Patents by Inventor Andrew Guarino

Andrew Guarino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200390849
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a strong acid salt of a LHRH agonist or antagonist; b) a biodegradable polymer of poly(lactide-co-glycolide), wherein the ratio of lactide:glycolide of the copolymer is from 50:50 to about 100:0; and c) N-methyl-2-pyrrolidone (NMP), wherein the composition does not contain excess strong acid in addition to the strong acid used to form the salt of the LHRH agonist or antagonist. The composition, when injected, can provide a controlled release of leuprolide for a period of up to 6 months.
    Type: Application
    Filed: December 18, 2017
    Publication date: December 17, 2020
    Inventors: Yuhua LI, Andrew GUARINO
  • Patent number: 8586103
    Abstract: The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: November 19, 2013
    Assignee: Foresee Pharmaceuticals, LLC
    Inventors: Yuhua Li, Andrew Guarino, Benjamin Chien
  • Publication number: 20100034801
    Abstract: The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
    Type: Application
    Filed: February 5, 2009
    Publication date: February 11, 2010
    Applicant: QPS LLC
    Inventors: Yuhua Li, Andrew Guarino, Benjamin Chien
  • Publication number: 20090202481
    Abstract: The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a protein or peptide in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) a protein or peptide covalently conjugated with one or more formulation performance-enhancing compounds. The present invention also provides a method of manufacturing and use of the composition thereof.
    Type: Application
    Filed: February 5, 2009
    Publication date: August 13, 2009
    Applicant: QPS LLC
    Inventors: Yuhua Li, Andrew Guarino, Benjamin Chien