Abstract: A method for printing onto a substrate is disclosed. An ink is printed onto a liquid polymer layer to form a printed polymer layer. Printed substrates are also disclosed.

Abstract: Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

Abstract: Methods for developing engineered T-cells for immunotherapy that are both non-alloreactive and resistant to immunosuppresive drugs. The present invention relates to methods for modifying T-cells by inactivating both genes encoding target for an immunosuppressive agent and T-cell receptor, in particular genes encoding CD52 and TCR. This method involves the use of specific rare cutting endonucleases, in particular, TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection. of key genes in T-cells, which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.

Abstract: The present application relates generally to filter media useful for manufacturing air filters for residential and commercial office's Heating, Ventilation, and Air Conditioning (HVAC), particularly to filters and filter media comprising soybean-based materials. The present invention provides an inexpensive, effective, environmentally friendly, and sustainable media for manufacturing HVAC air filters for residential and commercial buildings.

Abstract: Processes for converting one or more C1-C5 linear or branched alcohols to one or more C2-C5 olefins are provided. In one exemplary embodiment, the process can be a single stage process for the direct conversion of C1-C5 alcohols to olefinic mixtures (e.g., C2-C5) carried out in a reactor using a catalyst that includes zeolite doped with boron and phosphor. Systems for carrying out these processes are also provided.

Abstract: An internal multi-function rearview device for use with a vehicle includes a rearview element comprising at least one of a reflective element, a camera, or a display element; a housing configured to be attached to the vehicle and configured to be moveable relative to the vehicle; a bezel configured to be affixed to an opening defined by the housing and configured to surround the rearview element; and a foot configured to be fixed to the vehicle and relative to which the housing and bezel is moveable. The bezel is coated and a coating of the bezel is at least one of a decorative coating, an advanced surface technology, or a spectrally controlling system, and the rearview element is coupled to at least one of the bezel or the housing.

Abstract: Wellbore synthesis techniques are disclosed suitable for use in geothermal applications. Embodiments are provided where open hole drilled wellbores are sealed while drilling to form an impervious layer at the wellbore/formation interface. The techniques may be chemical, thermal, mechanical, biological and are fully intended to irreversibly damage the formation in terms of the permeability thereof. With the permeability negated, the wellbore may be used to create a closed loop surface to surface geothermal well operable in the absence of well casing for maximizing thermal transfer to a circulating working fluid. Formulations for the working and drilling fluids are disclosed.

Abstract: The present invention provides an encrypting device including an encryption unit and a communications unit. Paired encrypting devices allow for communication of trusted data between trusted devices over an untrusted network. Data received by the encryption unit is encrypted and provided with a connectionless header for delivery to the communications unit. Data received by the communications units is provided with a complex header for delivery to the paired encrypting device. The encrypting devices may be implemented in hardware or may be virtualized on a server or a plurality of severs. Arrangement of the encrypting devices in a hub-and-spoke topology allows for communication amongst a plurality of trusted devices. The encrypting devices can be used to covert commercially available equipment suitable for high assurance environments.

Abstract: A system is disclosed for additively manufacturing a composite structure. The system may include a support, and a print head operatively connected to and moveable by the support. The print head may include an outlet configured to discharge a material in a trajectory along a central axis of the outlet; a compactor disposed downstream of the outlet relative to the trajectory and configured to press the material transversely against an adjacent surface, and a cutting module located between the outlet and the compactor. The compactor and the cutting module may be configured to move together relative to the outlet.

Abstract: A three-dimensional print head apparatus comprising a hopper, a nozzle, a barrel, a heating system, a fume extraction system, a dry air purge system, and an agitator. The hopper may having a cavity and may have a lower aperture. The nozzle may have an upper aperture and may have a lower aperture. The heating system may be positioned along at least a portion of the barrel, which may defined a heated zone of the barrel. The dry air purge system may be in fluid communication with the hopper. The agitator may have at least one paddle.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: A biopsy device includes a body, a needle, a cutter, an analysis area, a valve, and a tissue sample holder. The cutter is movable relative to the needle and in communication with the needle for transporting tissue samples. The analysis area is disposed proximally of the cutter and in communication with the needle to receive a tissue sample cut by the cutter for analysis by a user. The valve is disposed proximally of the analysis area and configured to alternate between an open configuration and a closed configuration. The tissue sample holder is disposed proximally of the valve and fixedly attached to the body. The valve is configured to permit analysis of the sample disposed in the analysis area when the valve is in the closed configuration and to permit the tissue sample to be passed into the tissue sample holder when the valve is in the open configuration configuration.

Abstract: A system for alerting motorists travelling on a roadway in a vicinity of a vehicle is disclosed. The system includes one or more projector units, and a respective attachment structure for each of the one or more projector units for attaching the projector units to a portion of the vehicle. The one or more projector units are configured and arranged to project a light signal on to at least a portion of the roadway adjacent the vehicle and in a travel path of the motorist. The one or more projector units include at least one light flare projector unit and/or at least one signage projector unit. A school bus incorporating the system is also disclosed. A method for alerting motorists travelling on a roadway in the vicinity of a vehicle is also disclosed.

Abstract: A device for cutting a filament of a 3D printer includes a blade having a first end and a second end opposite the first end. The device also includes a support that is attachable to a heater block of the 3D printer and supports the blade, such that the blade is movable relative to the heater block. The first end of the blade is a cutting end, and the second end of the blade is a drive end. The drive end of the blade has a surface configured to receive a force from outside of the device, such that the blade moves relative to the heater block.

Abstract: A vehicle seating system includes a support feature coupled to a sidewall within a cargo space of a vehicle. A seating assembly is coupled to the support feature. The seating assembly is rotatable between a stowed position and a deployed position. The seating assembly includes a seat base having a proximal end coupled to the support feature and a distal end. The distal end of the seat base is disposed adjacent to the sidewall in the stowed position. The seating assembly also includes a leg support coupled to the distal end of the seat base. The leg support is operable between a storage position and a support position.

Abstract: Apparatus and methods for managing pain uses a multiplexed modulation/stimulation signal to provide pain relief during spinal cord stimulation or peripheral nerve stimulation.

Abstract: A process where a liquid or supercritical CO2 co-solvent is used in a hydrothermal liquefaction (HTL) process. The process improves yield of the HTL process.

Abstract: An optical sub-assembly includes a housing; at least one component integrated within the housing, wherein the at least one component is configured to generate heat during operation; and a heat spreader integrated as part of the housing or integrated within the housing. The heat spreader is thermally coupled to the at least one component to receive heat from the at least one component. The heat spreader contains a phase change material that is configured to undergo phase transitions between a first phase state and a second phase state. The heat spreader is configured to utilize the phase transitions to spread heat throughout the heat spreader. The heat spreader is configured to equalize a heat load or minimize a temperature gradient of the optical sub-assembly.

Abstract: Systems and methods for providing adaptive and interactive AI-driven profiles ingest brand content data; organize the data into embeds and indexes; store the plurality of embeds and indexes in a knowledge base; generate a user profile based on the organized embeds and indexes, and a user history of a user associated with the user profile; update the user profile based on interactions between the user and the user profile, and one or more models trained on records indicative of one or more processes of human users; personalize responses of a conversational agent interacting with the first user based on the first user profile; provide the customized content recommendations to the user; and provide data-driven recommendations regarding improvements to responses of respective conversational agents, improvements to one or more services provided, and system performance.