Patents by Inventor Andrew M. Rubino
Andrew M. Rubino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5908616Abstract: Basic aluminum halides and nitrates having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder, (b) an aluminum halide or nitrate solution and (c) water at a temperature greater than about 85.degree. C. This reaction is maintained until reaction products having an Al:anion ratio of about 1.2 to 1.8 and a solution solids concentration of about 30-40 wt. % on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography Test Band having a relative retention time corresponding to Band II of a Standard Basic Aluminum Chloride Size Exclusion Chromatogram and a Band II percent aluminum value of at least about 50% and a Band III percent aluminum value of less than 20%.Type: GrantFiled: February 16, 1998Date of Patent: June 1, 1999Assignee: Reheis Inc.Inventors: Jawahar C. Parekh, Andrew M. Rubino
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Patent number: 5718876Abstract: Basic aluminum halides and nitrates having enhanced antiperspirant efficacy are produced by reacting (a) aluminum powder, (b) an aluminum halide or nitrate solution and (c) water at a temperature greater than about 85.degree. C. This reaction is maintained until reaction products having an Al:anion ratio of about 1.2 to 1.8 and a solution solids concentration of about 30-40 wt. % on an anhydrous basis are obtained. The products are characterized as having a Size Exclusion Chromatography Test Band having a relative retention time corresponding to Band II of a Standard Basic Aluminum Chloride Size Exclusion Chromatogram and a Band II percent aluminum value of at least about 50% and a Band III percent aluminum value of less than 20%.Type: GrantFiled: April 19, 1996Date of Patent: February 17, 1998Assignee: Reheis Inc.Inventors: Jawahar C. Parekh, Andrew M. Rubino
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Patent number: 5558858Abstract: Adsorptive, protein-binding aluminum oxyhydroxides are prepared by mixing carbonate-free, highly hydrated, aluminum oxyhydroxide containing aqueous suspensions with water soluble additives that furnish coordinating moieties with the aluminum compound and drying the resultant mixture. The protein-binding aluminum oxyhydroxides can be made resuspendable by acidifying to a pH value of between about 4 and about 6.5. Such acidification can occur either before or after drying.Type: GrantFiled: September 17, 1990Date of Patent: September 24, 1996Assignee: Reheis, Inc.Inventors: Andrew M. Rubino, Arthur A. Siciliano
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Patent number: 5234677Abstract: Two-thirds to five-sixths basic aluminum chlorides having enhanced antiperspirant efficacy are produced by heating an aqueous solution containing about 40 to about 50 weight percent of the basic aluminum chloride to a temperature of at least about 130 degrees C. for about one to twelve hours in a closed vessel, with the heating time being inversely proportional to the temperature. Five-sixths basic aluminum chlorides treated in this manner are characterized by a size exclusion chromatogram having a single major peak with its apex at a relative retention time of about 0.75-0.79. The basic aluminum chlorides may be incorporated into any of the conventional antiperspirant forms with non-toxic, dermatologically acceptable carriers.Type: GrantFiled: July 2, 1990Date of Patent: August 10, 1993Assignee: Reheis Inc.Inventors: Robert W. Murray, Roger E. Nelson, Andrew M. Rubino
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Patent number: 4434155Abstract: Basic aluminum bromides having a basicity of about 5/6 have been found to be readily soluble in cosmetic solvents such as anhydrous ethanol, to have a high degree of compatibility with halogenated hydrocarbons, and to have excellent astringent characteristics. These properties make the 5/6 basic aluminum bromides particularly suitable for use in anti-perspirant compositions, especially the aerosol sprays.Type: GrantFiled: November 9, 1970Date of Patent: February 28, 1984Assignee: Armour Pharmaceutical CompanyInventors: John L. Jones, Andrew M. Rubino
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Patent number: 4223010Abstract: Basic zirconium gels may be used to form complexes with conventional aluminum and/or zirconium antiperspirant systems. The freshly prepared basic zirconium gels provide both a buffer for the highly acidic aluminum-zirconium complexes and an additional source of zirconium as an active ingredient in the antiperspirant. The preferred basic zirconium gels are basic zirconium-amino acid compounds, particularly basic zirconium glycinates, and the compounds are preferably added to aluminum-zirconium systems in the form of a wet gel. The preferred basic zirconium glycinate is formed by first reacting sodium carbonate with glycine, and then reacting the resulting sodium glycinate with a zirconium oxy or zirconium hydroxy compound to precipitate out the zirconium basic glycinate gel. Zirconium basic carbonates, prepared by reacting sodium carbonate with a zirconium oxy or hydroxy salt, are useful in preparing antiperspirant complexes with lower basic aluminum chlorides (e.g.Type: GrantFiled: January 8, 1979Date of Patent: September 16, 1980Assignee: Armour Pharmaceutical CompanyInventors: Andrew M. Rubino, John L. Jones, Edward S. Bretschneider
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Patent number: 4148812Abstract: Basic zirconium gels may be used to form complexes with conventional aluminum and/or zirconium antiperspirant systems. The freshly prepared basic zirconium gels provide both a buffer for the highly acidic aluminum-zirconium complexes and an additional source of zirconium as an active ingredient in the antiperspirant. The preferred basic zirconium gels are basic zirconium-amino acid compounds, particularly basic zirconium-glycinates, and the compounds are preferably added to aluminum-zirconium systems in the form of a wet gel. The preferred basic zirconium glycinate is formed by first reacting sodium carbonate with glycine, and then reacting the resulting sodium glycinate with a zirconium oxy or zirconium hydroxy compound to precipitate out the zirconium basic glycinate gel. The various complexes of the invention may be used in conventional antiperspirant forms, including aqueous solutions, aerosol sprays, powder-in-oil aerosol sprays, creams, lotions, cream sticks, etc.Type: GrantFiled: February 1, 1977Date of Patent: April 10, 1979Assignee: Armour Pharmaceutical CompanyInventors: Andrew M. Rubino, John L. Jones, Edward S. Bretschneider
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Patent number: 4137306Abstract: Improved antiperspirant stick compositions are provided which comprise a substantially anhydrous, homogeneous mixture of an alcohol soluble astringent basic aluminum compound as the active ingredient in a solid or semi-solid system including an alkylene polyhydric alcohol, a normally solid higher fatty acid amide of an alkylolamine in which the fatty acid radical contains at least 12 carbon atoms and the alkylol groups of the alkylolamine contain from 2 to 3 carbon atoms, and a non-toxic dermatologically acceptable non-aqueous solvent, such as ethanol, for the astringent basic aluminum compound. The mixture provides a highly esthestic, stable and quite effective antiperspirant in stick form suitable for application to the human axilla.Type: GrantFiled: June 5, 1973Date of Patent: January 30, 1979Assignee: Armour Pharmaceutical CompanyInventors: Andrew M. Rubino, John J. Margres
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Patent number: 4115553Abstract: Antacid tablets prepared by codrying certain basic aluminum bicarbonate-carbonate compositions with di- or trihydroxy alcohols suitable for oral ingestion, to obtain a powder material, and forming such a material suitably along with tablet forming ingredients into tablets which have superior mouth feel and which yield faster reaction velocities than prior antacid tablets.Type: GrantFiled: June 24, 1974Date of Patent: September 19, 1978Assignee: Armour Pharmaceutical CompanyInventors: Andrew M. Rubino, Jack J. Margres
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Patent number: 4112072Abstract: Antacid compositions prepared by drying a wet, compressed aluminum hydroxide gel to solid form which are capable of being readily resuspended to yield an opaque, aqueous suspension which reflects the properties of the original compressed gel, are produced by codrying a hydrous, gelatinous aluminum hydroxide material with a di- or trihydroxy alcohol.Type: GrantFiled: December 10, 1973Date of Patent: September 5, 1978Assignee: Armour Pharmaceutical CompanyInventors: Andrew M. Rubino, Jack J. Margres
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Patent number: 4028390Abstract: Basic zirconium gels may be used to form complexes with conventional aluminum and/or zirconium antiperspirant systems. The freshly prepared basic zirconium gels provide both a buffer for the highly acidic aluminum-zirconium complexes and an additional source of zirconium as an active ingredient in the antiperspirant. The preferred basic zirconium gels are basic zirconium-amino acid compounds, particularly basic zirconium glycinates, and the compounds are preferably added to aluminum-zirconium systems in the form of a wet gel. The preferred basic zirconium glycinate is formed by first reacting sodium carbonate with glycine, and then reacting the resulting sodium glycinate with a zirconium oxy or zirconium hydroxy compound to precipitate out the zirconium basic glycinate gel. The various complexes of the invention may be used in conventional antiperspirant forms, including aqueous solutions, aerosol sprays, powder-in-oil aerosol sprays, creams, lotions, cream sticks, etc.Type: GrantFiled: March 26, 1975Date of Patent: June 7, 1977Assignee: Armour Pharmaceutical CompanyInventors: Andrew M. Rubino, John L. Jones, Edward S. Bretschneider
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Patent number: 4025615Abstract: Alkali metal and ammonium zirconyl carbonates (AZC) may be used as active antiperspirant ingredients when converted to complexes with various acidic antiperspirant agents, including particularly the highly acidic zirconium compounds. The acidic antiperspirant agent activates the zirconium in the zirconyl carbonate to an acidic, active antiperspirant species. The zirconyl carbonate comprises about 2 to 35 weight percent of the complex, and the antiperspirant activating agent is present in such an amount that the pH of a 5 to 20 weight percent aqueous solution of the complex will be about 3 to 6. Potassium and ammonium zirconyl carbonates are preferred, but sodium may also be used if the complex is kept in solution. The acidic, antiperspirant activating agent is preferably a zirconium oxy salt or zirconium hydroxy salt, such as a zirconium hydroxy halide. However, other water soluble, polyvalent metal salts of strong acids may be used, particularly aluminum halides and basic aluminum compounds.Type: GrantFiled: February 25, 1975Date of Patent: May 24, 1977Assignee: Armour Pharmaceutical CompanyInventor: Andrew M. Rubino
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Patent number: 4021536Abstract: Astringent compositions useful as antiperspirants are provided by forming a complex of a magnesium salt and an astringent zirconium compound, particularly zirconium oxy and hydroxy salts, such that the weight ratio of the zirconium content to the magnesium content in the complex expressed as the oxides will be in the range of about 30:1 to 1:1. The preferred amount of magnesium, expressed as the oxide, in an aqueous antiperspirant solution containing an effective amount of the complex will be greater than about 3 weight percent. Preferred compositions include complexes of magnesium-amino acid salts, such as magnesium glycinate, plus zirconyl hydroxy chloride in which the ratio of zirconium to magnesium is about 10:1 to 3:1 and the total content of magnesium plus zirconium is about 5 to 15 weight percent and preferably about 5 to 10 weight percent, both expressed as the oxides. Buffers such as urea, amino acids, salts of amino acids, etc.Type: GrantFiled: April 18, 1975Date of Patent: May 3, 1977Assignee: Armour Pharmaceutical CompanyInventor: Andrew M. Rubino
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Patent number: 4021398Abstract: Staining and discoloration of painted wood surfaces, as a result of bleeding into the top or finish coat of soluble coloring matter and tannins naturally present in the wood, is prevented by coating or impregnating the wood with a basic aluminum compound, particularly with a water soluble basic aluminum halide or derivative thereof. The basic aluminum compound may be applied in aqueous solution or non-pigmented emulsion for prefinishing building lumber, or applied in the form of a pigmented emulsion as a primer coat.The present invention relates to novel methods and compositions for application to the surfaces of woods, particularly to stain-susceptible woods, to prevent their staining or discoloring as a result of tannin and tocopherol or other waste-soluble coloring matter present in the raw wood, bleeding or migrating into a subsequently applied preservative or decorative paint film.Type: GrantFiled: April 18, 1975Date of Patent: May 3, 1977Assignee: Armour Pharmaceutical CompanyInventors: William S. Gilman, John L. Jones, Andrew M. Rubino
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Patent number: 4017599Abstract: Anti-perspirant complexes are provided which comprise a combination of a basic aluminum compound, a zirconium compound and an amino compound which may be an alkaline or hydroxy salt of an amino acid in which the number of amino groups is equal to the number of carboxyl groups in the molecule. The various components are present in the complex in amounts such that the Al/Zr mol ratio is about 10:1 to 1:10 and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) is at least about 3. The basic aluminum compound may be any of the usual basic aluminum anti-perspirant salts, particularly the basic aluminum halides, and the zirconium compound may be a zirconium oxy salt and/or zirconium hydroxy salt. The amino salts may be soluble or insoluble, and particularly preferred compounds include the alkaline and alkaline earth glycinates, aluminum dihydroxy or monohydroxy glycinates, and aluminum-magnesium-hydroxy-glycinate compounds.Type: GrantFiled: November 23, 1973Date of Patent: April 12, 1977Assignee: Armour Pharmaceutical CompanyInventor: Andrew M. Rubino
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Patent number: 3998788Abstract: Unusually effective anti-perspirant compositions are provided by forming an astringent complex of a basic aluminum compound, a zirconium compound and a trace amount of an alkaline earth metal salt. The alkaline earth metal may be either calcium or magnesium or both, but preferably magnesium, and may be added as any of the usual salts such as halides, carbonate, oxide, hydroxide, etc. The basic aluminum compounds may be any of the usual basic aluminum anti-perspirant salts, particularly basic aluminum halides, and the zirconium compound may be a zirconium oxy salt and/or zirconium hydroxy salt. The complex should have an Al/Zr mole ratio of about 10:1 to 1:10, and preferably about 4:1 to 1:1, and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) should be at least about 3.Type: GrantFiled: July 17, 1974Date of Patent: December 21, 1976Assignee: Armour Pharmaceutical CompanyInventor: Andrew M. Rubino
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Patent number: 3991176Abstract: Anti-perspirant complexes are provided which comprise a combination of a basic aluminum compound, a zirconium compound and a hydroxy carboxylic compound which may be a non-toxic salt of a hydroxy carboxylic acid, a non-toxic salt of an aluminum chelate of a hydroxy carboxylic acid, a codried mixture of aluminum hydroxide with a non-toxic salt of an aluminum chelate of a hydroxy carboxylic acid, or mixtures thereof. The various components are present in the complex in amounts such that the Al/Zr mol ratio is about 10:1 to 1:10 and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) is at least about 3. The complexes may be used in conventional anti-perspirant forms, including aqueous solutions, aerosol sprays (including powder-in-oil aerosol sprays), as well as creams, lotions and cream sticks.Type: GrantFiled: January 16, 1974Date of Patent: November 9, 1976Assignee: Armour Pharmaceutical CompanyInventor: Andrew M. Rubino
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Patent number: 3981986Abstract: Water soluble anti-perspirant complexes are provided which comprise a combination of a basic aluminum-polyol compound, a zirconium compound and an organic buffer which may be urea, an amino acid in which the number of amino groups is equal to the number of carboxyl groups in the molecule, an alkaline or hydroxy salt of such amino acid, or mixtures thereof. The various components are present in the complex in amounts such that the Al/Zr mol ratio is about 10:1 to 1:10 and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) is at least about 3. The basic aluminum-polyol compounds may be those described in U.S. Pat. Nos. 3,359,169; 3,420,932; 3,405,153 and 3,555,146, particularly basic aluminum chloride-propylene glycol complex. The zirconium compound may be a zirconium oxy (zirconyl) salt and/or zirconium hydroxy salt. Preferred amino acid buffers include glycine and .beta.Type: GrantFiled: January 8, 1974Date of Patent: September 21, 1976Assignee: Armour Pharmaceutical CompanyInventor: Andrew M. Rubino
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Patent number: 3979510Abstract: Anti-perspirant complexes are provided which comprise a combination of a basic aluminum compound, a zirconium compound and a complex aluminum buffering compound containing in addition to aluminum two or more of the following: magnesium, calcium, sodium, carbonate, sulfate, hydroxyl and water. The various components are present in the complex in amounts such that the Al/Zr mole ratio is about 10:1 to 1:10 and the pH of an aqueous solution containing 5 to 15 weight percent of the complex (based on the oxides of aluminum and zirconium) is at least about 3. The basic aluminum compound may be any of the usual basic aluminum anti-perspirant salts, particularly the basic aluminum halides, and the zirconium compound may be a zirconium oxy salt and/or zirconium hydroxy salt. The complex aluminum buffer preferably contains among the additional groups or elements magnesium and/or carbonate.Type: GrantFiled: June 7, 1974Date of Patent: September 7, 1976Assignee: Armour Pharmaceutical CompanyInventor: Andrew M. Rubino
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Patent number: 3947557Abstract: Alcohol soluble complexes of basic aluminum bromides may be prepared by adding zirconyl or zinc bromide or chloride, or zirconyl hydroxychloride or hydroxybromide, or mixtures of the above chlorides and bromides to an aqueous solution of five-sixths basic aluminum bromide, and drying the resulting mixture to a substantially friable solid, such as by vacuum or spray drying. The complexes preferably have an Al/Zn or Al/Zr mol ratio of about 3:1 to 20:1, and the complex solids preferably contain about 15 to 30 weight percent water by Karl Fischer analysis. Such complex solids have a high degree of solubility in anhydrous alcohol and a high compatibility with halogenated hydrocarbons. These properties make the complexes suitable for aerosol formulations and particularly antiperspirant compositions.Type: GrantFiled: June 3, 1975Date of Patent: March 30, 1976Assignee: Armour Pharmaceutical CompanyInventors: John L. Jones, Andrew M. Rubino, Charles B. Lindahl