Abstract: Disclosed is a substance which down-regulates the activity of a MAST gene, or the activity of a transcription or translation product of a MAST gene, for use in the prevent and/or treatment of an inflammatory skin condition in a mammalian subject.

Abstract: Disclosed is a substance which down-regulates the activity of a MAST gene, or the activity of a transcription or translation product of a MAST gene, for use in the prevent and/or treatment of an inflammatory skin condition in a mammalian subject.

Abstract: A system and method that provides for a crate consisting of main flooring section and additional side supports and horizontal beam bracing, that when assembled give the crate the rigidity to be stacked vertically, with multiple units on top of each other, with no other supporting structure. Safe lifting is ensured by fully enclosed fork pockets across the crate base. Safe stacking is ensured by using ISO shipping container casting, as part of the crate design along with top lug assembly to provide positive lateral restraint when stacked.

Abstract: One aspect of one embodiment of the present invention is a frame system for modular berthing compartments wherein a plurality of the frames can also function as a frame for a modular tent system, which frames are assembled on site and easily transportable and optimized to ship very efficiently disassembled. The assembled frame creates an environment that maximizes the volumetric space to provide sleeping accommodation or utility spaces in a high-density configuration.

Abstract: The invention provides a method for obtaining information useful to determine the effect of the use of sun protection products on the skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual, wherein the skin cells include epidermal skin cells; and (b) observing cytosine methylation of at least two CpG loci in the genomic DNA selected from the group consisting of: cg02066936 cg16929393 cg05715751 cg21177821 cg05504117 cg00772091 cg06066180 cg00675160 cg00067720 cg02491003 cg24490133 cg05355684 cg19283806 cg23976431 cg00025972 cg07050101 cg10557907 cg25588389 cg24114899 cg22695351 cg24105685 cg13181164 cg04258138 cg13181974 cg24357619 cg17196051 cg27546066 cg01203651 cg09496748 cg00297912 cg19757573 cg03243551 cg10634273 cg23225508 cg10397765 cg02037307 cg15084618 cg25677261 cg10294853 cg19145082 cg12577010 cg24489344 cg08243465 cg04935109 cg19720260 cg16293892 cg16210355 cg03597159 cg26837962 cg18582260 cg10624914 cg12474705 cg04425614 cg

Abstract: The invention provides a method for obtaining information useful to determine the effect of sun exposure on the skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual, wherein the skin cells include epidermal skin cells; and (b) observing cytosine methylation of at least two CpG loci in the genomic DNA selected from the group consisting of: cg02066936 cg16929393 cg05715751 cg21177821 cg05504117 cg00772091 cg06066180 cg00675160 cg00067720 cg02491003 cg24490133 cg05355684 cg19283806 cg23976431 cg00025972 cg07050101 cg10557907 cg25588389 cg24114899 cg22695351 cg24105685 cg13181164 cg04258138 cg13181974 cg24357619 cg17196051 cg27546066 cg01203651 cg09496748 cg00297912 cg19757573 cg03243551 cg10634273 cg23225508 cg10397765 cg02037307 cg15084618 cg25677261 cg10294853 cg19145082 cg12577010 cg24489344 cg08243465 cg04935109 cg19720260 cg16293892 cg16210355 cg03597159 cg26837962 cg18582260 cg10624914 cg12474705 cg04425614 cg15701237 cg09055205 cg

Abstract: The invention provides a method for obtaining information useful to determine the intrinsic age of skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual; and (b) observing cytosine methylation of >30 CpG loci in the genomic DNA selected from the group consisting of: cg19381811 cg19670290 cg15393490 cg01465824 cg04999352 cg09046979 cg10426318 cg09077126 cg24374161 cg14896948 cg14412967 cg16937583 cg17508941 cg24757926 cg03936449 cg17953764 cg00442430 cg06621744 cg08076830 cg06882058 cg25351606 cg02662828 cg20897936 cg07878486 cg21992250 cg06335867 cg15171839 cg09017434 cg04044664 cg20442599 cg15488596 cg10384245 cg23368787 cg07960624 cg08622677 cg13848598 cg02273797 cg22593953 cg23213887 cg20234007 cg26492368 cg06470727 cg13612317 cg09432376 cg12530994 cg05457221 cg04766371 cg03614721 cg22624391 cg27369542 cg18322569 cg27284120 cg21303763 cg05238606 cg16300030 cg00085493 cg11239720 cg23942526 cg10568624 cg07217499 cg03405983 cg255908

Abstract: The invention provides a method for obtaining information useful to determine the extrinsic age of skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual; and (b) observing cytosine methylation of >30 CpG loci in the genomic DNA selected from the group consisting of: cg24756227 cg06036239 cg11530289 cg04659582 cg03445800 cg04941246 cg22264616 cg15902864 cg13672200 cg00530720 cg00866690 cg25034941 cg01246665 cg24393844 cg19058262 cg12051116 cg02000606 cg18263166 cg06900899 cg03819134 cg15596932 cg11359720 cg03195377 cg15382568 cg00092551 cg26169991 cg04194664 cg13984289 cg22032385 cg05482603 cg09851620 cg23621013 cg20710730 cg18716076 cg06142351 cg12177909 cg15394860 cg02707854 cg13062888 cg23518497 cg00394718 cg01544580 cg06635832 cg11994639 cg19974120 cg06299192 cg21497480 cg02947450 cg13836638 cg12732514 cg24641302 cg05705140 cg06531870 cg24902858 cg22797031 cg26134692 cg14847243 cg22827250 cg10549088 cg18366919 cg15971980 cg255879

Abstract: A military deployable ramp system assembled from sectional modules and used to load/unload heavy wheeled and tracked vehicles on/off rail cars and other transport platforms. The design of the system affords potential to handle such vehicles in a wide range of environments, particularly at remote train track locations. The assembled modular ramp consists of two main parallel load-bearing ramp tracks, connected to each other via central bridging supports. Sections slide together vertically and connect using structural angles which are retained in opposing guide channels, eliminating the need for fixing hardware. Once assembled the ramp can be dismantled by lifting off each section clear of the others in order. The ramp sections independently find their own level relative to each other on unprepared ground. Additional restraint is provided by integrated lashing points for sections to be tethered together to enhance its assembled rigidity.

Abstract: Disclosed is a substance which down-regulates the activity of a MAST gene, or the activity of a transcription or translation product of a MAST gene, for use in the prevent and/or treatment of an inflammatory skin condition in a mammalian subject.

Abstract: This invention relates to an apparatus for and a method of measuring skin glow and/or skin radiance and/or skin shine and/or the biological age of the skin of an individual. As an individual ages, their appearance changes due to structural alterations to their tissues. These visible signs of aging, such as loss of skin glow or radiance, mean that other individuals are an indication of the age of an individual. In a population of individuals, some will appear younger and some will appear older than their chronological age. In these cases the aforementioned visible signs of aging are an indication of how well the skin of the individual is aging, in other words an indication of the biological age of the skin of the individual. Trained human age assessors are able to reproducibly determine the biological age of the skin of the individual. However automation would facilitate its use in almost any research or consumer setting.

Abstract: A portable micro-organism inactivation system comprising: a casing mounting, a UV radiation source, a pump, and releasable tube support for supporting an elongate tube to define a flow path extending therethrough which is substantially free of substantial discontinuities are provided by the present invention. The elongate tube has a first portion and a second portion wherein the first portion has a UV-transparent wall. The first portion extends in close proximity to the UV radiation source within an irradiation zone thereof while the second portion is interfaced with the pump for pumping of fluid through the system so that substantially the whole of said individual fluid unit is exposed to a similar micro-organism inactivating level of UV-irradiation, while minimizing damage to the desired components thereof. The invention also provides a method of micro-organism inactivation in a fluid using a system of the invention.

Abstract: The present invention provides a method for monitoring temporal variation in irradiating radiation received by a material, comprising the steps of: providing a flow of an actinometric fluid (4) through a monitoring portion (22) of a passage (10), such that said actinometric fluid therein intercepts a flux of said irradiating radiation (13) representative of the flux of the radiation received by the material; and analysing said actinometric fluid (4) downstream of said monitoring portion (22) so as to measure a change in said actinometric fluid due to irradiation by said intercepted radiation flux. The invention also provides an apparatus for use in the above method.

Abstract: A portable micro-organism inactivation system (1) comprising: a casing mounting (2), a UV radiation source (10), a pump (9), and releasable tube support (3) for supporting an elongate tube (4) to define a flow path extending therethrough which is substantially free of substantial discontinuities are provided by the present invention. The elongate tube (4) has a first portion (5) and a second portion (8) wherein the first portion (5) has a UV-transparent wall. The first portion (5) extends in close proximity to the UV radiation source (10) within an irradiation zone thereof while the second portion is interfaced with the pump (9) for pumping of fluid through the system (1) so that substantially the whole of said individual fluid unit is exposed to a similar micro-organism inactivating level of UV-irradiation, whilst minimising damage to the desired components thereof. The invention also provides a method of micro-organism inactivation in a fluid using a system of the invention.

Abstract: The present invention relates to a method and apparatus for effective inactivation of micro-organisms in fluids with relatively high absorbance so as to limit damage. The apparatus has a large diameter passage (2) flow-through UV radiation system with a static mixer system (11) providing an intensive fluid flow mixing within an irradiation area in which the fluid flow is controlled to provide a flow rate not less than a minimum flow rate corresponding to a maximum fluid residence time within said irradiation area required for efficient mixing, and a maximum flow rate providing a minimum residence time for effective inactivation.

Abstract: A device suitable for use in the sterilization of a fluid such as a biological fluid or a fraction thereof, containing lymphocytes and/or micro-organisms, comprising a vessel having an inlet and an outlet and a passage which extends non-tortuously therebetween. A heat exchange device with a heat exchange surface is in substantially direct thermal contact with the interior of the passage. A temperature controller maintains the temperature of fluid in the passage below a temperature at which fluid components may form insoluble particles during irradiation. The passage has a wall which is substantially transparent to a lymphocyte and/or micro-organism inactivating radiation. The passage contains a static mixer device for thoroughly mixing the fluid so as to bring the whole of the fluid into an irradiation zone extending along and adjacent the passage walls and into contact with the heat exchange surface.

Abstract: The present invention relates to the sterilization (in the sense of rendering free from cells or organisms capable of division e.g. lymphocytes, protozoans, bacteria, viruses) of blood or other fluids. The present invention provides an apparatus (1) for use in the ultraviolet irradiation of the fluid (8), which comprises a vessel (2) having side walls (4) substantially transparent to ultraviolet radiation of an effective inactivating wavelength; a turning vessel support (3) for supporting and allowing said vessel to turn on said support which is driven (23) so as to directly or indirectly turn the vessel on the support. U.V. irradiation means are provided for irradiating at least part of the turning vessel (2). In use of the apparatus a thin layer (9) of the fluid (8) adjacent the wall surface (10) of the side wall (4) is carried round past the ultraviolet irradiation means (7) and sterilized thereby and mixed with the main body of said fluid (8).