Patents by Inventor Anastasia Khvorova

Anastasia Khvorova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DYNAMIC PHARMACOKINETIC-MODIFYING ANCHORS
    Publication number: 20220372476
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Application
    Filed: April 20, 2022
    Publication date: November 24, 2022
    Inventors: Anastasia Khvorova, Bruno Miguel da Cruz Godinho, Matthew Hassler
  • Exosomal loading using hydrophobically modified oligonucleotides
    Patent number: 11505807
    Abstract: In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobically modified oligonucleotide cargo, and uses thereof, are also provided.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: November 22, 2022
    Assignee: University of Massachusetts
    Inventors: Anastasia Khvorova, Neil Aronin, Marie Cecile Didiot, Reka Haraszti
  • OLIGONUCLEOTIDE COMPOUNDS FOR TREATMENT OF PREECLAMPSIA AND OTHER ANGIOGENIC DISORDERS
    Publication number: 20220364100
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Application
    Filed: April 12, 2022
    Publication date: November 17, 2022
    Inventors: Anastasia Khvorova, Melissa Moore, Anton A. Turanov, Ananth Karumanchi
  • Dynamic pharmacokinetic-modifying anchors
    Patent number: 11492619
    Abstract: Therapeutic oligonucleotides comprising pharmacokinetic (PK)-modifying anchors are provided. Methods for treating diseases or disorders comprising administering to a subject a therapeutic oligonucleotide comprising one or more PK-modifying anchors are provided.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: November 8, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Bruno Miguel Da Cruz Godinho, Matthew Hassler
  • OLIGONUCLEOTIDES FOR SYNGR-3 MODULATION
    Publication number: 20220348918
    Abstract: This disclosure relates to novel SYNGR-3 targeting sequences. Novel SYNGR-3 targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: March 25, 2022
    Publication date: November 3, 2022
    Inventors: Anastasia Khvorova, Chantal Ferguson
  • TARGETING RLIM TO MODULATE BODY WEIGHT AND OBESITY
    Publication number: 20220340903
    Abstract: Methods for the treatment of weight-related disorders, including obesity and disorders associated with obesity, as well as underweight and disorders associated with underweight, by modulating Rlim levels.
    Type: Application
    Filed: September 25, 2020
    Publication date: October 27, 2022
    Inventors: Ingolf Bach, Feng Wang, Anastasia Khvorova, Chantal Ferguson
  • Methods and Compositions for Selecting siRNA of Improved Functionality
    Publication number: 20220315922
    Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
    Type: Application
    Filed: November 5, 2021
    Publication date: October 6, 2022
    Applicant: Thermo Fisher Scientific Inc.
    Inventors: Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
  • O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES
    Publication number: 20220251555
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Application
    Filed: January 20, 2022
    Publication date: August 11, 2022
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • OLIGONUCLEOTIDE COMPOUNDS FOR TARGETING HUNTINGTIN MRNA
    Publication number: 20220251554
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Application
    Filed: November 29, 2021
    Publication date: August 11, 2022
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • Neutral nanotransporters
    Patent number: 11396654
    Abstract: Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: July 26, 2022
    Assignee: Phio Pharmaceuticals Corp.
    Inventors: Anastasia Khvorova, William Salomon, Joanne Kamens, Dmitry Samarsky, Tod M. Woolf, Michelle Miller, Karen G. Bulock
  • OLIGONUCLEOTIDES FOR DGAT2 MODULATION
    Publication number: 20220228141
    Abstract: This disclosure relates to novel DGAT2 targeting sequences. Novel DGAT2 targeting oligonucleotides for the treatment of non-alcoholic fatty liver disease (NAFLD) and lipodystrophy syndromes (or metabolic syndrome) are also provided.
    Type: Application
    Filed: November 22, 2021
    Publication date: July 21, 2022
    Inventors: Michael P. Czech, Batuhan Orbay Yenilmez, Anastasia Khvorova
  • AIM2 INHIBITORS AND USES THEREOF
    Publication number: 20220175816
    Abstract: Described herein are AIM2 inhibitors (e.g., inhibitory nucleic acids), vectors, cells (e.g., dendritic cells), and compositions comprising same, and methods of using same in the treatment of cancer (e.g., melanoma).
    Type: Application
    Filed: April 16, 2020
    Publication date: June 9, 2022
    Inventors: Keitaro Fukuda, John E. Harris, Anastasia Khvorova, Kate Fitzgerald
  • Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders
    Patent number: 11345917
    Abstract: This disclosure relates to novel targets for angiogenic disorders. Novel oligonucleotides are also provided. Methods of using the novel oligonucleotides for the treatment of angiogenic disorders (e.g., preeclampsia) are also provided.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: May 31, 2022
    Assignees: UNIVERSITY OF MASSACHUSETTS, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Anastasia Khvorova, Melissa Moore, Anton A. Turanov, Ananth Karumanchi
  • OLIGONUCLEOTIDES FOR HTT-1A MODULATION
    Publication number: 20220090069
    Abstract: This disclosure relates to novel HTT-1A targeting sequences. Novel HTT-1A targeting oligonucleotides for the treatment of neurodegenerative diseases are also provided.
    Type: Application
    Filed: August 2, 2021
    Publication date: March 24, 2022
    Inventors: Anastasia Khvorova, Julia Alterman, Socheata Ly, Faith Conroy, Daniel O'Reilly
  • O-methyl rich fully stabilized oligonucleotides
    Patent number: 11279930
    Abstract: Novel oligonucleotides that are fully chemically stabilized are provided. Methods of using oligonucleotides that are fully chemically stabilized are also provided.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: March 22, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Julia Alterman, Sarah Davis, Anton Turanov
  • Inhibition of MAP4K4 through RNAi
    Patent number: 11254940
    Abstract: RNAi constructs directed to MAP4K4 that demonstrate unexpectedly high gene silencing activities, and uses thereof are disclosed. The blunt-ended constructs have a double-stranded region of 19-49 nucleotides. The constructs have selective minimal modifications to confer an optimal balance of biological activity, toxicity, stability, and target gene specificity. For example, the strands may be modified (e.g., one or both ends of the sense strand is modified by 2?-O-methyl groups), such that the construct is not cleaved by Dicer or other RNAse III, the antisense strand may also be modified by a 2?-O-methyl group at the penultimate 5?-end nucleotide to greatly reduce off-target silencing.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: February 22, 2022
    Assignee: Phio Pharmaceuticals Corp.
    Inventors: Tod M. Woolf, Joanne Kamens, Anastasia Khvorova, William Salomon
  • CONJUGATED OLIGONUCLEOTIDES FOR TISSUE SPECIFIC DELIVERY
    Publication number: 20220042015
    Abstract: Provided herein are conjugated oligonucleotides that are characterized by efficient and specific tissue distribution with enhanced in vivo silencing efficacy.
    Type: Application
    Filed: July 16, 2021
    Publication date: February 10, 2022
    Inventors: Anastasia Khvorova, Annabelle Biscans
  • Oligonucleotide compounds for targeting huntingtin mRNA
    Patent number: 11230713
    Abstract: This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of Huntington's disease are also provided.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: January 25, 2022
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Anastasia Khvorova, Neil Aronin, Julia Alterman
  • SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES WITH INCREASED STABILITY
    Publication number: 20220010309
    Abstract: This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.
    Type: Application
    Filed: March 26, 2021
    Publication date: January 13, 2022
    Inventors: Anastasia Khvorova, Loïc Maurice René Jean Roux, Ken Yamada
  • SYNTHETIC OLIGONUCLEOTIDES HAVING REGIONS OF BLOCK AND CLUSTER MODIFICATIONS
    Publication number: 20210395739
    Abstract: This disclosure relates to novel modified oligonucleotides with increased stability. The universal modified nucleotide sequences to increase the stability of an oligonucleotide are also provided.
    Type: Application
    Filed: May 26, 2021
    Publication date: December 23, 2021
    Inventors: Anastasia Khvorova, Loïc Maurice René Jean Roux, Ken Yamada