Abstract: The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention include compounds of the formula RY*L (where Y* represents phosphotyrosine), with the R group at the Y-1 position. Peptidomimetics of the invention disrupt Stat3 activation and function. Peptidomimetics of the invention significantly inhibit tumor cell growth and induce tumor cell death.

Abstract: Tombstoning susceptibility and reflow peak temperature reduction of solder alloys, in particularly lead-free solder alloys, has been found to be achieved effectively by mixing the solder alloy in the form of an alloy paste with a low melting alloy utilised in powder form, in particular a Bi-containing alloy.

Abstract: The present invention provides a system of automated data driven tools which are integrated to provide an orderly and efficient set of concrete, specific and useful plans to help companies attain organizational and operational excellence. A system is disclosed which includes a set of ePerformance metric development tools, a set of BestPeople tools for force planning and analysis, with a companion set of eLearning tools to provide strategic employee development assistance and a set of eJourney management tools to assist in self measurement, metric comparisons, and plans development. An exemplary preferred embodiment is described which teaches a new and unique workforce transformation system to illustrate a concrete specific implementation result.

Abstract: Disclosed is a method for automatically re-provisioning an appliance server without significant user-interaction. The disk drive of a server to be utilized as an appliance server is partitioned into at least three partitions, including a systems partition, a network operating system partition, and an images partition. A re-provisioning utility is provided, which, when activated by a user, removes the present application from the server and forwards it to a storage location on the network or in a fourth storage partition and installs another application on the server. The system is re-booted and re-configured to provide full operation of the new application.

Abstract: A run-time engine may be utilized to execute software applications. In particular, a user may develop customized application utilizing a development tool. The development tool provides a graphical user interface method of creating software application utilizing visual languages such as VISUAL BASIC, VISUAL C, etc. The resulting software application may be a combination of pseudo-code, compiled program scripts, graphical user interface definitions, etc. The software application(s) may be transmitted to a mobile device (e.g., a two-way text pager) for storage and execution. When a user activates the software application on the mobile device, the run-time engine is instantiated and the software application. Accordingly, by executing the run-time engine, the software application may generate screen displays on-the-fly with a minimal amount of storage space required by the software application.

Abstract: Expression of genes inserted into plants by transformation is controlled by the use of a promoter selected from Aco1, Aco2 and Aco3, the sequences of which are given. The level of expression obtained by use of these promoters varies with the stage of development of the plant.

Abstract: A paintbrush connectable to an extension is provided. The paintbrush has a threaded bore for threaded engagement with an extension pole. At least one handle having a sleeve portion can be slid over the extension pole and secured thereto to facilitate more accurate control of the paintbrush. The handle is infinitely adjustable along the length of the extension pole.

Abstract: A compound of the formulaC.sup.0 BwhereinC.sup.0 stands for ##STR1## A representing O or 2H, and R.sub.0 representing SH, NH.sub.2, or C.sub.x H.sub.y --SO.sub.2 --NH--, wherein C.sub.x H.sub.y is a straight chain saturated or unsaturated hydrocarbon, with x being between 1 and 20 and y between 3 and 41, inclusive; andB stands for --NHR, where R is an aryl group.The compounds are useful for inhibiting p21ras farnesyltransferase.

Abstract: Compounds which inhibit prenyl transferases, particularly farnysyltransferase and geranylgeranyl transferase I, processes for preparing the compounds, pharmaceutical compositions containing the compounds, and methods of use.

Abstract: Eddy current loss is a significant problem in high speed permanent magnet alternator/motors. Leakage flux from the rotor magnets 32, which flows through any stationary electrically conductive material such as a bearing housing 12 will result in eddy current loss. The invention uses a magnetic flux barrier means 29,36 to prevent magnetic flux leakage from the magnets 32 to the stationary electrically conductive material 12. The flux barrier means may comprise a diverter disk 29 made from a magnetically permeable material which is located on the shaft 18 next to the rotor 26 and rotates integrally with the rotor. Alternatively it may comprise a barrier ring 36 made from an electrically conductive material which is stationary on the end of the stator 27 and extends across the air gap 38 between the rotor 26 and the stator 27.

Abstract: Peptidomimetics of the formula C-AMBA-X where C is cysteine, X is, for example, methionine or phenylalanine and AMBA is a hydrophobic spacer, notably 3-aminomethylbenzoic acid. These compounds are effective inhibitors of p21ras farnesyltransferase. Other modifications including alternative spacers for AMBA, and replacement of the A.sub.1 A.sub.2 X component of known CA.sub.1 A.sub.2 X tetrapeptides by a non-peptide aryl or heterocyclic component are also disclosed as are various phosphorylated and arylated derivatives of peptides and peptidomimetics. Pro-drugs made by functionalizing terminal amino and carboxylic acid groups of peptides and peptidomimetics are also disclosed. Such functionalized derivatives demonstrate increased cell uptake. Other structural modifications are also referred to.

Abstract: Peptidomimetics of the formula C.beta.X where C is cysteine, X is any naturally occuring amino acid, and .beta. is a hydrophobic spacer, most notably 2-phenyl-4-aminobenzoic acid. These compounds are effective inhibitors of p2lras farnesyltrasferase, block Ras-dependent oncogenic signalling and inhibit human tumor growth in vivo in animal models. Pro-drugs made by functionalizing terminal amino and carboxylic acid groups of peptides and peptidomimetics are also disclosed. Such functionalized derivatives demonstrate increased cell uptake. Other structural modifications are also disclosed.

Abstract: A compound of the formulaC.sup.1 Rwhere C.sup.1 is 3-mercapto-2-amino-propylamino and R is an aryl group. The compounds are useful for inhibiting p21ras farnesyltransferase.

Abstract: Peptidomimetics of the formula C-AMBA-X where C is cysteine, X is, for example, methionine or phenylalanine and AMBA is a hydrophobic spacer, notably 3-aminomethylbenzoic acid. These compounds are effective inhibitors of p21 ras farnesyltransferase. Other modifications including alternative spacers for AMBA, and replacement of the A.sub.1 A.sub.2 X component of known CA.sub.1 A.sub.2 X tetrapeptides by a non-peptide aryl or heterocyclic component are also disclosed as are various phosphonylated and arylated derivatives of peptides and peptidomimetics. Pro-drugs made by functionalizing terminal amino and carboxylic acid groups of peptides and peptidomimetics are also disclosed. Such functionalized derivatives demonstrate increased cell uptake. Other structural modifications are also referred to.