Patents by Inventor Andrea Leone-Bay

Andrea Leone-Bay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11872265
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: January 16, 2024
    Assignee: MANNKIND CORPORATION
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Publication number: 20240000879
    Abstract: Herbal compositions in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The herbal composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: September 13, 2023
    Publication date: January 4, 2024
    Applicant: Spoke Sciences, Inc.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20230293479
    Abstract: Synthetic cannabinoid medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The synthetic cannabinoid composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: June 7, 2022
    Publication date: September 21, 2023
    Applicant: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20230075677
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: August 23, 2021
    Publication date: March 9, 2023
    Applicant: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20220362147
    Abstract: A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.
    Type: Application
    Filed: July 14, 2022
    Publication date: November 17, 2022
    Inventors: Peter Richardson, Robert A. Baughman, Andrea Leone-Bay, Donald Costello
  • Publication number: 20220133685
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: January 10, 2022
    Publication date: May 5, 2022
    Applicant: Receptor Holdings, Inc.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Patent number: 11246852
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: February 15, 2022
    Assignee: Receptor Holdings, Inc.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20210393575
    Abstract: The current disclosure provides use of N-acylated fatty amino acids to reduce absorption variability in cannabinoid-based compositions.
    Type: Application
    Filed: November 19, 2019
    Publication date: December 23, 2021
    Applicant: Receptor Holdings, Inc.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Patent number: 11129897
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: September 28, 2021
    Assignee: Receptor Holdings, Inc.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20210244667
    Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.
    Type: Application
    Filed: April 27, 2021
    Publication date: August 12, 2021
    Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay
  • Patent number: 11013691
    Abstract: Disclosed herein are heat-stable dry powders which include peptides or protein such as oxytocin for use as a pharmaceutical composition. The composition is highly stable at increased temperatures and relatively high humid environments, and are intended for storage at room temperature with an improved shelf-life. In particular, the dry powders are intended for inhalation, however, other routes of administration can be used when reconstituted in solution.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: May 25, 2021
    Assignee: MannKind Corporation
    Inventors: Karine Fabio, Joseph J. Guarneri, Kieran Curley, Marshall L. Grant, Andrea Leone-Bay
  • Publication number: 20210138041
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Application
    Filed: January 5, 2021
    Publication date: May 13, 2021
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Patent number: 10912821
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: February 9, 2021
    Assignee: MannKind Corporation
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Publication number: 20200405731
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: September 9, 2020
    Publication date: December 31, 2020
    Inventors: Joseph J. Guarneri, Marshall Grant, Chad C. Smutney, John J. Freeman, JR., Nikhil Amin, Kelly S. Kraft, Andrea Leone-Bay
  • Publication number: 20200268821
    Abstract: Herbal compositions in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The herbal composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: October 5, 2018
    Publication date: August 27, 2020
    Applicant: Receptor Holdings, Inc.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20200254041
    Abstract: Rapid onset and extended action plant-based medicinal compounds or nutritional supplements and synthetic cannabinoid formulations are described. Rapid onset is provided by N-acylated fatty amino acids and/or penetration enhancers. Extended action can be provided by one or more sustained-release systems.
    Type: Application
    Filed: October 5, 2018
    Publication date: August 13, 2020
    Applicant: Receptor Holdings, Inc.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20200197521
    Abstract: Plant-based medicinal compounds or nutritional supplements in various carrier combinations are described. The carriers can include N-acylated fatty amino acids, penetration enhancers, and/or various other beneficial carriers. The plant-based composition/carrier combinations can create administration benefits.
    Type: Application
    Filed: February 28, 2020
    Publication date: June 25, 2020
    Applicant: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner
  • Publication number: 20200164044
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Application
    Filed: January 27, 2020
    Publication date: May 28, 2020
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Publication number: 20200146981
    Abstract: A method of introducing a physiologically-active agent into the circulatory system of a mammal is disclosed herein. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent being administered to a patient in need of treatment. In particular, the drug delivery system is designed for pulmonary drug delivery such as by inhalation, for delivery of the active agents such as proteins and peptides to the pulmonary circulation in a therapeutically effective manner avoiding degradation of the active agents in peripheral and vascular tissue before reaching the target site.
    Type: Application
    Filed: January 13, 2020
    Publication date: May 14, 2020
    Inventors: Peter Richardson, Robert A. Baughman, Andrea Leone-Bay, Donald Costello
  • Publication number: 20200101034
    Abstract: Fast-acting oral formulations with restored entourage effects are described. The formulations include beneficial combinations of plant-derived molecules to provide restored entourage effects, and one or more carriers. The carriers can include N-acylated fatty amino acids, absorption enhancers, and/or various other beneficial carriers. The fast-acting oral formulations can create administration benefits.
    Type: Application
    Filed: March 23, 2018
    Publication date: April 2, 2020
    Applicant: RECEPTOR HOLDINGS, INC.
    Inventors: Andrea Leone-Bay, Gregory Wesner