Patents by Inventor Amy W. Wang

Amy W. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7601286
    Abstract: A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: October 13, 2009
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: William Benett, Peter Krulevitch, Mariam Maghribi, Julie Hamilton, Klint Rose, Amy W. Wang
  • Patent number: 6576459
    Abstract: A sample preparation and analysis device which incorporates both immunoassays and PCR assays in one compact, field-portable microchip. The device provides new capabilities in fluid and particle control which allows the building of a fluidic chip with no moving parts, thus decreasing fabrication cost and increasing the robustness of the device. The device can operate in a true continuous (not batch) mode. The device incorporates magnetohydrodynamic (MHD) pumps to move the fluid through the system, acoustic mixing and fractionation, dielectropheretic (DEP) sample concentration and purification, and on-chip optical detection capabilities.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: June 10, 2003
    Assignee: The Regents of the University of California
    Inventors: Robin R. Miles, Amy W. Wang, Christopher K. Fuller, Asuncion V. Lemoff, Kerry A. Bettencourt, June Yu
  • Patent number: 6480730
    Abstract: An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: November 12, 2002
    Assignee: The Regents of the University of California
    Inventors: Christopher B. Darrow, Joe H. Satcher, Jr., Stephen M. Lane, Abraham P. Lee, Amy W. Wang
  • Publication number: 20020134907
    Abstract: A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure.
    Type: Application
    Filed: March 26, 2002
    Publication date: September 26, 2002
    Applicant: The Regents of the University of California
    Inventors: William Benett, Peter Krulevitch, Mariam Maghribi, Julie Hamilton, Klint Rose, Amy W. Wang
  • Publication number: 20020137196
    Abstract: A sample preparation and analysis device which incorporates both immunoassays and PCR assays in one compact, field-portable microchip. The device provides new capabilities in fluid and particle control which allows the building of a fluidic chip with no moving parts, thus decreasing fabrication cost and increasing the robustness of the device. The device can operate in a true continuous (not batch) mode. The device incorporates magnetohydrodynamic (MHD) pumps to move the fluid through the system, acoustic mixing and fractionation, dielectropheretic (DEP) sample concentration and purification, and on-chip optical detection capabilities.
    Type: Application
    Filed: March 23, 2001
    Publication date: September 26, 2002
    Applicant: The Regents of the University of California
    Inventors: Robin R. Miles, Amy W. Wang, Christopher K. Fuller, Asuncion V. Lemoff, Kerry A. Bettencourt, June Yu
  • Patent number: 6454759
    Abstract: A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: September 24, 2002
    Assignee: The Regents of the University of California
    Inventors: Peter A. Krulevitch, Amy W. Wang
  • Publication number: 20010044620
    Abstract: A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.
    Type: Application
    Filed: February 28, 2001
    Publication date: November 22, 2001
    Applicant: The Regents of the University of California
    Inventors: Peter A. Krulevitch, Amy W. Wang
  • Publication number: 20010016683
    Abstract: An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.
    Type: Application
    Filed: December 20, 2000
    Publication date: August 23, 2001
    Inventors: Christopher B Darrow, Joe H. Satcher, Stephen M. Lane, Abraham P. Lee, Amy W. Wang
  • Patent number: 6201980
    Abstract: An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: March 13, 2001
    Assignee: The Regents of the University of California
    Inventors: Christopher B. Darrow, Joe H. Satcher, Jr., Stephen M. Lane, Abraham P. Lee, Amy W. Wang