Patents by Inventor AmirAli Hajhossein Talasaz
AmirAli Hajhossein Talasaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11519031Abstract: Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.Type: GrantFiled: August 24, 2020Date of Patent: December 6, 2022Assignee: Illumina, Inc.Inventors: AmirAli Hajhossein Talasaz, Gordon M. Cann
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Publication number: 20210032696Abstract: Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.Type: ApplicationFiled: August 24, 2020Publication date: February 4, 2021Inventors: AmirAli Hajhossein Talasaz, Gordon M. Cann
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Patent number: 10781485Abstract: Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.Type: GrantFiled: April 20, 2018Date of Patent: September 22, 2020Assignee: Illumina, Inc.Inventors: AmirAli Hajhossein Talasaz, Gordon M. Cann
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Patent number: 10167505Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.Type: GrantFiled: March 10, 2016Date of Patent: January 1, 2019Assignee: ILLUMINA, INC.Inventors: Min-Jui Richard Shen, Robert C. Kain, Kenneth M. Kuhn, AmirAli Hajhossein Talasaz, Arash Jamshidi, George Sakaldasis, Eric Vermaas, Sebastian Bohm, Tarun Khurana, Helmy A. Eltoukhy, Jian Gong
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Publication number: 20180237852Abstract: Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.Type: ApplicationFiled: April 20, 2018Publication date: August 23, 2018Inventors: AmirAli Hajhossein Talasaz, Gordon M. Cann
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Patent number: 9982295Abstract: Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.Type: GrantFiled: July 17, 2015Date of Patent: May 29, 2018Assignee: Illumina, Inc.Inventors: AmirAli Hajhossein Talasaz, Gordon M. Cann
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Publication number: 20160237489Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.Type: ApplicationFiled: March 10, 2016Publication date: August 18, 2016Applicant: Illumina, Inc.Inventors: Min-Jui Richard Shen, Robert C. Kain, Kenneth M. Kuhn, AmirAli Hajhossein Talasaz, Arash Jamshidi, George Sakaldasis, Eric Vermaas, Sebastian Bohm, Tarun Khurana, Helmy A. Eltoukhy, Jian Gong
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Publication number: 20160186253Abstract: Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or more sequences of interest in a test sample that comprises a mixture of fetal cellular DNA and mother-and-fetus cfDNA. In some embodiments, methods are provided for determining whether the fetus has a genetic disease. In some embodiments, methods are provided for determining whether the fetus is homozygous in a disease causing allele when the mother is heterozygous of the same allele. In some embodiments, methods are provided for determining whether the fetus has a copy number variation (CNV) or a non-CNV genetic sequence anomaly.Type: ApplicationFiled: July 17, 2015Publication date: June 30, 2016Inventors: AmirAli Hajhossein Talasaz, Gordon M. Cann
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Patent number: 9309571Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.Type: GrantFiled: November 19, 2013Date of Patent: April 12, 2016Assignee: Illumina, Inc.Inventors: Min-Jui Richard Shen, Robert C. Kain, Kenneth M. Kuhn, AmirAli Hajhossein Talasaz, Arash Jamshidi, George Sakaldasis, Eric Vermaas, Sebastian Bohm, Tarun Khurana, Helmy A. Eltoukhy, Jian Gong
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Patent number: 9267943Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.Type: GrantFiled: October 28, 2011Date of Patent: February 23, 2016Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz
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Publication number: 20140073514Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.Type: ApplicationFiled: November 19, 2013Publication date: March 13, 2014Applicant: ILLUMINA, INC.Inventors: Min-Jui Richard Shen, Robert C. Kain, Kenneth M. Kuhn, AmirAli Hajhossein Talasaz, Arash Jamshidi, George Sakaldasis, Eric Vermaas, Sebastian Bohm, Tarun Khurana, Helmy A. Eltoukhy, Jian Gong
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Patent number: 8637242Abstract: Provided are methods and apparatuses for performing sequencing using droplet manipulation, for example, via electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing.Type: GrantFiled: November 6, 2012Date of Patent: January 28, 2014Assignee: Illumina, Inc.Inventors: Min-Jui Richard Shen, Robert C. Kain, Kenneth M. Kuhn, AmirAli Hajhossein Talasaz, Arash Jamshidi
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Publication number: 20120045828Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.Type: ApplicationFiled: October 28, 2011Publication date: February 23, 2012Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz
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Patent number: 8071395Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.Type: GrantFiled: December 11, 2008Date of Patent: December 6, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz
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Publication number: 20090220979Abstract: Described here is an automated robotic device that isolates circulating tumor cells (CTCs) or other biological structures with extremely high purity. The device uses powerful magnetic rods covered in removable plastic sleeves. These rods sweep through blood samples, capturing, e.g., cancer cells labeled with antibodies linked to magnetically responsive particles such as superparamagnetic beads. Upon completion of the capturing protocol, the magnetic rods undergo several rounds of washing, thereby removing all contaminating blood cells. The captured target cells are released into a final capture solution by removing the magnetic rods from the sleeves. Additionally, cells captured by this device show no reduced viability when cultured after capture. Cells are captured in a state suitable for genetic analysis. Also disclosed are methods for single cell analysis. Being robotic allows the device to be operated with high throughput.Type: ApplicationFiled: December 11, 2008Publication date: September 3, 2009Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ronald W. Davis, Stefanie S. Jeffrey, Michael N. Mindrinos, R. Fabian Pease, Ashley Ann Powell, AmirAli Hajhossein Talasaz