: 5696254
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity, and intermediates useful in those processes.
    Type: Grant
    Filed: June 13, 1994
    Date of Patent: December 9, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H. L. Tse, M. Arshad Siddiqui
  • Intermediates in the synthesis of 1,3-oxathiolanyl cytosine nucleoside analogues
    Patent number: 5693787
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 2, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H. L. Tse, M. Arshad Siddiqui
  • Processes for the diastereoselective separation of nucleoside analogue synthetic intermediates
    Patent number: 5663320
    Abstract: The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 2, 1997
    Assignee: BioChem Pharma, Inc.
    Inventors: Tarek Mansour, Haolun Jin, Allan H.L. Tse, M. Arshad Siddiqui