Patents by Inventor Ambarish Shah

Ambarish Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200231680
    Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
    Type: Application
    Filed: February 10, 2020
    Publication date: July 23, 2020
    Inventors: Thomas LINKE, William K. WANG, Ambarish SHAH, Hasige SATHISH, Alan HUNTER, Christopher THOMPSON
  • Publication number: 20200216541
    Abstract: Herein described are liquid formulations of antibodies and biologically active fragments thereof that specifically bind to a human ICOS polypeptide, exhibit increased in vivo ADCC activity and undergo reversible self-association in solution.
    Type: Application
    Filed: December 12, 2019
    Publication date: July 9, 2020
    Inventors: Hasige Sathish, Ambarish Shah, Gianluca Carlesso, Tracy Delaney
  • Patent number: 10556955
    Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: February 11, 2020
    Assignee: MedImmune Limited
    Inventors: Thomas Linke, William K. Wang, Ambarish Shah, Hasige Sathish, Alan Hunter, Christopher Thompson
  • Publication number: 20190382494
    Abstract: Provided herein are compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making and using such compositions. In various aspects, stable coformulations of the anti-PD-L1 antibody durvalumab (MEDI4736) and the anti-CTLA-4 antibody tremelimumab are provided.
    Type: Application
    Filed: August 28, 2019
    Publication date: December 19, 2019
    Inventors: JIALI DU, AMBARISH SHAH
  • Patent number: 10421811
    Abstract: Provided herein are compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making and using such compositions. In various aspects, stable coformulations of the anti-PD-L1 antibody durvalumab (MEDI4736) and the anti-CTLA-4 antibody tremelimumab are provided.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: September 24, 2019
    Assignee: MEDIMMUNE, LLC
    Inventors: Jiali Du, Ambarish Shah
  • Publication number: 20180371094
    Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
    Type: Application
    Filed: September 7, 2018
    Publication date: December 27, 2018
    Inventors: Thomas LINKE, William K. WANG, Ambarish SHAH, Hasige SATHISH, Alan HUNTER, Christopher THOMPSON
  • Patent number: 10072083
    Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: September 11, 2018
    Assignee: MedImmune, LLC
    Inventors: Thomas Linke, William K. Wang, Ambarish Shah, Hasige Sathish, Alan Hunter, Christopher Thompson
  • Publication number: 20180243415
    Abstract: Disclosed here are methods and systems for improving the aggregation profile in a liquid antibody formulation. In one embodiment, the antibody is a fully monoclonal antibody that binds to Angiopoietin-2.
    Type: Application
    Filed: January 3, 2018
    Publication date: August 30, 2018
    Inventors: Priyanka MALLIK, Ambarish SHAH, Anthony TUESCA
  • Publication number: 20170306025
    Abstract: Provided herein are compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making and using such compositions. In various aspects, stable coformulations of the anti-PD-L1 antibody durvalumab (MEDI4736) and the anti-CTLA-4 antibody tremelimumab are provided.
    Type: Application
    Filed: April 24, 2017
    Publication date: October 26, 2017
    Inventors: Jiali DU, Ambarish Shah
  • Publication number: 20170174766
    Abstract: Herein described as liquid formulations of antibodies and biologically active fragments thereof that specifically bind to human ICOS polypeptide, exhibit increased in vivo ADCC activity and undergo reversible self-association in solution.
    Type: Application
    Filed: December 12, 2016
    Publication date: June 22, 2017
    Inventors: Hasige Sathish, Ambarish Shah, Gianluca Carlesso, Tracy Delaney
  • Publication number: 20170145100
    Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography. The present invention also provides compositions, formulations, and unit dosage forms comprising the purified polypeptide or immunoconjugate.
    Type: Application
    Filed: February 3, 2017
    Publication date: May 25, 2017
    Inventors: Thomas LINKE, William K. WANG, Ambarish SHAH, Hasige SATHISH, Alan HUNTER, Christopher THOMPSON
  • Patent number: 9580461
    Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: February 28, 2017
    Assignee: MedImmune, LLC
    Inventors: Thomas Linke, William K. Wang, Ambarish Shah, Hasige Sathish, Alan Hunter, Christopher Thompson
  • Publication number: 20160215051
    Abstract: The present invention relates to methods of minimizing the aggregation of BiTE® molecules in solution. In one embodiment, a method of the invention is used to minimize the aggregation of BiTE® molecules in solution. In another embodiment, a method of the invention is used to minimize the aggregation of BiTE® molecules comprising a first and a second binding site specific for the CD3 and CD19 antigens, respectively, wherein said molecule is in solution. In a specific embodiment, the present invention provides methods to minimize the aggregation of the MT103™ BiTE® molecule in solution.
    Type: Application
    Filed: March 8, 2016
    Publication date: July 28, 2016
    Inventors: Monika S. SHARMA, Ambarish SHAH, Scott HAMMOND
  • Patent number: 9308257
    Abstract: The present invention provides stable lyophilized formulations of bispecific antibodies or fragments thereof.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: April 12, 2016
    Assignee: MedImmune, LLC
    Inventors: Monika S. Sharma, Sr., Ambarish Shah, Scott Hammond
  • Publication number: 20150344557
    Abstract: Disclosed here are methods and systems for improving the aggregation profile in a liquid antibody formulation. In one embodiment, the antibody is a fully monoclonal antibody that binds to Angiopoietin-2.
    Type: Application
    Filed: December 18, 2013
    Publication date: December 3, 2015
    Inventors: Priyanka Malik, Ambarish Shah, Anthony Tuesca
  • Publication number: 20130202626
    Abstract: The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.
    Type: Application
    Filed: July 27, 2011
    Publication date: August 8, 2013
    Applicant: MEDIMMUNE, LLC
    Inventors: Thomas Linke, William K. Wang, Ambarish Shah, Hasige Sathish, Alan Hunter, Christopher Thompson
  • Publication number: 20120148576
    Abstract: The present invention provides stable liquid formulations comprising chimeric and humanized versions of anti-CD 19 mouse monoclonal antibodies that may mediate ADCC, CDC, and/or apoptosis for the treatment of B cell diseases and disorders.
    Type: Application
    Filed: March 8, 2010
    Publication date: June 14, 2012
    Applicant: Medlmmune, LLC
    Inventors: Monika S. Sharma, Ambarish Shah
  • Publication number: 20110293605
    Abstract: Herein described are liquid formulations of antibodies and biologically active fragments thereof that specifically bind to a human ICOS polypeptide, exhibit increased in vivo ADCC activity and undergo reversible self-association in solution.
    Type: Application
    Filed: November 12, 2009
    Publication date: December 1, 2011
    Inventors: Hasige Sathish, Ambarish Shah, Gianluca Carlesso, Tracy Delaney
  • Publication number: 20100303827
    Abstract: The present invention provides stable lyophilized formulations of bispecific antibodies or fragments thereof.
    Type: Application
    Filed: November 26, 2008
    Publication date: December 2, 2010
    Applicant: One Medimmune Way
    Inventors: Monika S. Sharma, SR., Ambarish Shah, Scott Hammond