Patents by Inventor Ananda M. Chakrabarty

Ananda M. Chakrabarty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080213185
    Abstract: The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.
    Type: Application
    Filed: July 19, 2006
    Publication date: September 4, 2008
    Inventors: Chang Soo Hong, Tohru Yamada, Arsenio M. Fialho, Tapas K. Das Gupta, Ananda M. Chakrabarty
  • Publication number: 20080182782
    Abstract: Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
    Type: Application
    Filed: August 25, 2006
    Publication date: July 31, 2008
    Inventors: Ananda M. Chakrabarty, Tapas K. Das Gupta, Vasu Punj, Olga Zaborina, Yoshinori Hiraoka, Tohru Yamada
  • Publication number: 20080103087
    Abstract: The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.
    Type: Application
    Filed: July 19, 2006
    Publication date: May 1, 2008
    Inventors: Rajeshwari R. Mehta, Brad N. Taylor, Tohru Yamada, Craig W. Beattie, Tapas K. Das Gupta, Ananda M. Chakrabarty
  • Patent number: 7084105
    Abstract: Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: August 1, 2006
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Ananda M. Chakrabarty, Tapas K. Das Gupta, Vas Punj, Olga Zaborina
  • Publication number: 20020110872
    Abstract: Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death. The present inventors have found that different pathogens produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
    Type: Application
    Filed: January 15, 2002
    Publication date: August 15, 2002
    Inventors: Ananda M. Chakrabarty, Tapas K. Das Gupta, Vasu Punj, Olga Zaborina
  • Patent number: 5013654
    Abstract: A novel strain of Pseudomonas aeruginosa, designated as strain SB-1, is capable of growth on hydrocarbon substrates having 10 to 32 or more carbon atoms, during which growth there is secreted into the culture medium an emulsifier which can be recovered and used for such applications as reducing the viscosity of crude oil in secondary recovery methods, as well as in oil spill management and the cleaning of oil-contaminated vessels and pipelines. A novel mutant strain of P. aeruginosa SB-1, designated SB-3, has the property of growing on solid (C.sub.20 +) paraffins but not on liquid alkanes. The selective degradation by strain SB-3 of the solid paraffinic components in crude oil is advantageous in reducing the viscosity of the oil for improving the recovery thereof from oil wells. A novel revertant strain of P.
    Type: Grant
    Filed: March 5, 1990
    Date of Patent: May 7, 1991
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Santimoy Banerjee, Jeffrey S. Karns, Ananda M. Chakrabarty
  • Patent number: 4535061
    Abstract: Plasmid-assisted molecular breeding procedures for generating pure and mixed cultures of microorganisms capable of dissimilating environmentally persistent chemical compounds. Continuously cultured growth of microorganisms is carried out in the presence of a source of DNA plasmids participative in dissimilation of compounds structurally analogous to the persistent compounds and under chemostatic conditions including gradually increasing concentrations of the persistent compound. Novel microorganism products of the procedures include a mixed Arthrobacter and Pseudomonas culture, A.T.C.C. 39028, capable of total degradation of mixed polychlorinated biphenyls (e.g., Arochlor 1221) and a pure culture of Pseudomonas cepacia, A.T.C.C. 39027, which can utilize 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) as its sole carbon source. Disclosed also are procedures for using pure and mixed cultures of the invention in degrading persistent compounds contaminating soil and aqueous environments.
    Type: Grant
    Filed: December 28, 1981
    Date of Patent: August 13, 1985
    Assignee: University of Illinois Foundation
    Inventors: Ananda M. Chakrabarty, Scott T. Kellogg
  • Patent number: 4259444
    Abstract: Unique microorganisms have been developed by the application of genetic engineering techniques. These microorganisms contain at least two stable (compatible) energy-generating plasmids, these plasmids specifying separate degradative pathways. The techniques for preparing such multi-plasmid strains from bacteria of the genus Pseudomonas are described. Living cultures of two strains of Pseudomonas (P. aeruginosa [NRRL B-5472] and P. putida [NRRL B-5473]) have been deposited with the United States Department of Agriculture, Agricultural Research Service, Northern Marketing and Nutrient Research Division, Peoria, Ill. The P. aeruginosa NRRL B-5472 was derived from Pseudomonas aeruginosa strain 1c by the genetic transfer thereto, and containment therein, of camphor, octane, salicylate and naphthalene degradative pathways in the form of plasmids. The P.
    Type: Grant
    Filed: June 7, 1972
    Date of Patent: March 31, 1981
    Assignee: General Electric Company
    Inventor: Ananda M. Chakrabarty