Abstract: An instrument (200) for positioning a hollow cup component (202) of an orthopedic joint prosthesis and assembly thereof are described. The instrument includes a support member (204) having a plurality of jaw members (208) unitarily formed around its periphery. Each of the jaw members has a cup engaging limb (210) extending in a first direction to be received in a recess on an external side wall of the cup component. Each jaw member is pivotable between an engaged position in which the cup engaging limbs are displaced inwardly and a disengaged position in which the cup engaging limbs are displaced outwardly allowing the cup component to be removed from between the jaw members.

Abstract: A cutting block comprises a body having a top surface for guiding a saw blade, and a top plate connected to the body. The top plate can move between a first position in which the top plate is spaced apart from the body and a second position in which the top surface of the top plate is an extension of the top surface of the body. The top plate has first and second resiliently deformable arms extending from it, spaced apart along the top plate, and the body has first and second recesses formed in it extending substantially perpendicularly to the top surface of the body. The first and second arms on the top plate are inserted in the recesses so that the arms and the recesses define the path for movement of the top plate relative to the body between the first and second position.

Abstract: A contrast system and methods for improving optical detection during a medical procedure, the system involving: at least one tracking marker, each at least one tracking marker comprising a tracking marker coupling feature; and at least one contrast element, each at least one contrast element comprising a contrast element coupling feature and an optically non-reflective feature, the contrast element coupling feature configured to complement the tracking marker coupling feature, each at least one contrast element configured to respectively accommodate, by backing, each at least one tracking marker, and each at least one contrast element configured to respectively facilitate coupling each at least one tracking marker with at least one trackable object through at least one background object via at least one of a contrast element fastening feature and a trackable object fastening feature, whereby at least one of optical contrast and imaging in relation to the at least one tracking marker and the at least one backg

Abstract: A motion-assisted positioning arm for a medical procedure. The positioning arm includes a base, an arm coupled to the base, and an end effector coupled to the arm. The arm includes a plurality of arm segments. The arm includes a plurality of joints for connecting the arm segments. The end effector may be manipulable with six degrees of freedom in a task-coordinate space based on motion by at least one joint in the plurality of joints. The positioning arm includes a processor to: detect manipulation of and determine forces or torques acting on the end effector; determine a surgical mode for constraining movement of the end effector in the task-coordinate space; determine an end effector velocity based on the determined forces or torques and the surgical mode for moving end effector; and apply at least one joint space movement based on the end effector velocity.

Abstract: Methods for controlling bevel etch rate of a substrate during plasma processing within a processing chamber includes securing the substrate on a lower electrode within the processing chamber. A power source is provided. A gas mixture is flowed into the processing chamber. A first match arrangement coupled to an upper electrode is adjusted to control current flowing through the upper electrode to change the upper electrode from a grounded state to a floating state. A second match arrangement coupled to a top ring electrode is adjusted to control current flowing through the top ring electrode so as to control plasma formed above a top edge of the substrate. An extension of the upper electrode is lowered during plasma processing so as to minimize a gap between the extension of the upper electrode and the substrate received on the lower electrode, such that the gap is incapable of supporting plasma formed in the processing chamber.

Abstract: A cutting block comprises a body having a top surface for guiding a saw blade, and a top plate connected to the body. The top plate can move between a first position in which the top plate is spaced apart from the body and a second position in which the top surface of the top plate is an extension of the top surface of the body. The top plate has first and second resiliently deformable arms extending from it, spaced apart along the top plate, and the body has first and second recesses formed in it extending substantially perpendicularly to the top surface of the body. The first and second arms on the top plate are inserted in the recesses so that the arms and the recesses define the path for movement of the top plate relative to the body between the first and second position.

Abstract: The invention provides a device for fitting into a hollow component to provide an indication of whether the hollow component has been deformed, which includes a frame which can be fitted in the) component, and an elongate indicator suspendedly connected to the frame, with any deformation of the frame being visualised as a deflection of the indicator.

Abstract: An end effector is provided for connecting to a positioning arm of a positioning device of a medical navigation system. The end effector comprises a mating component for connecting to an output flange of the positioning arm, a handle portion having a first end and a second end, the first end extending from the mating component, the handle portion including a cable cut-out at the first end, and a camera mount connected to the second end of the handle portion.

Abstract: An optical imaging system for imaging a target during a medical procedure. The imaging system includes an optical assembly including moveable zoom optics and moveable focus optics. The system includes a zoom actuator and a focus actuator for positioning the zoom and focus optics, respectively. The system includes a controller for controlling the zoom and focus actuators independently in response to received control input. The system includes a camera for capturing an image of the target from the optical assembly. The system may be capable of performing autofocus during a medical procedure.

Abstract: An end effector is provided for connecting to a positioning arm of a positioning device of a medical navigation system. The end effector comprises a mating component for connecting to an output flange of the positioning arm, a handle portion having a first end and a second end, the first end extending from the mating component, the handle portion including a cable cut-out at the first end, and a camera mount connected to the second end of the handle portion.

Abstract: A medical navigation system is provided having a positioning device having a positioning arm with a flange at the end of the positioning arm, a controller at least electrically coupled to the positioning device, and an end effector joystick controller for connecting to the flange of the positioning arm. The controller has a processor coupled to a memory and a display. The end effector joystick controller includes a mating component for connecting to the flange of the positioning arm, and a joystick portion extending from the mating component.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, is described. Q can be pyridazin-3-yl, 6-fluoropyridazin-3-yl; R1 can be H; R2 and R3 can each independently be C1-C6 alkyl, or R2 and R3 taken together are —(CH2)3—; or R1 and R2 taken together can be —(CH2)2— and R3 can be —CH3; R4 halo, —CH3, —OCH3, —OCHF2, —OCF3, or —CN; and n can be 0, 1, or 2. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.

Abstract: A locking carabiner includes a body having a first end and a second end. A gate rotatably coupled to the second end about a gate axis, and a locking mechanism rotatably coupled to the gate about a locking mechanism axis. The locking member is configured to engage with the first end, and the gate axis is substantially parallel to, and offset from, the locking mechanism axis. Additionally, the rotation of the locking mechanism is in a substantially similar plane as the rotation of the gate.