Abstract: The present invention relates to phenyl [a]indole[2,3-g]quinolizine compounds represented by formula (I), a preparation method therefor, a pharmaceutical composition, and applications thereof. Specific applications are applications in the preparation of drugs for treating diseases related to a proprotein convertase subtilisin Kexin-9 (PCSK9), comprising the applications in the preparation of drugs for treating hyperlipemia, hypercholesterolemia, hypertriglyceridemia, fatty liver deformation, atherosclerosis, obesity and other metabolic diseases.

Abstract: A heating device and a low-temperature baked smoking set are disclosed, the heating device includes a heating compartment and an electromagnetic inductive coil that is wound around a periphery of the heating compartment; the electromagnetic inductive coil at least includes a first inductive coil and a second inductive coil; the first inductive coil and the second inductive coil are wound around two parts of the periphery of the heating compartment, extending in an axial direction of the heating compartment; turns of the first inductive coil is more than turns of the second inductive coil such that heating speeds of two parts of the periphery of the heating compartment are different.

Abstract: A method of identifying a therapeutic compound for treating cancer in a human subject, the method including: providing a device that measures cell-substrate impedance; culturing cancer cells in the at least two wells, wherein the cancer cells are obtained from a human subject and have a receptor tyrosine kinase (RTK) pathway; adding to a first well a proposed therapeutic compound that affects an RTK pathway and an RTK stimulating factor for the RTK pathway to form a test well, and adding to another well the RTK stimulating factor to form a control well; continuously monitoring cell-substrate impedance of the at least two wells; and determining a difference in impedance or optionally in cell index between the test well and control well; and if significantly different, concluding the proposed therapeutic compound is therapeutically active in the RTK pathway within the cancer cells of the human subject.

Abstract: An LED filament light bulb, comprising: a lamp housing with inner surface and outer surface opposite to the inner surface of the lamp housing, the lamp housing includes a layer of luminescent material, which is formed on the inner surface or the outer surface of the lamp housing or integrated in the material of the lamp housing; a bulb base connected to the lamp housing; a stem connected to the bulb base and located in the lamp housing; and a single filament, disposed in the light housing, the LED filament comprising: a plurality of LED filament units, wherein each of the plurality of LED filament units includes a single LED chip with an upper surface and a lower surface opposite to the upper surface. The LED filament light bulb further comprising a plurality of supporting arms, connected with and supporting the LED filament, wherein the stem comprises a stand extending to the center of the lamp housing, the stand supports the supporting arms.

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

Abstract: A medical imaging device having a bore 104 for receiving a patient during a medical imaging process and a ventilation channel 216 having an opening within the upper circumference of the bore for supplying cool air into the bore. At least one lighting circuit 210 with one or more LEDs is positioned within the ventilation channel 216 and is configured to illuminate the entire length of the bore 104. Air supplied from the ventilation channel 216 cools the lighting circuit 210 and prevents overheating effects within the lighting circuit that are caused by fields generated during the medical imaging process. The lighting circuit 210 comprises one or more filters, wherein the resonance frequency of the medical imaging device is within the stopband of the filters.

Abstract: This disclosure provides a method, apparatus, device, and storage medium for voice interaction, where the method is applied to an AI device to determine whether a current scenario of the AI device is a preset scenario and waken a voice interaction function of the AI device to facilitate voice interaction with a user in response to the current scenario of the AI device being the preset scenario. A scenario directly triggers the voice interaction process, thereby avoiding the process of wakening by physical wakening or a wakening word, simplifying the process of using voice interaction, reducing the costs of learning voice interaction, and improving user experience.

Abstract: Disclosed is a flexible surgical instrument system based on a continuous body structure, the flexible surgical instrument system comprising a flexible surgical instrument and a driving unit. The flexible surgical instrument comprises a flexible continuous body structure composed of a distal structural body, a proximal structural body and a middle connecting body. The distal structural body comprises a distal structural segment, the distal structural segment comprising a distal spacing disk, a distal fixing disk and structural backbones. The proximal structural body comprises a proximal structural segment, the proximal structural segment comprising a proximal spacing disk, a proximal fixing disk and structural backbones. The middle connecting body comprises channel fixing plates and a structural backbone guide channel. The driving unit comprises a motor part, a motion conversion part and a plurality of linear motion mechanisms. The motor part comprises a first fixing plate and a first motor.

Abstract: A gas-dissolved liquid producing apparatus 1 includes a gas supply unit 2, a first liquid supply unit 3, a gas-dissolved liquid generator 4, a second liquid generator 20, a second liquid supply unit 21, a flow rate measuring unit 14, and a controller 23. The controller 23 controls the supply amount of the first liquid to be supplied to the gas-dissolved liquid generator 4 according to the flow rate of circulated gas-dissolved liquid measured by the flow rate measuring unit 14. The gas-dissolved liquid generator 4 dissolves gas supplied from the gas supply unit 2 in first liquid supplied from the first liquid supply unit 3 and second liquid supplied from the second liquid supply unit 21 to generate gas-dissolved liquid.

Abstract: The present invention provides a method for entering text based on an image. The method includes a recognition parameter, corresponding to at least one region in an image, is acquired, the recognition parameter includes text contents recognized from the at least one region and location information associated with the at least one region. An entry location is selected in an entry page, and the following steps are performed: a parameter value, shared by a plurality of tag pages, is acquired; and according to the parameter value shared by the plurality of tag pages, a display page is automatically located to a region corresponding to the selected entry location. The parameter value shared by the plurality of tab pages comprises location information corresponding to the selected entry location. Based on the location information corresponding to the selected entry location and the recognition parameter, text contents to be entered are determined.

Abstract: A flexible continuum structure capable of realizing a posture feedback is provided. The flexible continuum structure can comprise a flexible continuum structure body and a posture feedback mechanism. The flexible continuum structure body can comprise a distal structural body, a proximal structural body and a middle connecting body. The distal structural body can comprise distal spacing disks, a distal fixation disk and distal structural backbones. The proximal structural body can comprise proximal spacing disks, a proximal fixation disk and proximal structural backbones. The middle connecting body can comprise a proximal guide channel fixing plate, a distal guide channel fixing plate and a structural backbone guide channel. One end of the structural backbone is connected to the proximal fixation disk, and the other end passes through the proximal spacing disks, the structural backbone guide channel and the distal spacing disks and is then securely connected to the distal fixation disk.

Abstract: An autonomous drive system for a vehicle includes at least one environment perception sensor, a perception module, a location module, an intention prediction module, and a control module. The perception module is configured to receive signals from the at least one environment perception sensor and detect and track at least two remote vehicles in one or both of a current lane and a neighboring lane. The location module is configured to determine a location of the vehicle. The intention prediction module is configured to generate predicted trajectories for the at least two remote vehicles. The control module is configured to receive signals from the at least one environment perception sensor and receive the predicted trajectories from the intention prediction module. The control module determines a location and time for a lane change based on the predicted trajectories and controls the vehicle to change lanes at the determined location and time.

Abstract: Embodiments of the present disclosure provide an array substrate, a method of manufacturing the same, a liquid crystal display panel, and a display device. The array substrate includes: a base substrate, a data line disposed on the base substrate and a pixel electrode layer disposed on a layer in which the data line is located. The pixel electrode layer includes a plurality of columns of pixel electrodes that are spaced apart from one another. An orthographic projection of the data line on the base substrate covers an orthographic projection of a gap between two adjacent columns of pixel electrodes on the base substrate, and a width of the data line is greater than a width of the gap between two adjacent columns of pixel electrodes.

Abstract: A method of forming a semiconductor structure includes forming a plurality of vertical field-effect transistors (VFETs) disposed on a substrate and forming a plurality of resistive elements disposed over top surfaces of the VFETs. Each pair of a given one of the plurality of VFETs and a corresponding resistive element disposed over the given VFET provides a resistive random access memory (ReRAM) cell. The VFETs are arranged in two or more columns and two or more rows, wherein each column of VFETs provides a bitline of the ReRAM cells sharing a bottom source/drain region and wherein each row of VFETs provides a wordline of the ReRAM cells sharing a gate. Top source/drain regions of the VFETs provide bottom contacts for the resistive elements disposed over the VFETs.

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) one Fab domain capable of specific binding to a target cell antigen, (b) a Fc domain composed of a first and a second subunit capable of stable association, and (c) a first polypeptide comprising two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and a second polypeptide comprising one ectodomain of said TNF ligand family member or a fragment thereof, wherein the first polypeptide is fused at its N-terminus to the C-terminus of one of the subunits of the Fc domain and wherein the second polypeptide is fused at its N-terminus to the C-terminus of the other subunit of the Fc domain, wherein the TNF family ligand trimer-containing antigen binding molecule is monovalent for the binding to the target cell antigen.

Abstract: Embodiments of the present invention are directed to a method that incorporates a germanium pull-out process to form semiconductor structures having stacked silicon nanotubes. In a non-limiting embodiment of the invention, a sacrificial layer is formed over a substrate. The sacrificial layer includes a first type of semiconductor material. A pull-out layer is formed on the sacrificial layer. The first type of semiconductor material from the sacrificial layer is removed to form a silicon-rich layer on a surface of the sacrificial layer. The sacrificial layer can be removed such that the silicon-rich layer defines a silicon nanotube.

Abstract: A desk platform structure for a fitness bike, including a desk platform, a desk platform fixing and sliding mechanism and a supporting rod is provided. The desk platform fixing and sliding mechanism includes a pair of fixing bars, a pair of sliding rails, and a fixing rack. The desk platform is installed on the fixing bars which are installed on the sliding rails. The sliding rails are fixed on guiding bars at two sides of the fixing rack which is connected to the supporting rod. A braking mechanism and a control mechanism for sliding and positioning of the fixing bar are disposed between the fixing bar and the fixing rack. Accordingly, the desk platform is more stable and reliable, and may slide and be positioned at any location. It is convenient to use the desk platform by further adjusting the inclination angle of the desk platform.

Abstract: A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.

Abstract: The invention involves a scale collection device that is located within downflow reactor head for removing solids from feed streams to increase reactor operating cycle time without impact on effective reactor space for catalyst loading. More particularly, a filtering zone is located in an upper portion of a reactor vessel above a rough liquid distribution tray and a distribution tray.

Abstract: A pulse tube cryocooler is furnished with a second-stage cooling stage and an insert. The second-stage cooling stage has a lateral-surface opening, and a first heat-exchange surface extending in a sideways direction from the lateral-surface opening into the second-stage cooling stage. The insert includes a base-end portion fixedly fitted into the second-stage cooling stage to plug the lateral-surface opening, and a second heat-exchange surface that extends in the sideways direction from the base-end portion and is disposed inside the second-stage cooling stage, opposing the first heat-exchange surface. Between the first heat-exchange surface and the second heat-exchange surface the insert forms a clearance that flows a working gas, bringing both the first heat-exchange surface and the second heat-exchange surface into contact with the working gas.