Patents by Inventor Andrew Hamilton

Andrew Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130035995
    Abstract: A system and method of accessing at least one hub is provided, wherein the system displays a selectable item within an interface, and receives selection of the selectable item from a user of the interface. A first type of selection by the user causes a function to be performed, and a second type of selection by the user causes user specific information to be accessed and used in bidirectional communication with the hub.
    Type: Application
    Filed: August 2, 2012
    Publication date: February 7, 2013
    Inventors: Matthew Campbell Patterson, Andrew Hamilton Malcolm
  • Publication number: 20120306206
    Abstract: A turbine-driven alternator (i.e., a turbomachine) suitable for generating electrical power from process gas waste energy. In particular suitable for very high density process gases such as super critical CO2, R134a, R245fa, etc. The turboalternator comprises two separate machines, specifically, a turbine device and an alternator device operatively connected together by a coupling shaft. The rotating shaft assemblies for each machines on the turbine side and the alternator side are supported by hydrodynamic foil gas bearings. The foil gas bearings use process gas at the turbine side, enabling high-pressure operation (˜3000 psia) and thrust load balancing. At the alternator side, cooling fluid is used in the foil gas bearings, enabling high-speed (˜40,000 rpm), low-windage, oil-free operation with closed-loop shaft cooling.
    Type: Application
    Filed: May 31, 2012
    Publication date: December 6, 2012
    Applicant: R&D Dynamics Corporation
    Inventors: Giridhari L. Agrawal, Charles W. Buckley, Ali Shakil, Andrew Hamilton Coward
  • Patent number: 8084471
    Abstract: The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome proliferators-activated receptors, among others. Compounds according to the present invention may be useful in the treatment of a variety of disease states or conditions which are mediated through nuclear receptors.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: December 27, 2011
    Assignee: Yale University
    Inventors: Andrew Hamilton, Jorge Becerril
  • Publication number: 20110064694
    Abstract: The present invention relates to porphyrin analogues, their use in pharmaceutical compositions alone, or combination with other agents and in the treatment and/or prophylaxis of flaviviridae viral infections, especially hepatitis C viral infection, and secondary disease states and/or conditions associated with same.
    Type: Application
    Filed: September 8, 2010
    Publication date: March 17, 2011
    Applicant: YALE UNIVERSITY
    Inventors: Andrew HAMILTON, Yung-Chi CHENG
  • Publication number: 20100297608
    Abstract: The systems and methods described herein include a sensor for suitable for sensing chemical and biological substances. The sensor comprises a semiconductor layer formed in or on a substrate and a channel having nano-scale dimensions formed in the semiconductor layer, where the structure creates an electrically conducting pathway between a first contact and a second contact on the semiconductor layer. In certain preferred embodiments, the nano-scale channel has a trapezoidal cross-section with an effective width and exposed lateral faces, where the effective width is selected to have same order of magnitude as a Debye length (LD) of the semiconductor material of which the semiconductor layer is formed.
    Type: Application
    Filed: December 6, 2007
    Publication date: November 25, 2010
    Inventors: Eric D. Stern, Tarek M. Fahmy, Mark A. Reed, Pauline N. Wyremback, Daniel Turner-Evans, Andrew Hamilton, David A. Lavan, James F. Klemic, David A. Routenberg
  • Publication number: 20090220586
    Abstract: The present invention relates to compounds, pharmaceutical compositions and methods which inhibit the binding of coactivator proteins in nuclear receptors, including estrogen receptors (alpha and/or beta), androgen receptors, thyroid receptors and peroxisome proliferators-activated receptors, among others. Compounds according to the present invention may be useful in the treatment of a variety of disease states or conditions which are mediated through nuclear receptors.
    Type: Application
    Filed: September 4, 2007
    Publication date: September 3, 2009
    Applicant: YALE UNIVERSITY
    Inventors: Andrew Hamilton, Jorge Becerril
  • Publication number: 20080312287
    Abstract: Formula (I): Where R1 is an optionally substituted C3-C12 hydrocarbyl group (preferably a cyclic alkyl group), an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group; R is a C(O)yR? group (preferably forming an optionally substituted C2-C5 acyl group), or a S(O)xR? group, where y is 0 or 1 and x is 0, 1 or 2 and R? is H or an optionally substituted C1-C12 alkyl group, or R? is an optionally substituted C5-C12 cycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group; R5, R6, R7, R8, R9 and R10 are each independently selected from H, an optionally substituted C1-C12 hydrocarbyl group, including a C5-C12 cycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group, or R5 and R6, R7 and R8 or R9 and R10 together form a keto (C?O) group; RN is H
    Type: Application
    Filed: March 17, 2006
    Publication date: December 18, 2008
    Applicant: University of Washington
    Inventors: Andrew Hamilton, Frederick Buckner, Matthew Glenn, Wesley Van Voorhis, Said Sebti
  • Publication number: 20070292862
    Abstract: Disclosed are a variety of methods for achieving enhanced expression from a target nucleotide sequence in a plant e.g. comprising the step of transiently introducing into a tissue of a plant (e.g. a leaf) a first nucleic acid comprising the target nucleotide sequence and a second nucleic acid encoding a Post Transcriptional Gene Silencing (PTGS) suppressor protein (preferably of viral or plant origin), wherein the first and second nucleic acids are comprised within a single binary vector, construct, or the first and second nucleic acid sequences are comprised within a first binary vector and a second binary vector construct respectively. The plant tissue may then be harvested for the protein. Such methods can give much higher levels of gene expression than are obtainable using stable transgenes, or certain replicating vectors.
    Type: Application
    Filed: November 20, 2006
    Publication date: December 20, 2007
    Inventors: David Baulcombe, Olivier Voinnet, Andrew Hamilton
  • Publication number: 20070162388
    Abstract: Methods, systems, and software are disclosed for configuring an ATM. The ATM receives one or more configuration messages in an XML-based format. The ATM interprets the one or more configuration messages. The ATM restricts one or more ATM operations based on at least a portion of the one or more configuration messages.
    Type: Application
    Filed: January 9, 2006
    Publication date: July 12, 2007
    Inventors: Andrew Hamilton, Stephen MacPhail, Wolf Rossmann
  • Publication number: 20070162389
    Abstract: Methods, systems, and software are disclosed for configuring an ATM. The ATM receives an online/offline configuration message that specifies one or more conditions when the ATM is to go online. The ATM goes offline and performing zero or more offline transactions. The ATM goes online based at least in part on at least a portion of the online/offline configuration message. The online/offline configuration message is in an XML-based format.
    Type: Application
    Filed: January 9, 2006
    Publication date: July 12, 2007
    Applicant: NCR Corporation
    Inventors: Andrew Hamilton, Stephen MacPhail, Wolf Rossmann
  • Publication number: 20070143225
    Abstract: The invention features a method for authorizing access to an ATM. An ATM receives from a user first biometric information and a first identifier corresponding to at least the user. The ATM transmits the first identifier to a first computer outside the ATM. The first computer reads second biometric information from storage based at least in part on the first identifier. The first biometric information with the second biometric information are compared to generate comparison information. The ATM then authorizes user access to financial transactions based at least in part on the comparison information.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 21, 2007
    Inventors: Andrew Hamilton, Stephen MacPhail, Wolf-Dieter Rossmann
  • Publication number: 20070131757
    Abstract: The invention features a method for administering an ATM. One or more transactions are conducted at the ATM and the ATM generates one or more logs corresponding to the transactions. A communications link is established between the ATM and a computer. The logs are represented in an XML-based format and are transmitted over the communications link in that format. XML stands for extensible Markup Language.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 14, 2007
    Inventors: Andrew Hamilton, Stephen MacPhail, Wolf-Dieter Rossmann
  • Publication number: 20070123592
    Abstract: The present invention relates to compounds and pharmaceutical compositions based upon terephthalamide which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention. Methods of inhibiting the binding of proteins to their binding sites are other aspects of the present invention.
    Type: Application
    Filed: February 22, 2005
    Publication date: May 31, 2007
    Applicant: YALE UNIVERSITY
    Inventors: Andrew Hamilton, Hang Yin
  • Publication number: 20070060521
    Abstract: Signal Transducer and Activator of Transcription (STAT) proteins have a fundamental role cell signaling, and are activated by a large number of cytokines and growth factors. One member of the STAT family, STAT3, has a critical role in oncogenesis. The present invention relates generally to disruption of the pathway of STAT3 signaling in the treatment of human cancer. STAT3 activation is shown to be present in diverse tumor cell lines and tumors, to promote oncogenesis, to inhibit apoptosis, and to reduce sensitivity to chemotherapeutic agents. Inhibition of STAT3 signaling induces apoptosis specifically in tumor cell lines, and increases sensitivity to chemotherapeutic agents. The invention relates more particularly to methods, compositions, means of administering such compositions, and means for identifying such compositions for the inhibition of STAT3 intracellular signaling in the treatment of human cancers.
    Type: Application
    Filed: August 28, 2006
    Publication date: March 15, 2007
    Inventors: Richard Jove, William Dalton, Said Sebti, Hua Yu, Richard Heller, Mark Jaroszeski, Richard Gilbert, Andrew Hamilton
  • Publication number: 20070005679
    Abstract: One embodiment of a method includes the steps of a client subsystem receiving a set of initial search results from a server subsystem, a rule engine initiating a scan of the client subsystem to collect technical information associated with the client subsystem, and the rules engine filtering the set of initial search results at the client subsystem. The filtering step is based on the collected technical information.
    Type: Application
    Filed: June 21, 2005
    Publication date: January 4, 2007
    Inventors: Richard Bui, Charles Letterman, Andrew Hamilton, Justin Prindle
  • Publication number: 20060229284
    Abstract: This invention discloses methods of treating neovasculature diseases of the eye through the administration of a photosensitizing agent and subsequent exposure to light of specific wavelength sufficient to photoactivate the photosensitizing agent to occlude one or more vessels in the neovasculature for an extended period of time. Diseases treatable under this invention, include, for example: diabetic retinopathy; macular degeneration; subfoveal choroidal neovascularization, malignant uveal melanomas and other maladies of the human or animal eye or body.
    Type: Application
    Filed: December 13, 2005
    Publication date: October 12, 2006
    Inventors: Paula Mahoney, Louise Culham, Brian McIlroy, Gregory Heacock, Andrew Hamilton, John Marshall
  • Publication number: 20060172044
    Abstract: A method for storing and transporting fruit, particularly bananas, so as to provide an optimized atmosphere for ripening of the fruit, is disclosed. The method utilizes fruit placed within a flexible bag which is placed in a box comprising a container and a lid. In this method, the lid is removed from the box and the neck of the flexible bag is opened so that the fruit is open to the atmosphere. A flexible cover, which is at least partially gas-permeable, is placed over the opening of the container; and the lid is replaced on the box over the flexible cover.
    Type: Application
    Filed: November 30, 2005
    Publication date: August 3, 2006
    Inventors: Raul Fernandez, Andrew Hamilton, Franklin Sanabria Vargas, Francisco Rodriguez Murillo
  • Publication number: 20060167269
    Abstract: The present invention relates to compounds according to the formula (I): Where RA is a C1-C10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group according to the formula (II): RB is a C1-C10 substituted or unsubstituted linear, branch-chained or cyclic alkyl or alkenyl group or a phenyl group of the formula (III): R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are each independently selected from H, C1-C10 (preferably a C1-C4) alkyl or alkenyl group, CF3, F, Cl, Br, I, CN, NO2, NH2, NHR, NRR, COR (acyl group), OR (hydroxyl or ether group), CO2R (carboxylic acid or ester group), or COSR (thioester group) where R is H or a C1-C10 (preferably a C1-C4) alkyl or alkenyl group, an unsubstituted or substituted aryl (preferably, phenyl) or heterocycle group, or a (IV) group, where R3 is H, a C1-C10 (preferably a C1-C4) alkyl, alkenyl, ether or a thioether group; and R11 and R12 are independently selected from H or a C1-C3 alkyl or alkenyl group, or a pharmaceutically ac
    Type: Application
    Filed: July 11, 2002
    Publication date: July 27, 2006
    Inventors: Andrew Hamilton, Wesley Van Voorhis, Kohei Yokoyama, Fredericks Bucker, Junko Ohkanda, Michael Gelb, Jeffrey Lockman
  • Publication number: 20060168669
    Abstract: Provided are methods of screening for the occurrence of gene silencing (e.g. post transcriptional gene silencing) in an organism (e.g. a plant or animal), which method comprises the steps of: (i) obtaining a sample of material from said organism, (ii) producing a nucleic acid extract from said sample, (iii) analysing said extract such as to determine the presence or absence of short RNA molecules which are approximately 25 nucleotides in length (SRMs) in said nucleic extract, (iv) correlating the presence of said SRMs in the extract with the occurrence of gene silencing in said organism. The SRMs are preferably short anti-sense RNA molecules (SARMs). Also provided are associated methods for detecting the silencing of a target gene in an organism.
    Type: Application
    Filed: March 27, 2006
    Publication date: July 27, 2006
    Inventors: David Baulcombe, Andrew Hamilton
  • Publication number: 20060084596
    Abstract: Growth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. The growth factor binding molecules specifically bind various growth factors and are suitable for treating a subject having tumors or restinosis. In one embodiment a platelet-derived growth factor binding molecule is disclosed that is used to inhibit tumor growth and angiogenesis in solid tumors.
    Type: Application
    Filed: September 14, 2005
    Publication date: April 20, 2006
    Inventors: Said Sebti, Andrew Hamilton