Patents by Inventor Andrew Shiau

Andrew Shiau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200383990
    Abstract: Provided herein, inter alia, are compounds and methods for inhibiting PLK4 and for treating cancer in a subject in need thereof.
    Type: Application
    Filed: December 6, 2018
    Publication date: December 10, 2020
    Inventors: Karen Oegema, Andrew Shiau, Arshad Desai, Franz Meitinger, Robert Davis
  • Patent number: 10752612
    Abstract: Provided herein, inter alia, are compounds and methods for inhibiting PLK4 and for treating cancer in a subject in need thereof.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: August 25, 2020
    Assignee: LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
    Inventors: Timothy Gahman, Andrew Shiau
  • Publication number: 20200237763
    Abstract: Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FEN1), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXO1) and/or GEN1.
    Type: Application
    Filed: September 26, 2016
    Publication date: July 30, 2020
    Inventors: Timothy Gahman, Andrew Shiau, Richard Kolodner
  • Publication number: 20180086739
    Abstract: Provided herein, inter alia, are compounds and methods for inhibiting PLK4 and for treating cancer in a subject in need thereof.
    Type: Application
    Filed: April 15, 2016
    Publication date: March 29, 2018
    Inventors: Timothy Gahman, Andrew Shiau
  • Publication number: 20080027112
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 31, 2008
    Inventors: Steven Govek, Andrew Shiau, Stewart Noble, David Thomas
  • Publication number: 20080027099
    Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
    Type: Application
    Filed: July 6, 2007
    Publication date: January 31, 2008
    Inventors: Steven Govek, Andrew Shiau, Stewart Noble, David Thomas
  • Publication number: 20070270434
    Abstract: The present invention relates to compounds and methods useful as inhibitors of PPAR, particularly PPAR?, and for the treatment or prevention of PPAR-mediated diseases, including metabolic diseases.
    Type: Application
    Filed: May 16, 2007
    Publication date: November 22, 2007
    Applicant: KALYPSYS, INC.
    Inventors: James W. Malecha, Stewart A. Noble, Sergio G. Duron, Andrew Lindstrom, Andrew Shiau, Steven Govek
  • Publication number: 20070190079
    Abstract: The present invention relates to methods of selective modulation of peroxisome proliferator activated receptors (PPARs) over G-protein coupled receptor 40 (GPR40), and the use of therapeutically effective amounts of compounds and pharmaceutical compositions which selectively modulate PPAR over GPR40 for the treatment of diseases in patients in need thereof. The methods disclosed herein are exceptionally useful in treating metabolic diseases whilst avoiding certain side effects common to modulators of PPAR previously disclosed in the art.
    Type: Application
    Filed: March 19, 2007
    Publication date: August 16, 2007
    Applicant: KALYPSYS, INC.
    Inventors: Andrew Shiau, Mark Massari, Guy Oshiro, Ayman Kabakibi, James Malecha, Stewart Noble
  • Publication number: 20060270718
    Abstract: Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
    Type: Application
    Filed: August 8, 2006
    Publication date: November 30, 2006
    Inventors: Xian Jiao, Frank Kayser, David Kopecky, Sharon McKendry, Derek Piper, Andrew Shiau
  • Publication number: 20060205736
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: May 16, 2006
    Publication date: September 14, 2006
    Inventors: Stewart Noble, Guy Oshiro, James Malecha, Cunxiang Zhao, Sergio Duron, Andrew Lindstrom, Andrew Shiau, Boliang Lou, Steven Govek, David Thomas
  • Publication number: 20060167012
    Abstract: Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: October 25, 2005
    Publication date: July 27, 2006
    Inventors: Stewart Noble, Guy Oshiro, James Malecha, Cunxiang Zhao, Carmen Robinson, Sergio Duron, Michael Sertic, Andrew Lindstrom, Andrew Shiau, Christopher Bayne, Mehmet Kahraman, Boliang Lou, Steven Govek
  • Publication number: 20060122239
    Abstract: Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
    Type: Application
    Filed: January 17, 2006
    Publication date: June 8, 2006
    Inventors: Xian Jiao, Frank Kayser, Sharon McKendry, Derek Piper, Andrew Shiau
  • Publication number: 20050234046
    Abstract: Aryl sulfonamide and sulfonyl compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 20, 2005
    Applicant: Kalypsys, Inc.
    Inventors: Cunxiang Zhao, James Malecha, Stewart Noble, Sergio Duron, Andrew Lindstrom, Andrew Shiau