Abstract: A method of making a dielectric substrate array for conducting a plurality of reactions in parallel in a number of wells, the method comprising: forming a first passage and a second passage each extending through a dielectric substrate, the substrate having a first surface and an opposing second surface; forming a plurality of channels on said first or second surface, including a first channel, a second channel, a third channel and a fourth channel on the substrate, wherein the first channel is on the first surface and intersects with the first passage, wherein the second channel is on the second surface and intersects with both of the first passage and the second passage, wherein the third channel is on the first surface and intersects with the second passage, wherein the fourth channel is on the first surface and is located between the outlets of the first and second passage at the first surface, and wherein (a) the connected first channel, first passage, second channel, second passage and third channel def

Abstract: Methods are provided for synthesizing a plurality of compounds in parallel. The methods use cross-over channels for moving samples from a reservoir of starting materials into a plurality of wells. The movement is achieved, for example, using an electrokinetic pump.