Patents by Inventor Andrei V. Gudkov

Andrei V. Gudkov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing the effects of chemotherapy using flagellin related polypeptides
    Patent number: 8580321
    Abstract: The use of flagellin and flagellin related polypeptides for reducing cancer treatment side effects in mammals is described.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: November 12, 2013
    Assignee: The Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Vadim Krivokrysenko, Lyudmila Burdelya
  • METHODS FOR TREATING REPERFUSION INJURIES
    Publication number: 20130004515
    Abstract: The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin
    Type: Application
    Filed: June 22, 2012
    Publication date: January 3, 2013
    Applicants: CLEVELAND CLINIC FOUNDATION, CLEVELAND BIOLABS, INC.
    Inventors: Andrei V. Gudkov, Robert Fairchild
  • Method and Compositions for Suppression of Aging
    Publication number: 20120283269
    Abstract: The present invention provides a method of suppression and/or deceleration of mammalian cellular aging. The method involves contacting mammalian cells with a composition that contains a non-genotoxic inducer of p53 (NGIP). In certain embodiments, the NCIP is a Mdm-binding agent or Mdm-2 antagonist. The NGIP can be nutlin, nutlin-3A, a nutlin analog, or a combination thereof. The invention also provides a method for reducing cellular hypertrophy in an organism by administering a composition that contains an anti-hypertrophic compound, such as nutlin, nutlin-3A, a nutlin analog, rapamycin or a rapamycin analog and combinations thereof, to the organism.
    Type: Application
    Filed: November 4, 2010
    Publication date: November 8, 2012
    Applicant: HEALTH RESEARCH INC.
    Inventors: Mikhail V. Blagosklonny, Andrei V. Gudkov, Zoya N. Demidenko
  • Flagellin related polypeptides and uses thereof
    Patent number: 8287882
    Abstract: The use of flagellin and flagellin related polypectides for the protection of mammals from the effects of apoptsis is described.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: October 16, 2012
    Assignee: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • USE OF TOLL-LIKE RECEPTOR AND AGONIST FOR TREATING CANCER
    Publication number: 20120208871
    Abstract: The present invention is directed to methods and agents used for treating cancer or infectious diseases by providing toll-like receptors such as toll-like receptor 5 (TLR-5) in combination with providing a toll-like receptor agonists such as flagellin resulting in a cis and intrans effect that recruits cells involved in both the innate (cis effect) and adaptive (trans effect) immune response to specifically kill cancer cells and cells infected with a pathogen via the NF-?B apoptosis pathway.
    Type: Application
    Filed: October 6, 2010
    Publication date: August 16, 2012
    Inventor: Andrei V. Gudkov
  • Methods for identifying modulators of apoptosis
    Patent number: 8242057
    Abstract: Provided herein is a method for screening a modulator of apoptosis by contacting a cell comprising a FAS mediated apoptosis system, major vault protein and cytochrome b, with a candidate modulator, and measuring the level of apoptosis of the cell. The modulator of apoptosis is identified by a change in apoptosis in comparison to a control.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: August 14, 2012
    Assignee: Cleveland Biolabs, Inc.
    Inventor: Andrei V. Gudkov
  • Modulating apoptosis
    Patent number: 8106005
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: January 31, 2012
    Assignee: Cleveland Clinic Foundation
    Inventor: Andrei V. Gudkov
  • FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF
    Publication number: 20110319595
    Abstract: The use of flagellin and flagellin related polypectides for the protection of mammals from the effects of apoptsis is described.
    Type: Application
    Filed: May 18, 2011
    Publication date: December 29, 2011
    Applicant: CLEVELAND CLINIC FOUNDATION
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF
    Publication number: 20110319344
    Abstract: The use of flagellin and flagellin related polypectides for the protection of mammals from the effects of apoptsis is described.
    Type: Application
    Filed: May 18, 2011
    Publication date: December 29, 2011
    Applicant: CLEVELAND CLINIC FOUNDATION
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • Flagellin related polypeptides and uses thereof
    Patent number: 8007812
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 30, 2011
    Assignee: Cleveland Clinic Foundation
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • Modulating apoptosis
    Publication number: 20100120687
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Application
    Filed: November 12, 2009
    Publication date: May 13, 2010
    Inventor: Andrei V. Gudkov
  • MODULATION OF IMMUNE RESPONSES
    Publication number: 20100112012
    Abstract: Compositions and methods for modulating an NF-?B-mediated immune response are provided.
    Type: Application
    Filed: November 14, 2006
    Publication date: May 6, 2010
    Applicant: CLEVELAND CLINIC FOUNDATION
    Inventors: Andrei V. Gudkov, Robert Fairchild, Katerina Gurova
  • Method for Screening Modulators of Apoptosis
    Publication number: 20100056454
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Application
    Filed: November 12, 2009
    Publication date: March 4, 2010
    Inventor: Andrei V. Gudkov
  • Modulating apoptosis
    Patent number: 7638485
    Abstract: The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of NF-?B activity. The modulators may be used, for example, in the treatment of NF-?B-mediated diseases, conditions, and injuries.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: December 29, 2009
    Assignees: Cleveland Biolabs, Inc., Cleveland Clinic Foundation
    Inventor: Andrei V. Gudkov
  • Method for Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides
    Publication number: 20090246303
    Abstract: The use of flagellin and flagellin related polypeptides for reducing cancer treatment side effects in mammals is described.
    Type: Application
    Filed: February 11, 2009
    Publication date: October 1, 2009
    Inventors: Andrei V. Gudkov, Vadim Krivokrysenko, Lyudmila Burdelya
  • INHIBITION OF NF-KB
    Publication number: 20090099191
    Abstract: The present invention is generally related to the modulation of cell growth or apoptosis. Compositions for modulating cell growth or apoptosis, methods of use thereof, and methods of identification thereof are described.
    Type: Application
    Filed: February 2, 2007
    Publication date: April 16, 2009
    Inventor: Andrei V. Gudkov
  • Flagellin Related Polypeptides and Uses Thereof
    Publication number: 20090011982
    Abstract: The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.
    Type: Application
    Filed: December 22, 2005
    Publication date: January 8, 2009
    Inventors: Andrei V. Gudkov, Joseph A. DiDonato, Vadim Krivokrysenko
  • p53 Inhibitors and Therapeutic Use of the Same
    Publication number: 20080161426
    Abstract: The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
    Type: Application
    Filed: January 30, 2008
    Publication date: July 3, 2008
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Andrei V. Gudkov, Pavel G. Komarov, Elena A. Komarova
  • p53 inhibitors and therapeutic use of the same
    Patent number: 7012087
    Abstract: The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: March 14, 2006
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Andrei V. Gudkov, Pavel G. Komarov, Elena A. Komarova
  • p53 inhibitors and therapeutic use of the same
    Patent number: 7008956
    Abstract: The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
    Type: Grant
    Filed: January 28, 2003
    Date of Patent: March 7, 2006
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Andrei V. Gudkov, Pavel G. Komarov, Elena A. Komarova