Abstract: A protective housing structure for a heating, ventilation, and air conditioning (HVAC) system comprises a first end and a second end with a centerline extending there between. The protecting housing structure includes a cover section that is located between the first end and second end. The cover section comprises a dome-shaped top panel that is rigidly attached to a first sidewall and a second sidewall.

Abstract: Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and geranylgeranyltransferase-I (GGT-1) inhibitors (GGTI) were developed as anticancer agents from based on an ethylenediamine scaffold. On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally simple and readily derivatized, facilitating extensive structure-activity relationship studies. The most potent inhibitor is compound exhibited an in vitro hFTase IC50 value of 25 nM and a whole cell H-Ras processing IC50 value of 90 nM. Several of the inhibitors proved highly selective for hFTase over the related prenyltransferase enzyme geranylgeranyltransferase-I (GGTase-I).

Abstract: The method involves aggregating post text, information about the type of content that has been posted, the post's creation time (time stamp), geographical origin (geo tag) and the username and storing it in a database. In order to search content that has been stored a web-server prompts clients for their search terms which it then parses. The webserver is programmed to identify portions of the search terms as corresponding to locations, hashtags or general search keywords. The method then involves interrogating the database to return relevant results from the vast array of social media content. The results are initially presented back to clients as links comprising markers on a map described on the screen of the client's device. The client can scroll the map view in order to also see the results in a list format. The client can then refine the results according to a number of filters.

Abstract: A furnace has a primary heat exchanger tube, a secondary heat exchanger comprising a plurality of secondary heat exchanger tubes, a hot header configured to provide a fluid flow path between an output of the primary heat exchanger tube to an input of the secondary heat exchanger, and a perforated fluid flow plate disposed at least partially within the hot header.

Abstract: A random number generator includes a first circuit producing a random sequence of values, the first circuit having an adjustable input that changes the entropy of the random sequence of numbers; a second circuit receiving the random sequence of values from the first circuit and producing an output indicative of the degree of entropy of the random sequence of values, and a third circuit that adjusts the adjustable input of the first circuit in response to the output of the second circuit.

Abstract: The present invention relates to a system and method for interacting with a social network. The method includes displaying a web page provided by a content provider on a user device. The web page includes at least one social network access item. The social network access item may be selected by a user of the user device, with a first type of selection causing a link to an online resource associated with a social network provider to be followed by the web browser, the online resource enabling the user to login to a social network. Receiving a second type of selection causes at least one control option to be displayed within the web page. The control option may be for saving details of the web page to a storage location remote from the user device and provided by the social network provider, or accessing the details of at least one web page previously saved by the user from the storage location.

Abstract: A system for reseeding a pseudo random number generator to generate pseudo random numbers includes a true random number generator generating a true random number, a storage device storing the generated true random number, a pseudo random number generator generating pseudo random numbers using the stored true random number as a seed, and a controller coupled to the true random number generator and the pseudo random number generator to (1) generate a new true random number concurrently with the operation of the pseudo random number generator, and storing the new true random number, and (2) reseed the pseudo random number generator with the new true random number.

Abstract: A sensor surrogate (120) for causing a heating, ventilating, and air conditioning (HVAC) system (110) to maintain a desired room temperature, contains a temperature sensor (122) for determining an actual room temperature and logic embodied on at least one non-transitory computer readable medium (130). The logic (130) is configured to perform the steps of: calculating a current low temperature that is lower than a pre-programmed HVAC system temperature and providing the HVAC system with a first signal that represents the calculated current low temperature, if the desired temperature is above the pre-programmed HVAC system temperature; and calculating a current high temperature that is above the pre-programmed HVAC system temperature and providing the HVAC system (110) with a second signal that represents the calculated current high temperature, if the desired room temperature is below the pre-programmed HVAC system temperature.

Abstract: A method and apparatus to receive a measure of heart rate for a user while the user is exercising on a stationary exercise device, calculate a speed of the user based on the measure of heart rate, and display on a display device viewable by the user a location of where the user would be along a selected route based on the user's speed.

Abstract: A system and method of accessing at least one hub is provided, wherein the system displays a selectable item within an interface, and receives selection of the selectable item from a user of the interface. A first type of selection by the user causes a function to be performed, and a second type of selection by the user causes user specific information to be accessed and used in bidirectional communication with the hub.

Abstract: A turbine-driven alternator (i.e., a turbomachine) suitable for generating electrical power from process gas waste energy. In particular suitable for very high density process gases such as super critical CO2, R134a, R245fa, etc. The turboalternator comprises two separate machines, specifically, a turbine device and an alternator device operatively connected together by a coupling shaft. The rotating shaft assemblies for each machines on the turbine side and the alternator side are supported by hydrodynamic foil gas bearings. The foil gas bearings use process gas at the turbine side, enabling high-pressure operation (˜3000 psia) and thrust load balancing. At the alternator side, cooling fluid is used in the foil gas bearings, enabling high-speed (˜40,000 rpm), low-windage, oil-free operation with closed-loop shaft cooling.

Abstract: The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome proliferators-activated receptors, among others. Compounds according to the present invention may be useful in the treatment of a variety of disease states or conditions which are mediated through nuclear receptors.

Abstract: The present invention relates to porphyrin analogues, their use in pharmaceutical compositions alone, or combination with other agents and in the treatment and/or prophylaxis of flaviviridae viral infections, especially hepatitis C viral infection, and secondary disease states and/or conditions associated with same.

Abstract: The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (LD) of the semiconductor material of which the semiconductor layer is formed.

Abstract: The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome proliferators-activated receptors, among others. Compounds according to the present invention may be useful in the treatment of a variety of disease states or conditions which are mediated through nuclear receptors.

Abstract: Formula (I): Where R1 is an optionally substituted C3-C12 hydrocarbyl group (preferably a cyclic alkyl group), an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group; R is a C(O)yR? group (preferably forming an optionally substituted C2-C5 acyl group), or a S(O)xR? group, where y is 0 or 1 and x is 0, 1 or 2 and R? is H or an optionally substituted C1-C12 alkyl group, or R? is an optionally substituted C5-C12 cycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group; R5, R6, R7, R8, R9 and R10 are each independently selected from H, an optionally substituted C1-C12 hydrocarbyl group, including a C5-C12 cycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group, or R5 and R6, R7 and R8 or R9 and R10 together form a keto (C?O) group; RN is H

Abstract: Disclosed are a variety of methods for achieving enhanced expression from a target nucleotide sequence in a plant e.g. comprising the step of transiently introducing into a tissue of a plant (e.g. a leaf) a first nucleic acid comprising the target nucleotide sequence and a second nucleic acid encoding a Post Transcriptional Gene Silencing (PTGS) suppressor protein (preferably of viral or plant origin), wherein the first and second nucleic acids are comprised within a single binary vector, construct, or the first and second nucleic acid sequences are comprised within a first binary vector and a second binary vector construct respectively. The plant tissue may then be harvested for the protein. Such methods can give much higher levels of gene expression than are obtainable using stable transgenes, or certain replicating vectors.

Abstract: Methods, systems, and software are disclosed for configuring an ATM. The ATM receives one or more configuration messages in an XML-based format. The ATM interprets the one or more configuration messages. The ATM restricts one or more ATM operations based on at least a portion of the one or more configuration messages.

Abstract: Methods, systems, and software are disclosed for configuring an ATM. The ATM receives an online/offline configuration message that specifies one or more conditions when the ATM is to go online. The ATM goes offline and performing zero or more offline transactions. The ATM goes online based at least in part on at least a portion of the online/offline configuration message. The online/offline configuration message is in an XML-based format.