Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A cooling arrangement for air conditioning an IT environment and especially for climate control in a data processing center, in which a first heat exchanger packet and a least a first blower are incorporated, wherein the first blower is set up to draw air from the building or the data processing center over a first of two oppositely positioned housing sides, convey it through the housing and the first heat exchanger packet and blow it out of the housing over a second housing side located opposite the first housing side, and wherein outside of the building or data processing center a second heat exchanger packet is disposed and air is blown through it by at least one second blower.

Abstract: A cooling arrangement for air conditioning an IT environment and especially for climate control in a data processing center, in which a first heat exchanger packet and a least a first blower are incorporated, wherein the first blower is set up to draw air from the building or the data processing center over a first of two oppositely positioned housing sides, convey it through the housing and the first heat exchanger packet and blow it out of the housing over a second housing side located opposite the first housing side, and wherein outside of the building or data processing center a second heat exchanger packet is disposed and air is blown through it by at least one second blower.