Patents by Inventor Andras Ballagi

Andras Ballagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for refolding G-CSF from inclusion bodies
    Patent number: 9458207
    Abstract: New methods for the refolding of recombinant granulocyte colony stimulating factor (G-CSF) from inclusion bodies are disclosed. The methods comprise two refolding steps. In particular, the methods comprise the solubilizing of G-CSF with a solubilizing agent, the oxidative refolding (first refolding step) of G-CSF in the presence of the solubilizing agent and an oxidizing agent, the efficient removal of the solubilizing agent, and a second refolding step to complete the folding of G-CSF in the absence of the solubilizing agent. Various methods are described for the efficient removal of the solubilizing agent from partially refolded G-CSF.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: October 4, 2016
    Assignee: Richter Gedeon Nyrt.
    Inventors: Ferenc Felföldi, Andras Ballagi, János Bécsi
  • METHODS FOR REFOLDING G-CSF FROM INCLUSION BODIES
    Publication number: 20150057439
    Abstract: New methods for the refolding of recombinant granulocyte colony stimulating factor (G-CSF) from inclusion bodies are disclosed. The methods comprise two refolding steps. In particular, the methods comprise the solubilising of G-CSF with a solubilising agent, the oxidative refolding (first refolding step) of G-CSF in the presence of the solubilising agent and an oxidizing agent, the efficient removal of the solubilising agent, and a second refolding step to complete the folding of G-CSF in the absence of the solubilising agent. Various methods are described for the efficient removal of the solubilising agent from partially refolded G-CSF.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 26, 2015
    Applicant: Richter Gedeon Nyrt.
    Inventors: Ferenc Felföldi, Andras Ballagi, János Bécsi