Abstract: A fluid dispenser including a body, a chamber coupled to or formed as part of the body and configured to contain a quantity of fluid, and a piston coupled to the body and rotatable within the chamber to different position. The piston is movable relative to the chamber in a first direction along an axis to draw fluid into the chamber, and the piston is movable relative to the chamber in a second direction opposite the first direction to discharge fluid from the chamber. The piston has stroke lengths that are selectable via the different rotational positions of the piston and that are associated with metered quantities of fluid to be drawn into the chamber. An anti-reversal feature is disposed between the piston and the body. The anti-reversal feature inhibits reversal of the piston during movement of the piston in the first direction or the second direction.

Abstract: A fluid dispenser including a body, a chamber coupled to or formed as part of the body and configured to contain a quantity of fluid, and a piston coupled to the body and rotatable within the chamber to different position. The piston is movable relative to the chamber in a first direction along an axis to draw fluid into the chamber, and the piston is movable relative to the chamber in a second direction opposite the first direction to discharge fluid from the chamber. The piston has stroke lengths that are selectable via the different rotational positions of the piston and that are associated with metered quantities of fluid to be drawn into the chamber. An anti-reversal feature is disposed between the piston and the body. The anti-reversal feature inhibits reversal of the piston during movement of the piston in the first direction or the second direction.

Abstract: A fluid dispenser including a body, a chamber coupled to or formed as part of the body and configured to contain a quantity of fluid, and a piston coupled to the body and rotatable within the chamber to different position. The piston is movable relative to the chamber in a first direction along an axis to draw fluid into the chamber, and the piston is movable relative to the chamber in a second direction opposite the first direction to discharge fluid from the chamber. The piston has stroke lengths that are selectable via the different rotational positions of the piston and that are associated with metered quantities of fluid to be drawn into the chamber. An anti-reversal feature is disposed between the piston and the body. The anti-reversal feature inhibits reversal of the piston during movement of the piston in the first direction or the second direction.

Abstract: A fluid dispenser including a body, a chamber coupled to or formed as part of the body and configured to contain a quantity of fluid, and a piston coupled to the body and rotatable within the chamber to different position. The piston is movable relative to the chamber in a first direction along an axis to draw fluid into the chamber, and the piston is movable relative to the chamber in a second direction opposite the first direction to discharge fluid from the chamber. The piston has stroke lengths that are selectable via the different rotational positions of the piston and that are associated with metered quantities of fluid to be drawn into the chamber. An anti-reversal feature is disposed between the piston and the body. The anti-reversal feature inhibits reversal of the piston during movement of the piston in the first direction or the second direction.

Abstract: A fluid dispenser for containing and dispensing metered amounts of fluid that includes a reservoir for containing fluid and a chamber positioned substantially within the reservoir for containing a quantity of the fluid. The fluid dispenser additionally includes a piston that is moveable within the chamber to draw fluid into the chamber when the piston is moved in a first direction with respect to the chamber, and to discharge fluid from the chamber when the piston is moved in a second direction opposite the first direction. Further, the fluid dispenser includes a user-manipulatable control coupled to the piston and rotatable about an axis to select one of at least two different metered quantities of fluid to be dispensed. The user-manipulatable control is further movable to move the piston relative to the chamber along the axis to selectively dispense the selected metered quantity of fluid.

Abstract: A fluid dispenser for containing and dispensing metered amounts of fluid that includes a reservoir for containing fluid and a chamber positioned substantially within the reservoir for containing a quantity of the fluid. The fluid dispenser additionally includes a piston that is moveable within the chamber to draw fluid into the chamber when the piston is moved in a first direction with respect to the chamber, and to discharge fluid from the chamber when the piston is moved in a second direction opposite the first direction. Further, the fluid dispenser includes a user-manipulatable control coupled to the piston and rotatable about an axis to select one of at least two different metered quantities of fluid to be dispensed. The user-manipulatable control is further movable to move the piston relative to the chamber along the axis to selectively dispense the selected metered quantity of fluid.

Abstract: A fluid dispenser for containing and dispensing metered amounts of fluid that includes a reservoir for containing fluid and a chamber positioned substantially within the reservoir for containing a quantity of the fluid. The fluid dispenser additionally includes a piston that is moveable within the chamber to draw fluid into the chamber when the piston is moved in a first direction with respect to the chamber, and to discharge fluid from the chamber when the piston is moved in a second direction opposite the first direction. Further, the fluid dispenser includes a user-manipulatable control coupled to the piston and rotatable about an axis to select one of at least two different metered quantities of fluid to be dispensed. The user-manipulatable control is further movable to move the piston relative to the chamber along the axis to selectively dispense the selected metered quantity of fluid.

Abstract: A fluid dispenser for containing and dispensing metered amounts of fluid that includes a reservoir for containing fluid and a chamber positioned substantially within the reservoir for containing a quantity of the fluid. The fluid dispenser additionally includes a piston that is moveable within the chamber to draw fluid into the chamber when the piston is moved in a first direction with respect to the chamber, and to discharge fluid from the chamber when the piston is moved in a second direction opposite the first direction. Further, the fluid dispenser includes a user-manipulatable control coupled to the piston and rotatable about an axis to select one of at least two different metered quantities of fluid to be dispensed. The user-manipulatable control is further movable to move the piston relative to the chamber along the axis to selectively dispense the selected metered quantity of fluid.

Abstract: A fluid dispenser for containing and dispensing metered amounts of fluid that includes a reservoir for containing fluid and a chamber positioned substantially within the reservoir for containing a quantity of the fluid. The fluid dispenser additionally includes a piston that is moveable within the chamber to draw fluid into the chamber when the piston is moved in a first direction with respect to the chamber, and to discharge fluid from the chamber when the piston is moved in a second direction opposite the first direction. Further, the fluid dispenser includes a user-manipulatable control coupled to the piston and rotatable about an axis to select one of at least two different metered quantities of fluid to be dispensed. The user-manipulatable control is further movable to move the piston relative to the chamber along the axis to selectively dispense the selected metered quantity of fluid.

Abstract: A fluid dispenser for containing and dispensing metered amounts of fluid that includes a reservoir for containing fluid and a chamber positioned substantially within the reservoir for containing a quantity of the fluid. The fluid dispenser additionally includes a piston that is moveable within the chamber to draw fluid into the chamber when the piston is moved in a first direction with respect to the chamber, and to discharge fluid from the chamber when the piston is moved in a second direction opposite the first direction. Further, the fluid dispenser includes a user-manipulatable control coupled to the piston and rotatable about an axis to select one of at least two different metered quantities of fluid to be dispensed. The user-manipulatable control is further movable to move the piston relative to the chamber along the axis to selectively dispense the selected metered quantity of fluid.

Abstract: A fluid dispenser contains and dispenses metered amounts of fluid, and in some embodiments comprises a reservoir for containing fluid; a chamber positioned substantially within the reservoir for containing a quantity of fluid; and a piston moveable within the chamber in a first direction to draw fluid into the chamber from the reservoir, and movable in a second direction to discharge a metered amount of fluid from the chamber. A user-manipulatable control can be coupled to the piston to move the piston with respect to the chamber, and in some cases to select the desired metered amount of fluid to be dispensed. Also, a pawl can be used to selectively permit and inhibit movement of the piston in the first and/or second directions to prevent partial doses from being dispensed from the fluid dispenser.

Abstract: A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment.

Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Abstract: The present invention is directed to therapeutic compounds which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes.

Abstract: The present invention is directed to therapeutic compounds of the following formula (I) which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes.

Abstract: The present invention is directed to therapeutic compounds which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes.

Abstract: Compounds of formula (I):or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of diabetes and obesity.

Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.