Patents by Inventor Allen Dale Everett
Allen Dale Everett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220202828Abstract: The present invention relates to the field of pulmonary arterial hypertension. More specifically, the present invention provides methods and compositions useful in assessing Insulin-Like Growth Factor (IGF) axis proteins. In one embodiment, a method comprises the steps of (a) detecting an increased level of IGFBP2 relative to a control in a sample obtained from a subject suspected of having PAH; and (b) treating the subject with a PAH therapy.Type: ApplicationFiled: April 29, 2020Publication date: June 30, 2022Inventors: Allen Dale Everett, Jun Yang
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Publication number: 20190310265Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.Type: ApplicationFiled: June 6, 2019Publication date: October 10, 2019Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Jennifer E. Van Eyk, Allen Dale Everett, Zhicheng Jin
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Patent number: 10365288Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.Type: GrantFiled: June 28, 2017Date of Patent: July 30, 2019Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Jennifer E. Van Eyk, Allen Dale Everett, Zhicheng Jin
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Patent number: 10215764Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. In a specific embodiment, the present invention provides an isolated antibody or fragment thereof that specifically binds to neurogranin. In another embodiment, the present invention provides a polynucleotide aptamer that specifically binds neurogranin.Type: GrantFiled: June 30, 2017Date of Patent: February 26, 2019Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Allen Dale Everett, Jun Yang, Zongming Fu
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Patent number: 9885682Abstract: Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may include a detector configured to detect a change in an electrical property on a surface thereof. The detector may be a FET. The system also may include a passive layer disposed on a top surface of the detector. Further, the system may include a hydrophobic layer disposed on the passive layer. The system also may include a receptor-attachment material configured for binding to an analyte. A receptor may bind to the analyte, and the receptor may be attached to the receptor-attachment material. The binding of the analyte to the receptor can cause the change of the electrical property at the surface. In response to the change for example, a current may change for indicating the binding of the analyte to the receptor.Type: GrantFiled: December 3, 2012Date of Patent: February 6, 2018Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Allen Dale Everett, Howard Katz, Kalpana Besar, Weiguo Huang
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Publication number: 20170370943Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.Type: ApplicationFiled: June 28, 2017Publication date: December 28, 2017Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: JENNIFER E. VAN EYK, ALLEN DALE EVERETT, ZHICHENG JIN
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Publication number: 20170315138Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. In a specific embodiment, the present invention provides an isolated antibody or fragment thereof that specifically binds to neurogranin. In another embodiment, the present invention provides a polynucleotide aptamer that specifically binds neurogranin.Type: ApplicationFiled: June 30, 2017Publication date: November 2, 2017Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: ALLEN DALE EVERETT, JUN YANG, ZONGMING FU
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Patent number: 9746481Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. Brain injury can include overt or traumatic brain injury, as well as subclinical brain injury (SCI). In one embodiment, a method for diagnosing SCI in a patient comprises (a) collecting a sample from the patient; (b) measuring the levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises ASTN1, BAI3, CNDP1, ERMIN, GFAP, GRM3, KLH32, MAGE2, NRG3, NRGN, OMG, SLC39A12, RTN1, and MT3; and (c) comparing the levels of the panel of biomarkers with predefined levels of the same panel of biomarkers that correlate to a patient having SCI and predefined levels of the same panel of biomarkers that correlate to a patient not having SCI, wherein a correlation to one of the predefined levels provides the diagnosis.Type: GrantFiled: October 14, 2011Date of Patent: August 29, 2017Assignee: The Johns Hopkins UniversityInventors: Allen Dale Everett, James Francis Casella, Jennifer Van Eyk
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Patent number: 9709578Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. In a specific embodiment, the present invention provides an isolated antibody or fragment thereof that specifically binds to neurogranin. In another embodiment, the present invention provides a polynucleotide aptamer that specifically binds neurogranin.Type: GrantFiled: September 29, 2016Date of Patent: July 18, 2017Assignee: The Johns Hopkins UniversityInventors: Allen Dale Everett, Jun Yang, Zongming Fu
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Patent number: 9709573Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.Type: GrantFiled: March 13, 2013Date of Patent: July 18, 2017Assignee: The Johns Hopkins UniversityInventors: Jennifer E. Van Eyk, Allen Dale Everett, Zhicheng Jin
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Publication number: 20170038397Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. In a specific embodiment, the present invention provides an isolated antibody or fragment thereof that specifically binds to neurogranin. In another embodiment, the present invention provides a polynucleotide aptamer that specifically binds neurogranin.Type: ApplicationFiled: September 29, 2016Publication date: February 9, 2017Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: ALLEN DALE EVERETT, JUN YANG, ZONGMING FU
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Publication number: 20150072360Abstract: Methods are disclosed for predicting or diagnosing pulmonary artery hypertension (PAH) and for determining the efficacy of PAH therapy using biomarkers.Type: ApplicationFiled: December 14, 2012Publication date: March 12, 2015Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Allen Dale Everett, Zongming Fu
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Publication number: 20150051115Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. Brain injury can include overt or traumatic brain injury, as well as subclinical brain injury (SCI). In one embodiment, a method for diagnosing SCI in a patient comprises (a) collecting a sample from the patient, (b) measuring the levels of a panel of biomarkers in the sample collected from the patient, wherein the panel of biomarkers comprises ASTN1, BAI3, CNDP1, ERMIN, GFAP, GRM3, KLH32, MAGE2, NRG3, NRGN, OMG, SLC39A12, RTN1, and MT3; and (c) comparing the levels of the panel of biomarkers with predefined levels of the same panel of biomarkers than correlate to a patient having SCI and predefined levels of the same panel of biomarkers that correlate to a patient not having SCI, wherein a correlation to one of the predefined levels provides the diagnosis.Type: ApplicationFiled: October 27, 2014Publication date: February 19, 2015Inventors: Allen Dale Everett, James Francis Casella, Jennifer van Eyk
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Publication number: 20150031048Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis.Type: ApplicationFiled: March 13, 2013Publication date: January 29, 2015Applicant: The Johns Hopkins UniversityInventors: Jennifer E. Van Eyk, Allen Dale Everett, Zhicheng Jin
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Publication number: 20140349005Abstract: Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may include a detector configured to detect a change in an electrical property on a surface thereof. The detector may be a FET. The system also may include a passive layer disposed on a top surface of the detector. Further, the system may include a hydrophobic layer disposed on the passive layer. The system also may include a receptor-attachment material configured for binding to an analyte. A receptor may bind to the analyte, and the receptor may be attached to the receptor-attachment material. The binding of the analyte to the receptor can cause the change of the electrical property at the surface. In response to the change for example, a current may change for indicating the binding of the analyte to the receptor.Type: ApplicationFiled: December 3, 2012Publication date: November 27, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Allen Dale Everett, Howard Katz, Kalpana Besar, Weiguo Huang
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Publication number: 20140141458Abstract: The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. In a specific embodiment, the present invention provides an isolated antibody or fragment thereof that specifically binds to neurogranin. In another embodiment, the present invention provides a polynucleotide aptamer that specifically binds neurogranin.Type: ApplicationFiled: May 14, 2012Publication date: May 22, 2014Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Allen Dale Everett, Jun Yang, Zongming Fu