Abstract: A compound of formula I having the structure: or a pharmaceutically acceptable salt thereof, wherein A1 and A2 are independently O or S; X is selected from CH2, CD2, NR3, O, and S, where R3 is selected from hydrogen, C1-C4 linear or branched chain alkyl, halo(C1-C4)linear or branched chain alkyl, and hydroxyl(C1-C4)linear or branched chain alkyl; Y and Z are selected from C and N, where when Y is C, then Z is N, and when Y is N, then Z is C; R1 and R2 are independently selected from hydrogen, deuterium, C1-C4 linear or branched chain alkyl, etc.; or a C1-C2 alkyl substituted with a C3-C5 cycloalkyl ring; or taken together to form a C3-C6 cycloalkyl ring; or where X is CH2 or CD2, then R1 and R2 are independently selected from hydrogen, deuterium, halogen, hydroxyl, C1-C4 linear or branched chain alkyl, etc.; R4 is selected from hydrogen, deuterium, cyano, halogen, (C1-C3) alkoxy, etc.; R5 is selected from hydrogen, deuterium, halogen, C1-C3 alkoxy, amino, (C1-C4 linear or branched chain alkyl)amino, etc.

Abstract: A method may be used for treating keratin material, such as human hair, where a cosmetic agent is applied to the keratin material. After an exposure time, the cosmetic agent is rinsed off. The cosmetic agent may include a mixture of organic C1-C6 alkoxy siloxanes, said mixture being obtained by specifically hydrolyzing and precondensing one or more organic C1-C6 alkoxy siloxanes by adding water and catalyst, and where the hydrolysis and precondensation is carried out in the absence of a solvent different from water.

Abstract: An agent for dyeing keratin material, such as human hair, may include at least two organosilicon compounds different from each other. Each organosilicon compound may be independently selected from silanes with one, two, or three silicon atoms, and the organosilicon compound may include one or more hydroxyl groups and/or hydrolyzable groups per molecule. The agent may include at least one pigment, and at least one fatty component that is liquid at 20° C. and/or an organic solvent. The agent may be used for dyeing keratin material.

Abstract: Techniques are disclosed for managing aspects of identifying and/or deploying hardware of a dedicated cloud to be hosted at a customer location (a “DRCC”). A DRCC may comprise cloud infrastructure components provided by a cloud provider but hosted by computing devices located at the customer's (a “cloud owner's”) location. Services of the central cloud-computing environment may be similarly executed at the DRCC. A number of user interfaces may be hosted within the central cloud-computing. These interfaces may be used to track deployment and region data of the DRCC. A deployment state may be transitioned from a first state to a second state based at least in part on the tracking and the deployment state may be presented at one or more user interfaces. Using the disclosed user interfaces, a user may manage the entire lifecycle of a DRCC and its corresponding hardware components.

Abstract: The invention is based on a patient recruitment system (10) having at least one patient recruitment server (16), which comprises at least one search routine (70) that is provided to search for patient data records (32) on the basis of recruitment characteristics (66). It is proposed that the patient recruitment server (16) comprises a notification routine (82) which is provided to send a recruitment notification (76) regarding at least one patient data record (32) found on the basis of the recruitment characteristics (66).

Abstract: The subject of the present application is a cosmetic composition for the treatment of keratinous material, in particular human hair, obtained by mixing a first agent (A) with a second agent (B), wherein the first agent (A) is obtained by reacting one or more organic C1-C6 alkoxysilanes with an amount of water equal to the molar amount of water determined according to equation (G-1), X=[(nI(Alkoxysilane)×nII(Alkoxy groups)]/n(H2O)??(G-1) Where the terms used in equation (G-1) are defined. the second agent (B) is obtained by reacting one or more organic C1-C6 alkoxysilanes with an amount of water equal to the molar amount of water determined according to equation (G-2), Y=[(na(Alkoxysilane)×nb(Alkoxy groups)]/m(H2O)??(G-2) Where the terms used in equation (G-2) are defined.

Abstract: A motorized medical suction pump has a pump assembly for generating an underpressure, a pump assembly carrier for supporting the pump assembly, and a seat for receiving an energy accumulator. The pump assembly arranged in the pump assembly carrier defines a first longitudinal axis, and the seat defines a second longitudinal axis. The pump assembly carrier forms the seat. The second longitudinal axis extends at an angle to the first longitudinal axis. This suction pump is small and compact and has good sound damping.

Abstract: The present disclosure relates to a fluid connection arrangement for establishing a fluid connection, including a receiving part having a receiving wall that has a receiving wall inner side that delimits an interior of the receiving part, a tubular connecting part that is at least partially received in the interior of the receiving part and has a tube wall having a plurality of comb-shaped support points that extend along a longitudinal direction of the tubular connecting part, the comb-shaped support points contacting the receiving wall inner side. The tube wall may have at least one curved wall area that extends between two adjacent comb-shaped support points. Between the at least one curved wall area of the tubular connecting part and the receiving wall inner side of the receiving part at least one gap is arranged where a solder is received to establish a materially bonded and fluid-tight connection.

Abstract: A glass forming machine and a method for manufacturing formed glass parisons. A glass forming machine includes a blank side for forming parisons from gobs of molten glass. The blank side includes a plunger and a blank mould. The plunger can be moved into the blank mould up to an end position. The plunger can be moved out of the blank mould up to a start position. The glass forming machine includes a glass feeding device which is configured to bring a gob of molten glass into the blank mould. The glass forming machine includes a measuring device which is configured to measure the end position of the plunger. The glass feeding device is configured such that the size of a gob of molten glass depends on the end position previously reached during operation. Parisons of good quality can be produced with a bigger tolerance of mould volumina.

Abstract: A pigment suspension, a cometic agent obtainable from a pigment suspension, and a kit-of-parts containing a pigment suspension are provided. A pigment suspension includes (a) at least one coloring compound selected from the group consisting of pigments, (b) at least one phosphoric ester, and (c) water.

Abstract: Single-photon detector apparatus comprising a large core optical fiber with a core diameter larger than 8 µm, a small core optical fiber with a core diameter smaller or equal to 5 µm, a taper between the large core optical fiber and the small core optical fiber, a superconducting nanowire having a surface area configured to receive all photons emitted from the small core optical fiber and cost effective and high yield method for manufacturing such.

Abstract: The subject of the present application is a process for the treatment of keratinous material, in particular human hair, wherein a cosmetic agent is applied to the keratinous material and rinsed off again after a contact time, exemplified in that the cosmetic agent contains a mixture of organic C1-C6 alkoxy siloxanes which is obtained by mixing one or more organic C1-C6 alkoxysilanes with a solvent other than water and selectively hydrolyzing and precondensing the mixture by adding water and catalyst.

Abstract: A method for determining an offset of an angular position encoder is associated with a rotor of an electric machine, wherein a reference offset of a reference angular position encoder of a reference electric machine is known at a reference rotational speed and a reference current with a reference phase angle and a reference absolute value. The method includes the steps of applying a current having the reference absolute value; setting a phase angle of the current to achieve the reference rotational speed; comparing the phase angle with the reference phase angle and the reference offset; and determining the offset on the basis of this comparison.

Abstract: A process for preparing a cosmetic composition useful for treating keratinous material, in particular human hair, is disclosed. The process comprises preparing a first agent (A) by reacting one or more aminoalkyl-C1-C6 alkoxysilanes (a1) with water (a2), preparing a second agent (B) by reacting one or more alkyl-C1-C6 alkoxysilanes (b1) with water (b2), and mixing together the first agent (A) and the second agent (B), thereby preparing the cosmetic composition. A cosmetic composition prepared by the process, as well as a method of using the cosmetic composition for treating keratinous material (e.g. coloring human hair) are also disclosed.

Abstract: A patient recruitment system, in particular for clinical studies, has at least one database environment comprising at least one database module that is configured at least to store in a patient database at least patient data records containing at least one course of treatment of at least one patient, has at least one patient recruitment server comprising at least one patient recruitment module that is configured to search and at least compare with at least one recruitment feature, data records, in particular courses of treatment, and has a data transport unit for a data transfer, in particular of at least one course of treatment, between the database environment and the patient recruitment server, the data transport unit comprises a restriction module, which restricts the data transfer to outbound connections originating from the database environment.

Abstract: A method determines a correction value for a control device for an electric machine, which describes an angular difference between a position of a d-axis of the electric machine and an actual position of the d-axis. The correction value is determined in a rotating state of a rotor of the electric machine as a function of a d voltage value describing a d component of a stator voltage specified by the control device in the initial configuration, of a q voltage value describing a q component of the stator voltage specified by the control device in the initial configuration, of a flux value describing a magnetic flux of the rotor, a speed value describing the speed of the rotor in the rotating state, and of a calibration value describing a speed-dependent voltage error of the d component of the stator voltage.

Abstract: The present invention relates to a motor-driven medical suction pump with a pump unit for generating a negative pressure with a housing which accommodates the pump unit therein, wherein the pump unit comprises a vacuum opening for the negative pressure to be generated by the pump unit and at least one further opening communicating with the vacuum opening through the pump unit. The present invention indicates a suction pump of the type mentioned above which is easy to produce, compact in design and provided with good sound damping properties and which for this purpose comprises a sound damping chamber which is tightly connected to and encloses the further opening.

Abstract: The subject of the present disclosure is a process for the preparation and storage of an agent for the treatment of keratinous material, in particular human hair, comprising the following steps: (1) mixing one or more organic C1-C6 alkoxy silanes with water, (2) optionally, partial, or complete removal from the reaction mixture of the C1-C6 alcohols liberated by the reaction in step (1), (3) if necessary, addition of one or more cosmetic ingredients, (4) filling of the preparation into a packaging unit, and (5) storage of the preparation in the packaging unit, wherein at least one of steps (1), (2), (3), (4) and/or (5) is carried out under an atmosphere having a water vapor content of less than about 10 g/m3.

Abstract: The subject of the present application is a process for the preparation of an agent for the treatment of keratinous material, in particular human hair, comprising the following steps: (1) reaction of one or more organic C1-C6 alkoxy silanes with water at a temperature of from about 20 to about 70° C. to give a reaction mixture, (2) complete or partial removal of C1-C6 alcohols released by a reaction in step (1) from the reaction mixture at a temperature of from about 20 to about 70° C., (3) optionally, addition of one or more cosmetic ingredients to the reaction mixture, thereby giving a preparation, and (4) filling the preparation into a packaging unit.

Abstract: The present disclosure relates to a fluid connection arrangement for establishing a fluid connection, including a receiving part having a receiving wall that has a receiving wall inner side that delimits an interior of the receiving part, a tubular connecting part that is at least partially received in the interior of the receiving part and has a tube wall having a plurality of comb-shaped support points that extend along a longitudinal direction of the tubular connecting part, the comb-shaped support points contacting the receiving wall inner side. The tube wall may have at least one curved wall area that extends between two adjacent comb-shaped support points. Between the at least one curved wall area of the tubular connecting part and the receiving wall inner side of the receiving part at least one gap is arranged where a solder is received to establish a materially bonded and fluid-tight connection.