Patents by Inventor Andrew P. McMahon
Andrew P. McMahon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8574837Abstract: The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also selectively labeling the membrane portion of the protein with another visual marker, such that upon exposure of the cell to a stimulus, the translocation of the cell membrane-associated protein may be observed directly.Type: GrantFiled: December 29, 2009Date of Patent: November 5, 2013Assignee: President and Fellows of Harvard CollegeInventors: Yu Wang, Andrew P. McMahon
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Publication number: 20130085096Abstract: The present application relates to a method for modulating the growth state of an lung tissue, or a cell thereof, e.g., by ectopically contacting the tissue, in vitro or in vivo, with a hedgehog therapeutic, a ptc therapeutic, or an FGF-10 therapeutic in an amount effective to alter the rate (promote or inhibit) of proliferation of cells in the lung tissue, e.g., relative to the absence of administeration of the hedgehog therapeutic or ptc therapeutic. The subject method can be used, for example, to modulate the growth state of epithelial and/or mesenchymal cells of a lung tissue, such as may be useful as part of a regimen for prevention of a disease state, or in the treatment of an existing disease state or other damage to the lung tissue.Type: ApplicationFiled: August 30, 2012Publication date: April 4, 2013Applicant: President and Fellows of Harvard CollegeInventors: Carmen Pepicelli, Paula Lewis, Andrew P. McMahon
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Publication number: 20110319286Abstract: The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also selectively labeling the membrane portion of the protein with another visual marker, such that upon exposure of the cell to a stimulus, the translocation of the cell membrane-associated protein may be observed directly.Type: ApplicationFiled: December 29, 2009Publication date: December 29, 2011Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Yu Wang, Andrew P. McMahon
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Publication number: 20110124580Abstract: The present application relates to a method for modulating the growth state of an lung tissue, or a cell thereof, e.g., by ectopically contacting the tissue, in vitro or in vivo, with a hedgehog therapeutic, a ptc therapeutic, or an FGF-10 therapeutic in an amount effective to alter the rate (promote or inhibit) of proliferation of cells in the lung tissue, e.g., relative to the absence of administration of the hedgehog therapeutic or ptc therapeutic. The subject method can be used, for example, to modulate the growth state of epithelial and/or mesenchymal cells of a lung tissue, such as may be useful as part of a regimen for prevention of a disease state, or in the treatment of an existing disease state or other damage to the lung tissue.Type: ApplicationFiled: March 22, 2010Publication date: May 26, 2011Applicant: President and Fellows of Harvard CollegeInventors: Carmen V. Pepicelli, Paula M. Lewis, Andrew P. McMahon
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Patent number: 7901686Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: August 3, 2005Date of Patent: March 8, 2011Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Clifford Tabin, Valeria Marigo, Philip W. Ingham, Andrew P. McMahon
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Patent number: 7781215Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: December 5, 2006Date of Patent: August 24, 2010Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
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Patent number: 7691593Abstract: The present application relates to a method for modulating the growth state of an lung tissue, or a cell thereof, e.g., by ectopically contacting the tissue, in vitro or in vivo, with a hedgehog therapeutic, a ptc therapeutic, or an FGF-10 therapeutic in an amount effective to alter the rate (promote or inhibit) of proliferation of cells in the lung tissue, e.g., relative to the absence of administration of the hedgehog therapeutic or ptc therapeutic. The subject method can be used, for example, to modulate the growth state of epithelial and/or mesenchymal cells of a lung tissue, such as may be useful as part of a regimen for prevention of a disease state, or in the treatment of an existing disease state or other damage to the lung tissue.Type: GrantFiled: December 3, 2003Date of Patent: April 6, 2010Assignee: President and Fellows of Harvard CollegeInventors: Carmen Pepicelli, Paula Lewis, Andrew P. McMahon
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Patent number: 7585671Abstract: The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.Type: GrantFiled: May 22, 2006Date of Patent: September 8, 2009Assignee: President and Fellows of Harvard CollegeInventors: Andrew P. McMahon, Pao-Tien Chuang
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Publication number: 20080171328Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: August 20, 2007Publication date: July 17, 2008Applicants: The President and Fellows of Harvard College, Imperial Cancer Research Technology LimitedInventors: Clifford Tabin, Valeria Marigo, Philip W. Ingham, Andrew P. McMahon
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Patent number: 7144732Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: April 28, 2004Date of Patent: December 5, 2006Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology InstituteInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
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Patent number: 7115394Abstract: The present invention concerns the discovery of a new family of hedgehog binding proteins, refered to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.Type: GrantFiled: November 4, 2002Date of Patent: October 3, 2006Assignee: President and Fellows of Harvard CollegeInventors: Andrew P. McMahon, Pao-Tien Chuang
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Patent number: 7060450Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: November 13, 2000Date of Patent: June 13, 2006Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Clifford Tabin, Valeria Marigo, Philip W. Ingham, Andrew P. McMahon
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Patent number: 6884775Abstract: The present application is directed to the discovery that hedgehog proteins, and agents which effect the activities thereof, can be used to control the formation and/or maintenance of cartilage and bone.Type: GrantFiled: August 1, 1997Date of Patent: April 26, 2005Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology, Inc.Inventors: Clifford J. Tabin, Andrew P. McMahon, Philip W. Ingham, Andrea M. Vortkamp
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Publication number: 20040224882Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: August 25, 2003Publication date: November 11, 2004Applicants: Imperial Cancer Research Technology Limited, President and Fellows of Harvard CollegeInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
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Publication number: 20040171546Abstract: The present application relates to a method for modulating the growth state of an lung tissue, or a cell thereof, e.g., by ectopically contacting the tissue, in vitro or in vivo, with a hedgehog therapeutic, a ptc therapeutic, or an FGF-10 therapeutic in an amount effective to alter the rate (promote or inhibit) of proliferation of cells in the lung tissue, e.g., relative to the absence of administeration of the hedgehog therapeutic or ptc therapeutic. The subject method can be used, for example, to modulate the growth state of epithelial and/or mesenchymal cells of a lung tissue, such as may be useful as part of a regimen for prevention of a disease state, or in the treatment of an existing disease state or other damage to the lung tissue.Type: ApplicationFiled: December 3, 2003Publication date: September 2, 2004Applicant: President and Fellows of Harvard CollegeInventors: Carmen V. Pepicelli, Paula M. Lewis, Andrew P. McMahon
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Patent number: 6664075Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: December 13, 2000Date of Patent: December 16, 2003Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
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Publication number: 20030190696Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: December 13, 2000Publication date: October 9, 2003Applicant: President and Fellows of Harvard CollegeInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin, David A. Bumcrot, Elisa Marti-Gorostiza
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Patent number: 6630148Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: October 20, 1997Date of Patent: October 7, 2003Assignees: Imperial Cancer Research Technology Ltd., President and Fellows of Harvard CollegeInventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin
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Publication number: 20030186357Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: ApplicationFiled: June 5, 1995Publication date: October 2, 2003Inventors: PHILIP W. INGHAM, ANDREW P. MCMAHON, CLIFFORD J. TABIN
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Patent number: 6610656Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.Type: GrantFiled: October 20, 1997Date of Patent: August 26, 2003Assignees: President and Fellows of Harvard College, Imperial Cancer Research Technology, Ltd.Inventors: Philip W. Ingham, Andrew P. McMahon, Clifford J. Tabin