Patents by Inventor Andres M. Lozano
Andres M. Lozano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230218901Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.Type: ApplicationFiled: November 17, 2022Publication date: July 13, 2023Applicant: Functional Neuromodulation, Inc.Inventor: Andres M. Lozano
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Publication number: 20230173257Abstract: Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.Type: ApplicationFiled: July 12, 2022Publication date: June 8, 2023Applicant: Functional Neuromodulation, Inc.Inventors: Andres M. Lozano, Hiroki Toda
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Patent number: 11395920Abstract: A system and method for identifying a patient-specific neurosurgery target location is provided. The system receives brain imaging data for a patient that includes tracts and networks in the patient brain, accesses a quantitative connectome atlas comprising population-based, disease-specific structural and functional connectivity maps comprising a pattern of tracts and networks associated with an optimal target area (OTA) identified from a population of patients, and defines the patient-specific neurosurgery target location based on a comparison between a pattern of the tracts and networks from the brain imaging data for the patient and the pattern of tracts and networks associated with the OTA identified from the population of patients in the quantitative connectome atlas.Type: GrantFiled: January 22, 2019Date of Patent: July 26, 2022Assignees: General Electric Company, University Health NetworkInventors: Radhika Madhavan, Gavin Elias, Alexandre Boutet, Suresh Joel, Andres M. Lozano
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Publication number: 20210275815Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.Type: ApplicationFiled: October 14, 2020Publication date: September 9, 2021Applicant: Functional Neuromodulation, Inc.Inventor: Andres M. Lozano
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Patent number: 10905882Abstract: A system and method for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system, the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system, and a DBS functional atlas is accessed, via the predictor system, that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system.Type: GrantFiled: January 22, 2019Date of Patent: February 2, 2021Assignees: General Electric Company, University Health NetworkInventors: Radhika Madhavan, Alexandre Boutet, Suresh Joel, Ileana Hancu, Jeffrey Ashe, Andres M. Lozano
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Publication number: 20200246611Abstract: Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.Type: ApplicationFiled: August 19, 2019Publication date: August 6, 2020Applicant: Functional Neuromodulation Inc.Inventors: Andres M. Lozano, Hiroki Toda
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Publication number: 20200230419Abstract: A system and method for optimizing parameters of a DBS pulse signal for treatment of a patient is provided. In predicting optimal DBS parameters, functional brain data is input into a predictor system, the functional brain data acquired responsive to a sweeping across a multi-dimensional parameter space of one or more DBS parameters. Statistical metrics of brain response are extracted from the functional brain data for one or more ROIs or voxels of the brain via the predictor system, and a DBS functional atlas is accessed, via the predictor system, that comprises disease-specific brain response maps derived from DBS treatment at optimal DBS parameter settings for a plurality of diseases or neurological conditions. One or more optimal DBS parameters are predicted for the patient based on the statistical metrics of brain response and the DBS functional atlas via the predictor system.Type: ApplicationFiled: January 22, 2019Publication date: July 23, 2020Inventors: Radhika Madhavan, Alexandre Boutet, Suresh Joel, Ileana Hancu, Jeffrey Ashe, Andres M. Lozano
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Patent number: 10384053Abstract: Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.Type: GrantFiled: November 15, 2013Date of Patent: August 20, 2019Assignee: Functional Neuromodulation Inc.Inventors: Andres M. Lozano, Hiroki Toda
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Publication number: 20190126044Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.Type: ApplicationFiled: April 30, 2018Publication date: May 2, 2019Applicant: Functional Neuromodulation, Inc.Inventor: Andres M. Lozano
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Patent number: 9931500Abstract: The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat an affective disorder, such as depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.Type: GrantFiled: March 1, 2006Date of Patent: April 3, 2018Inventors: Andres M. Lozano, Helen S. Mayberg
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Publication number: 20180071519Abstract: Methods and apparatus for inducing neurogenesis within a human. The invention utilizes an implantable signal generator to deliver high frequency stimulation to deep brain tissue elements. The implanted device delivers treatment therapy to the brain to thereby induce neurogenesis by the human. A sensor may be used to detect various symptoms of nervous system discovery. A microprocessor algorithm may then analyze the output from the sensor to regulate the stimulation and/or drug therapy delivered to the brain.Type: ApplicationFiled: November 15, 2013Publication date: March 15, 2018Applicant: Functional Neuromodulation Inc.Inventors: Andres M. Lozano, Hiroki Toda
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Publication number: 20170368354Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a Papez circuit of the human brain as well as tissue upstream or downstream from the Papez circuit. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various symptoms of the cognitive disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation and/or drug therapy.Type: ApplicationFiled: January 6, 2017Publication date: December 28, 2017Applicant: Functional Neuromodulation Inc.Inventor: Andres M. Lozano
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Patent number: 9669216Abstract: Disclosed are methods for regulating neurotrophin levels within a human body. The invention utilizes an implantable signal generator to deliver stimulation to neural tissue elements. Alternatively, an implantable pump may be utilized to delivery one or more drugs. The implanted device delivers treatment therapy to the neural tissue to thereby alter the level of neurotrophic factors such as BDNF expressed by the influenced neural tissue. A sensor may be used to detect various symptoms of a nervous system disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate the treatment therapy delivered to the body. The invention describes a novel method to regulate the intrinsic levels of neurotrophins and may be used to treat patients with neurological and cognitive disorders.Type: GrantFiled: December 21, 2015Date of Patent: June 6, 2017Assignee: Functional Neuromodulation Inc.Inventor: Andres M. Lozano
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Publication number: 20160331970Abstract: Techniques are provided for regulating the expression and clearance of proteins in neural tissue using electrical stimulation. The techniques may be used for treating and/or preventing neurodegenerative disorders such as Alzheimer's disease. The treatment involves implanting an electrode within the neural tissue of a human or animal subject, and using the electrode to deliver an electric current to the neural tissue. The voltage, pulse width, frequency, duration, and other parameters of the electrical stimulation may be controlled to provide different effects on protein expression and/or clearance. The position of the electrode may also be selected to control protein expression and/or clearance in a selected neural region.Type: ApplicationFiled: May 11, 2015Publication date: November 17, 2016Inventor: Andres M. Lozano
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Patent number: 9474852Abstract: The present application involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.Type: GrantFiled: May 4, 2015Date of Patent: October 25, 2016Assignee: Advanced Neuromodulation Systems, Inc.Inventors: Andres M. Lozano, Helen S. Mayberg
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Publication number: 20160279420Abstract: Disclosed are methods for regulating neurotrophin levels within a human body. The invention utilizes an implantable signal generator to deliver stimulation to neural tissue elements. Alternatively, an implantable pump may be utilized to delivery one or more drugs. The implanted device delivers treatment therapy to the neural tissue to thereby alter the level of neurotrophic factors such as BDNF expressed by the influenced neural tissue. A sensor may be used to detect various symptoms of a nervous system disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate the treatment therapy delivered to the body. The invention describes a novel method to regulate the intrinsic levels of neurotrophins and may be used to treat patients with neurological and cognitive disorders.Type: ApplicationFiled: December 21, 2015Publication date: September 29, 2016Inventor: Andres M. Lozano
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Patent number: 9446238Abstract: In one embodiment, a method of treating an eating disorder in a patient, comprises: diagnosing the eating disorder in the patient; and electrically stimulating a subgenual cingulate cortex site or a ventral medial prefrontal cortex site in the patient using electrodes of an implanted stimulation lead.Type: GrantFiled: January 24, 2014Date of Patent: September 20, 2016Inventor: Andres M. Lozano
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Patent number: 9358393Abstract: Methods of treating auditory hallucinations, hyperacusis, schizophrenia, and/or phonophobia include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters. The stimulation site may include, for example, at least one or more of a cochlear nucleus, auditory striae, superior olivary complex, lateral lemniscus, inferior colliculus, brachium of the inferior colliculus, medial geniculate body, primary auditory cortex, secondary auditory cortical area, and auditory radiation. Systems for treating auditory hallucinations, hyperacusis, schizophrenia, and/or phonophobia include an implanted stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters.Type: GrantFiled: November 9, 2005Date of Patent: June 7, 2016Inventor: Andres M. Lozano
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Publication number: 20160030666Abstract: The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat a cognitive impairment and/or disorder. More particularly, the method comprises surgically implanting an electrode and/or catheter that is in communication with a predetermined site which is coupled to a pulse generating source and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the cognitive disorder and/or enhancing the cognitive ability.Type: ApplicationFiled: December 30, 2014Publication date: February 4, 2016Applicant: Functional Neuromodulation, Inc.Inventors: Andres M. Lozano, Helen S. Mayberg
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Patent number: 9227066Abstract: Disclosed are methods for regulating neurotrophin levels within a human body. The invention utilizes an implantable signal generator to deliver stimulation to neural tissue elements. Alternatively, an implantable pump may be utilized to delivery one or more drugs. The implanted device delivers treatment therapy to the neural tissue to thereby alter the level of neurotrophic factors such as BDNF expressed by the influenced neural tissue. A sensor may be used to detect various symptoms of a nervous system disorder. A microprocessor algorithm may then analyze the output from the sensor to regulate the treatment therapy delivered to the body. The invention describes a novel method to regulate the intrinsic levels of neurotrophins and may be used to treat patients with neurological and cognitive disorders.Type: GrantFiled: October 7, 2014Date of Patent: January 5, 2016Assignee: FUNCTIONAL NEUROMODULATION INC.Inventor: Andres M. Lozano