Patents by Inventor Andrew B. Adams

Andrew B. Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190345534
    Abstract: An activity-based nanosensor composition for detecting protease activity comprising a cleavable detectable substrate and methods of use are disclosed.
    Type: Application
    Filed: September 28, 2017
    Publication date: November 14, 2019
    Inventors: Gabriel A. Kwong, Andrew B. Adams, Quoc Mac, David V. Mathews
  • Publication number: 20190194166
    Abstract: The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: June 13, 2017
    Publication date: June 27, 2019
    Inventors: Nicholas David ADAMS, Andrew B. BENOWITZ, MarĂ­a Lourdes Rueda BENEDE, Karen Anderson EVANS, David T. FOSBENNER, Bryan Wayne KING, Mei LI, Juan Ignacio LUENGO, William Henry MILLER, Alexander Joseph REIF, Stuart Paul ROMERIL, Stanley J. SCHMIDT, Roger J. BUTLIN, Kristen M. GOLDBERG, Allan M. JORDAN, Christopher S. KERSHAW, Ali RAOOF, Bohdan WASZKOWYCS
  • Patent number: 7829534
    Abstract: The present invention is a method of inhibiting islet cell transplant rejection particular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 mutant molecule is L104EA29YIg.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: November 9, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Christian P. Larsen, Thomas C. Pearson, Andrew B. Adams, Robert J. Peach, Peter S. Linsley, Joseph Roy Naemura, Jurgen Bajorath
  • Publication number: 20080160022
    Abstract: The present invention is a method of inhibiting islet cell transplant rejection particular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 mutant molecule is L104EA29YIg.
    Type: Application
    Filed: October 29, 2007
    Publication date: July 3, 2008
    Applicant: Bristol-Myers Squibb Company
    Inventors: Christian P. Larsen, Thomas C. Pearson, Andrew B. Adams, Robert J. Peach, Peter S. Linsley, Joseph Roy Naemura, Jurgen Bajorath
  • Patent number: 7304033
    Abstract: The present invention is a method of inhibiting islet cell transplant rejection, particularly to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of a soluble CTLA4 mutant molecule is L104EA29YIg.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: December 4, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Christian P. Larsen, Thomas C. Pearson, Andrew B. Adams, Robert J. Peach, Peter S. Linsley, Joseph Roy Naemura, Jurgen Bajorath
  • Publication number: 20030022836
    Abstract: The present invention is a method of inhibiting islet cell transplant rejection particular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 mutant molecule is L104EA29YIg.
    Type: Application
    Filed: May 23, 2002
    Publication date: January 30, 2003
    Inventors: Christian P. Larsen, Thomas C. Pearson, Andrew B. Adams
  • Publication number: 20030007968
    Abstract: Methods of establishing hematopoietic chimerism useful to correct hematological diseases and promote acceptance of organ transplants include administering busulfan, costimulation blockade, and readily attainable numbers of T-cell depleted bone marrow cells.
    Type: Application
    Filed: January 25, 2002
    Publication date: January 9, 2003
    Inventors: Christian P. Larsen, Thomas C. Pearson, Edmund K. Waller, Andrew B. Adams
  • Patent number: 4235145
    Abstract: A neck for a stringed instrument which is adjustable to counteract warping by tensioning a strap of substantially inextensible material positioned within the neck. In one embodiment, the strap is positioned inside a conduit inside the neck which can be bowed to counteract the warping. The strap is positioned in the conduit in the shape of an arc with the ends of the strap closer to the finger board or the strings than the central region of the strap by a plurality of rod members fixedly secured to the conduit. One end of the strap is fixedly secured to one end of the conduit and the other end can be moved to tension the strap and bow the conduit and neck to counteract warping. In another embodiment, the strap is shaped as an arc inside the conduit by an elongated filler element having an arcuate bottom surface which progressively increases in depth from the ends of the filler element toward the central region of it.
    Type: Grant
    Filed: February 8, 1979
    Date of Patent: November 25, 1980
    Inventor: Andrew B. Adams, Jr.
  • Patent number: 4167133
    Abstract: A neck for a stringed instrument which is adjustable to counteract warping by tensioning a strap of substantially inextensible material positioned within the neck. In one embodiment, the strap is positioned inside a conduit inside the neck which can be bowed to counteract the warping. The strap is positioned in the conduit in the shape of an arc with the ends of the strap closer to the finger board or the strings than the central region of the strap by a plurality of rod members fixedly secured to the conduit. One end of the strap is fixedly secured to one end of the conduit and the other end can be moved to tension the strap and bow the conduit and neck to counteract warping. In another embodiment, the strap is shaped as an arc inside the conduit by an elongated filler element having an arcuate bottom surface which progressively increases in depth from the ends of the filler element toward the central region of it.
    Type: Grant
    Filed: June 16, 1978
    Date of Patent: September 11, 1979
    Assignee: Andrew Borden Adams, Jr.
    Inventor: Andrew B. Adams, Jr.