Abstract: An inhaler is disclosed wherein medicament in a flat-bottomed container is aerosolized with a vibrator piezoelectric transducer. The transducer is driven by a signal that excites multiple harmonic frequencies to create a complex pattern of oscillations. A circuit for generating the drive signal to the transducer is also disclosed.

Abstract: A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism.

Abstract: A pharmaceutical delivery package comprising fixed unit dose quantities of two or more different active pharmaceutical ingredients (a) combined in a single delivery package, and (b) segregated from one another within said package wherein said package comprises a core containing a first active pharmaceutical ingredient surrounded at least in part by a capsule containing said second active pharmaceutical ingredient.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: A dry powder inhaler consisting of first chamber having an orifice for holding a dry powder and a gas, and a second chamber for receiving a deaggregated form of the dry powder and for communicating the deaggregated dry powder to a user. A synthetic jet drives the dry powder from the first chamber to the second chamber.

Abstract: A dry powder inhaler consisting of first chamber having an orifice for holding a dry powder and a gas, and a second chamber for receiving a deaggregated form of the dry powder and for communicating the deaggregated dry powder to a user. A synthetic jet drives the dry powder from the first chamber to the second chamber.

Abstract: An fluid sensor to activate and control various components of an inhalation device. The fluid sensor includes an acoustic element, such as a microphone, positioned within said inhalation device to detect fluid within the device and output signals representative of the frequency, direction and/or amplitude of the fluid. These signals control and activate an electrostatic plate and/or a high frequency vibrator.

Abstract: An inhalation device is described for use with a medication pack wherein the medication pack is formed by a single sheet folded on itself into several sealed pockets or pleats. Each of the pockets or pleats contains a drug to be aerosolized using a piezoelectric element. The inhaler includes a mechanism to open the blisters by pulling apart the sealed pocket or pleat.

Abstract: Two or more drugs of different particle size are packaged for co-administration to the respiratory pathway.

Abstract: An inhaler includes a vibrator to deaggregated medication in powder form. One embodiment of the inhaler includes a piezoelectric vibrator 54 for vibrating a diaphragm for imparting vibration to a powder, and a controller 70 for controlling vibration so as to optimally suspend at least a portion of said powder in a fluidized state. An electrostatic charge plate 32 draws powder of selected particle size into the inhalation stream.