Patents by Inventor Andrew A. Welcher

Andrew A. Welcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human anti-IFN-? neutralizing antibodies as selective IFN-? pathway inhibitors
    Patent number: 7335743
    Abstract: This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-?) and methods for treating IFN-? mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-?. Methods of detecting the amount of IFN-? in a sample using antibodies to IFN-? are also provided.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: February 26, 2008
    Assignee: Amgen Inc.
    Inventors: Andrew A. Welcher, Hilary T. Chute, Yue-Sheng “Luke” Li, Haichun Huang
  • C3b/C4b complement receptor-like molecules and uses thereof
    Publication number: 20060287502
    Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
    Type: Application
    Filed: May 5, 2006
    Publication date: December 21, 2006
    Applicant: AMGEN INC.
    Inventors: Andrew Welcher, Gary Elliott
  • EPH-like receptor protein tyrosine kinases
    Publication number: 20060216287
    Abstract: Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also disclosed.
    Type: Application
    Filed: August 9, 2005
    Publication date: September 28, 2006
    Inventors: Gary Fox, Andrew Welcher, Shuqian Jing
  • B7-like molecules and uses thereof
    Publication number: 20060168672
    Abstract: Novel B7-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing B7-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with B7-like polypeptides.
    Type: Application
    Filed: September 30, 2005
    Publication date: July 27, 2006
    Inventors: Andrew Welcher, Ulla Sarmiento, Henry Schultz, Hilary Chute
  • C3b/C4b Complement Receptor-like molecules and uses thereof
    Patent number: 7041796
    Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: May 9, 2006
    Assignee: Amgen Inc.
    Inventors: Andrew A. Welcher, Gary S. Elliott
  • C3b/C4b complement receptor-like molecules and uses thereof
    Publication number: 20060030005
    Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
    Type: Application
    Filed: September 26, 2005
    Publication date: February 9, 2006
    Applicant: Amgen Inc.
    Inventors: Andrew Welcher, Gary Elliott
  • TNFr/OPG-like molecules and uses thereof
    Publication number: 20060024267
    Abstract: The present invention provides novel TNFr/OPG-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies, and methods for producing TNFr/OPG-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases with TNFr/OPG-like polypeptides.
    Type: Application
    Filed: January 25, 2005
    Publication date: February 2, 2006
    Inventors: Andrew Welcher, Gary Fox, Michael Boedigheimer, Junyan Shu, Shuqian Jing, Brian Bennett, Roland Luethy
  • Interferon-Like molecules and uses thereof
    Publication number: 20060024795
    Abstract: The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.
    Type: Application
    Filed: August 8, 2005
    Publication date: February 2, 2006
    Inventors: Andrew Welcher, Duanzhi Wen, Michael Kelley
  • Nucleic acids encoding Eph-like receptor tyrosine kinases
    Patent number: 6992175
    Abstract: Four novel members of the EPH sub-family of receptor protein tyrosine kinases are disclosed. Nucleic acid sequences encoding receptor proteins, recombinant plasmids and host cells for expression, and methods of producing and using such receptors are also disclosed.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: January 31, 2006
    Assignee: Amgen Inc.
    Inventors: Gary M. Fox, Andrew A. Welcher, Shuqian Jing
  • Interferon-Like molecules and uses thereof
    Publication number: 20050221344
    Abstract: The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.
    Type: Application
    Filed: October 29, 2004
    Publication date: October 6, 2005
    Inventors: Andrew Welcher, Duanzhi Wen, Michael Kelley
  • Human anti-IFN-gamma neutralizing antibodies as selective IFN-gamma pathway inhibitors
    Publication number: 20050004353
    Abstract: This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-?) and methods for treating IFN-? mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-?. Methods of detecting the amount of IFN-? in a sample using antibodies to IFN-? are also provided.
    Type: Application
    Filed: October 14, 2003
    Publication date: January 6, 2005
    Inventors: Andrew Welcher, Hilary Chute, Yue-Sheng "Luke" Li, Haichun Huang
  • Nucleic encoding interleukin-1 receptor antagonist-like proteins and uses thereof
    Publication number: 20040208872
    Abstract: The present invention provides novel Interleukin-1 Receptor Antagonist-Like (IL-1ra-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IL-1ra-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IL-1ra-L polypeptides.
    Type: Application
    Filed: December 12, 2003
    Publication date: October 21, 2004
    Applicant: Amgen, Inc., A Corporation of the State of Delaware
    Inventors: Andrew A. Welcher, Roland Luethy, Shuqian Jing
  • C3b/C4b complement receptor-like molecules and uses thereof
    Patent number: 6656707
    Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
    Type: Grant
    Filed: July 24, 2001
    Date of Patent: December 2, 2003
    Assignee: Amgen Inc.
    Inventors: Andrew A. Welcher, Gary S. Elliott
  • Interleukin-1 receptor antagonist-like molecules and uses thereof
    Publication number: 20030166069
    Abstract: The present invention provides novel Interleukin-1 Receptor Antagonist-Like (IL-1ra-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IL-1ra-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IL-1ra-L polypeptides.
    Type: Application
    Filed: May 6, 2002
    Publication date: September 4, 2003
    Applicant: Amgen, Inc.
    Inventors: Andrew A. Welcher, Roland Luethy, Shuqian Jing
  • TNFr/OPG-like molecules and uses thereof
    Publication number: 20030077246
    Abstract: The present invention provides novel TNFr/OPG-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies, and methods for producing TNFr/OPG-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases with TNFr/OPG-like polypeptides.
    Type: Application
    Filed: May 15, 2002
    Publication date: April 24, 2003
    Inventors: Andrew A. Welcher, Gary M. Fox, Michael J. Boedigheimer, Junyan Shu, Shuqian Jing, Brian D. Bennett, Roland Luethy
  • C3b/C4b complement receptor-like molecules and uses thereof
    Publication number: 20020192758
    Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
    Type: Application
    Filed: May 16, 2002
    Publication date: December 19, 2002
    Inventors: Andrew A. Welcher, Gary S. Elliott
  • Eck receptor ligands
    Patent number: 6479250
    Abstract: Ligands which bind to the eck receptor are disclosed. More particularly, polypeptides which bind specifically to the eck receptor (eck receptor binding proteins or EBPs) and DNA sequences encoding said polypeptides are disclosed. Methods of treatment using eck receptor ligands and soluble eck receptor and disclosed, as are pharmaceutical compositions containing same. A rapid and sensitive method for the detection of receptor binding activity in crude samples is provided.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: November 12, 2002
    Assignee: Amgen Inc.
    Inventors: Timothy D. Bartley, William J. Boyle, Gary M. Fox, Andrew A. Welcher, Ella Magal, Richard A. Lindberg, Vann P. Parker
  • C3b/C4b complement receptor-like molecules and uses thereof
    Publication number: 20020151483
    Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.
    Type: Application
    Filed: July 24, 2001
    Publication date: October 17, 2002
    Inventors: Andrew A. Welcher, Gary S. Elliott
  • Interferon-like molecules and uses thereof
    Publication number: 20020137137
    Abstract: The present invention provides Interferon-Like (IFN-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing IFN-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with IFN-L polypeptides.
    Type: Application
    Filed: August 10, 2001
    Publication date: September 26, 2002
    Applicant: Amgen, Inc.
    Inventors: Andrew Welcher, Duanzhi Wen, Michael Kelley
  • CD20/IgE-receptor like molecules and uses thereof
    Publication number: 20020064823
    Abstract: Novel CD20/IgE-receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing CD20/IgE-receptor like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with CD20/IgE-receptor like polypeptides.
    Type: Application
    Filed: March 29, 2001
    Publication date: May 30, 2002
    Inventors: Andrew A. Welcher, Frank J. Calzone