Patents by Inventor Allan Wissner

Allan Wissner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6608048
    Abstract: This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: August 19, 2003
    Assignee: Wyeth Holdings
    Inventors: Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Publication number: 20030149056
    Abstract: This invention provides compounds of Formula (I), represented by the structure 1
    Type: Application
    Filed: November 26, 2002
    Publication date: August 7, 2003
    Applicant: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Middleton Brawner Floyd, Bernard D. Johnson, Elsebe Geraldine Overbeek-Klumpers
  • Patent number: 6548496
    Abstract: This invention provides compounds of formula I having the structure Wherein substitutions at A″, Z, n, and X are set forth in the specification.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: April 15, 2003
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • Publication number: 20030065180
    Abstract: This invention provides compounds of Formula (I), 1
    Type: Application
    Filed: March 28, 2001
    Publication date: April 3, 2003
    Applicant: American Home Products Corporation
    Inventors: Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Patent number: 6521618
    Abstract: This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: February 18, 2003
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Publication number: 20020165229
    Abstract: This invention provides compounds of formula I having the structure 1
    Type: Application
    Filed: December 21, 2001
    Publication date: November 7, 2002
    Applicant: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • Patent number: 6355636
    Abstract: This invention provides compounds of formula I having the structure useful as inhibitors of protein tyrosine kinase.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: March 12, 2002
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Philip R. Hamann, Ayako Yamashita
  • Publication number: 20020026052
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: March 28, 2001
    Publication date: February 28, 2002
    Applicant: American Home Products Corporation
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils Demorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Publication number: 20010051620
    Abstract: This invention provides compounds of formula 1, having the structure 1
    Type: Application
    Filed: December 29, 2000
    Publication date: December 13, 2001
    Applicant: American Home Products Corporation
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Patent number: 6297258
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: October 2, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost
  • Patent number: 6288082
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: September 11, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Mark E. Salvati, Philip Frost
  • Patent number: 6251912
    Abstract: This invention provides compounds of formula 1 having the structure wherein: X, R1, R2, R3, R4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents and in the treatment of certain kidney diseases, such as polycystic kidney disease.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: June 26, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Bernard D. Johnson, Philip R. Hamann, Nan Zhang
  • Patent number: 6002008
    Abstract: This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted;n is 0-1;Y is --NH--, --O--, --S--, or --NR--;R is alkyl of 1-6 carbon atoms;R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy, alkynoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkynoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulfonamido, alkenylsulfonamido, alkynylsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, dialkylamino, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, phenylamino, benzylamino, ##STR2## R.sub.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: December 14, 1999
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Bernard D. Johnson, Marvin F. Reich, Middleton B. Floyd, Jr., Douglas B. Kitchen, Hwei-Ru Tsou
  • Patent number: 5760041
    Abstract: This invention provides a compound having the formula ##STR1## wherein: X is phenyl which is optionally substituted;R and R.sub.1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl;R.sub.2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl;Y is a radical selected from the group consisting of ##STR2## R.sub.3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl;n=2-4;or a pharmaceutically acceptable salt thereof, with the proviso that each R.sub.3 of Y may be the same or different which are useful as antineoplastic agents.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: June 2, 1998
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Bernard D. Johnson, Middleton B. Floyd, Jr., Douglas B. Kitchen
  • Patent number: 5569762
    Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: October 29, 1996
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Michael P. Trova
  • Patent number: 5432189
    Abstract: Bis-aryl amide and urea compounds of the general formula: ##STR1## wherein X is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds are inhibitors of platelet activating factor. Pharmaceutical compositions containing the compounds and methods of treating platelet activating factor associated conditions are also included.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: July 11, 1995
    Assignee: American Cyanamid Company
    Inventor: Allan Wissner
  • Patent number: 5430150
    Abstract: Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease enzymes.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: July 4, 1995
    Assignee: American Cyanamid Company
    Inventors: Michael P. Trova, Robert E. Babine, Nan Zhang, Steven R. Schow, Allan Wissner
  • Patent number: 5428167
    Abstract: The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: June 27, 1995
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Michael P. Trova
  • Patent number: 5411983
    Abstract: The invention is a compound of R or S enantiomers or racemic mixtures of compounds of the formula: ##STR1## wherein: (A) X, Y, and R.sub.3 are as defined in the specification.
    Type: Grant
    Filed: July 28, 1993
    Date of Patent: May 2, 1995
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Robert E. Schaub, Phaik-Eng Sum
  • Patent number: 5350759
    Abstract: Bis-aryl amide and urea compounds of the general formula: ##STR1## wherein X is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds are inhibitors of platelet activating factor. Pharmaceutical compositions containing the compounds and methods of treating platelet activating factor associated conditions are also included.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: September 27, 1994
    Inventor: Allan Wissner