Abstract: The invention relates to biologically active molecules, which interact with and inhibit thrombin. The invention particularly relates to molecules of general formula (I): Y1—(NH—X1—CO)—(NH—X2—C?O)—(NH—X3—C?O)—(NH—X.sup.4—C?O)—(NH—X6—C?O) (NH—X6—C?O)—Y2, wherein the compound can be used for thrombin inhibition, inhibition of fibrin formation, and/or for the inhibition of the formation of a clot. Compounds disclosed herein can also be used for treatingm, diagnosing, and prophylaxis of thrombotic disorders.

Abstract: The invention relates to the use of substances which bind to the bacterial elongation factor EF-Tru for cell digestion or for the lysis of cells. The invention further relates to a cell digestion system and a cell digestion method.

Abstract: The invention relates to biologically active molecules, which interact with thrombin and inhibit the same. The invention particularly relates to molecules of general fomula (I): Y1—(NH—X1—C?O)—(NH—X2—C?O)—(NH—X3—C?O)—(NH—X4—C?O)—(NH—X6—C?O) (NH—X6—C?O)—Y2, wherein Y1, Y2 and X1-6 have the meanings given in the description and N- or C-terminal abbreviated variations of said compounds and the use thereof for the production of medicaments.

Abstract: A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system, a) whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and, whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus, b) and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.

Abstract: A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system,

Abstract: A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system, a) whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and, whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus, b) and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.