Patents by Inventor Amin M. Khan

Amin M. Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-METHYL-D-ASPARTATE RECEPTOR MODULATORS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170210779
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Inventor: Amin M. Khan
  • Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists
    Patent number: 5663350
    Abstract: The present invention relates to a novel process for the preparation of highly potent histamine receptor antagonists, in particular histamine H.sub.3 -receptor antagonists. Also disclosed is a novel process for the preparation of intermediates useful in the preparation of histamine receptor antagonists, in particular H.sub.3 -receptor antagonists.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: September 2, 1997
    Assignee: The University of Toledo
    Inventors: Graham J. Durant, Amin M. Khan
  • 4-[4'-piperodinyl or 3'-pirrolidinyl] substituted imidazoles as H.sub.3 -receptor antagonists and therapeutic uses thereof
    Patent number: 5639775
    Abstract: Diazolyl compounds having activity as histamine H3-receptor antagonists, pharmaceutical compositions and methods of using such compounds for treating cognitive disorder or attention or arousal deficit.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: June 17, 1997
    Assignee: The University of Toledo
    Inventors: Graham J. Durant, Amin M. Khan
  • Histamine H.sub.3 -receptor antagonists and therapeutic uses thereof
    Patent number: 5633382
    Abstract: The present invention provides novel compounds having activity as histamine H.sub.3 -receptor antagonists. The novel compounds include 4-imidazolyl-N-substituted pyrrolidines, piperidines, and cycloheptimides. The preferred compounds are 4-imidazolyl-N-(cycloalkyl/aryl-alkyl-carbonyl) piperidines such as 4-(1-cyclohexylvaleryol-4-piperidyl)-1H-imidazole.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: May 27, 1997
    Assignee: The University of Toledo
    Inventors: Graham J. Durant, Amin M. Khan
  • Histamine H.sub.3 -receptor antagonists and therapeutic uses thereof
    Patent number: 5486526
    Abstract: The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H.sub.3 -receptor antagonists. Such compounds have affinity for histamine H.sub.3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H.sub.3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: January 23, 1996
    Assignees: The University of Toledo, Gliatech, Inc.
    Inventors: Graham J. Durant, Amin M. Khan, Clark E. Tedford
  • Process for the preparation of intermediates useful for the synthesis of histamine receptor antagonists
    Patent number: 5380858
    Abstract: The present invention relates to a novel process for the preparation of highly potent histamine receptor antagonists, in particular histamine H.sub.3 receptor antagonists. Also disclosed is a novel process for the preparation of intermediates useful in the preparation of histamine receptor antagonists, in particular H.sub.3 -receptor antagonists.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: January 10, 1995
    Assignee: The University of Toledo
    Inventors: Graham J. Durant, Amin M. Khan