Abstract: A catheter may include a catheter body, which may include a proximal end, a distal end, and a lumen formed by an inner wall of the catheter body that extends between the proximal end and the distal end along a longitudinal axis. The distal end of the catheter body may include a distal lumen opening disposed on the longitudinal axis. The distal end may also include a leading edge. The leading edge may form the distal lumen opening and may include an upper and a lower portion. The lower portion of the leading edge may be disposed distally to the upper portion of the leading edge.

Abstract: The invention relates to a spray unit (10) with an axle (20), an atomising disc (30), a spray direction modifying assembly (40), and a liquid applicator (50). The atomising disc is configured to spin about the axle centred on the centre of the disc. The liquid applicator is configured to apply liquid to a surface of the atomising disc. The spray direction modifying assembly is in proximity to the atomising disc. The spray direction modifying assembly comprises at least one air channel (41). The at least one air channel is configured to provide air in proximity to the atomising disc to modify the subsequent trajectory of the liquid droplets that leave the outer edge of the atomising disc.

Abstract: The invention relates to a spray unit comprising an axle (20), a disc (30), a disc shape modifying assembly (40) and a liquid applicator (50). The disc is configured to spin about the axle centred on the centre of the disc. The liquid applicator is configured to apply liquid to a surface of the disc. The disc shape modifying assembly is configured to modify the trajectory of the liquid droplets that leave the spray unit by way of varying the diameter of the disc.

Abstract: Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

Abstract: The invention relates to a spray unit comprising an axle (10), a disc (20), a liquid applicator (40) and a spray direction assembly (50). The disc is configured to spin about the axle centred on the centre of the disc. The liquid applicator is configured to apply liquid to a surface of the disc. The spray direction assembly partially surrounds the disc. The inner surface of the spray direction assembly is configured to modify the trajectory of all liquid that leaves the outer edge of the disc.

Abstract: A computer implemented method for rendering a page that includes one or more dynamic design elements into an output video is described. The method comprises processing the page to generate one or more layers, each layer being either a static layer associated with one or more static design elements of the page or a dynamic layer associated with a single dynamic design element of the page. Output frames are then generated using the layers and then encoded into the output video.

Abstract: A method for reducing the number of images or the length of a video from a digital image collection using a social network, includes receiving a digital image collection captured by a user to be viewed by a viewer; wherein the viewer and the user are members of the same social network and using a processor to access the social network to determine a relationship between a viewer and the user. The method further includes using the processor to determine a set of summarization parameters based on the relationship between the viewer and the user and using the processor to reduce the number of images or the length of the video from the digital image collection using the determined set of summarization parameters to be viewed by the viewer.

Abstract: The present invention relates to an unmanned aerial vehicle (UAV) for agricultural field management. The UAV comprises a control and processing unit (20) and a camera (30). The control and processing unit is configured to control the UAV to fly to a location inside the canopy of a crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crop. The control and processing unit is configured to control the camera to acquire at least one image relating to the crop at the location inside the canopy of the crop and below the vertical height of the crop and/or between a row of a plurality of crops and below the vertical height of the plurality of crops. The control and processing unit is configured to analyse the at least one image to determine at least one disease, at least one pest and/or at least one nutritional deficiency.

Abstract: The disclosed technology for preparing digital samples for synthesis of RF to simulate channels and GNSS satellites using GPUs includes receiving simulated position and velocity of an antenna, dividing the cycle into points to be converted into the synthesized signal, and computing the points. A first LUT includes pseudo random sequences combinable to produce a code that varies over time for encoding the channel, and a second LUT specifies linear combinations of the pseudo random sequences in the first LUT that produce channel codes to produce the digital sample points. Also included is using GPUs to generate the channel code for a point by mapping the channel code and time position, combining the code with data to be encoded, repeatedly applying the using and combining to produce points, using multiple GPU cores to encode sample points concurrently in the cycle, and sending an ordered sequence of points to a converter.

Abstract: A portable sensor system is provided for detecting objects in the environment of the portable sensor system and for being temporarily attached to a mobile object. The portable sensor system includes an environment detection sensor for detecting objects, an attaching device connected to the environment detection sensor for temporarily attaching the portable sensor system to an external surface of the mobile object, and a position determining apparatus for determining a sensor position of the environment detection sensor when the environment detection sensor is attached to the external surface. The position determining apparatus is configured to determine the sensor position relative to the mobile object on the basis of a predetermined geometrical model of the external surface and a region of the external surface detected by the environment detection sensor.

Abstract: The present disclosure relates to TGF-beta antibodies and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The disclosure also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment of various diseases including fibrosis.

Abstract: The present invention relates to an aerial vehicle (10). aerial vehicle comprises a liquid chemical tank (20), at least one liquid spray unit (30), at least one actuator (40), a plurality of sensors (50), and a processing unit (60). The liquid chemical tank is configured to hold a liquid chemical. The at least one liquid spray unit is configured to spray the liquid chemical. The at least one actuator is configured to operate the at least one liquid spray unit. At least one sensor (51) of the plurality of sensors is configured to measure a speed of the aerial vehicle relative to the ground. At least one sensor (52) of the plurality of sensors is a light detection and ranging (LIDAR) sensor configured to measure the direction and distance of airborne particles relative to the aerial vehicle with respect to a fore-aft axis of the aerial vehicle.

Abstract: The present invention relates to method of spraying a field with an unmanned aerial vehicle (UAV). The method comprises: flying an UAV over a crop within a field and spraying the crop with a liquid spray, wherein the UAV comprises a wing extending in directions perpendicular to a fore-aft axis of the UAV, wherein the wing has a span extending from one side of the fore-aft axis to the other side of the fore-aft axis, and wherein spraying the crop comprises spraying substantially all of the crop at a height of the wing above the crop that is less a length of the span of the wing.

Abstract: A method for reducing the number of images or the length of a video from a digital image collection using a social network, includes receiving a digital image collection captured by a user to be viewed by a viewer; wherein the viewer and the user are members of the same social network and using a processor to access the social network to determine a relationship between a viewer and the user. The method further includes using the processor to determine a set of summarization parameters based on the relationship between the viewer and the user and using the processor to reduce the number of images or the length of the video from the digital image collection using the determined set of summarization parameters to be viewed by the viewer.

Abstract: The present invention relates to spray application device(s) for application of an active ingredient(s) to agricultural crops, to vehicle(s) comprising spray application device(s), to method(s) of spray application by the spray application device(s), to computer program element(s) for controlling the spray application device(s), and for computer program element(s) for controlling vehicle(s) comprising spray application device(s).

Abstract: The present invention relates to a disc (10) for a spinning disc liquid atomizer. A surface (20) of the disc comprises a plurality of concentric rings (30) having different radii centred on the centre of the disc. A first concentric ring (40) of an adjacent pair of concentric rings has a surface configured to exhibit a first level of adhesion to the liquid. A second concentric ring (50) of the adjacent pair of concentric rings has a surface configured to exhibit a second level of adhesion to the liquid, and wherein the first level of adhesion is less than the second level of adhesion.

Abstract: Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

Abstract: Antibodies which bind BTLA, and methods of using same, are provided, said antibodies are useful as agents for treating conditions associated with autoimmune disease including treating lupus.

Abstract: The present invention relates to unmanned aerial vehicle for application of an active ingredient to agricultural crops. It is described to hold (310) a liquid comprising the active ingredient in a liquid reservoir housed within or attached to a body of the unmanned aerial vehicle. A liquid application unit is attached to the body of the unmanned aerial vehicle, and the liquid application unit is in fluid communication with the liquid reservoir. The liquid application unit receives (320) at least one input from a processing unit. The at least one input is useable to activate the liquid application unit. The unmanned aerial vehicle lands (330) within an environment to apply the liquid to at least one plant. The liquid application unit is activated (340) at a location determined by the processing unit based on image analysis of at least one image of the environment acquired by a camera.

Abstract: A method comprises rolling a medical implant to reduce a profile of the medical implant. The medical implant comprises a first end and a second end. The method further comprises inserting the medical implant into a catheter, delivering the catheter to a treatment location within a human body, and removing the medical implant from the catheter.