Abstract: Methods and systems for mapping a sharable resource using a one-time password are disclosed. An identifier included in a set of provided credentials uniquely associates the one-time password with an executable within a computing environment that hosts the sharable resource. When credentials are received in association with a mapping request, it is determined whether a supplied username corresponds to a user authorized to access the sharable resource and whether a representation of a supplied password received in association with the mapping request matches a representation of the one-time password. Validating the mapping request provides access to the sharable resource.

Abstract: A system and method for rolling planar food products that rest upon interleaving paper is provided. The system includes first and second conveyors, a rotating mechanism and a movement system. The rotating mechanism is normally disposed at a first position proximate to the end of the first conveyor such that a leading edge of planar dough that extends over the first conveyor falls with respect to the rotating mechanism. The controller urges rotation of the rotation mechanism as the leading edge extends with respect to the rotating mechanism and rotates until the planar food product is fully rolled about the rotation mechanism. The movement mechanism then translates the rotation mechanism to a position where it is aligned with the second conveyor.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

Abstract: Methods and systems for implementing independent time in a hosted operating environment are disclosed. The hosted, or guest, operating environment, can be seeded with a guest time value by a guest operating environment manager that maintains a time delta between a host clock time and an enterprise time. The guest operating environment can subsequently manage its guest clock from the guest time value. If the guest operating environment is halted, the guest operating environment manager can manage correspondence between the host clock time and the enterprise time by periodically assessing divergence between actual and expected values of the host clock time.

Abstract: A folding-diverter assembly is provided to: selectively divert a substrate-product combination advancing from a first direction in a predetermined path based upon the substrate-product combination weighing a predetermined weight; advance the substrate-product combination in a second direction, opposite from the first direction; and fold a flap of the substrate-product combination partially over a top surface of the substrate-product combination. A semi-circular conveyor assembly is configured to advance the substrate-product combination in the second direction at a first portion of the semi-circular conveyor assembly, and along a semi-circular advancing path such that the substrate-product combination is advanced in the first direction at a second portion of the semi-circular conveyor assembly.

Abstract: A split cycle internal combustion engine comprising a compression cylinder accommodating a compression piston; a combustion cylinder accommodating a combustion piston; a crossover passage between the compression cylinder and the combustion cylinder arranged to provide working fluid to the combustion cylinder; a controller arranged to determine a peak temperature of combustion in the combustion cylinder based on a received indication of a peak temperature of combustion in the combustion cylinder; and a coolant system arranged to regulate a temperature of the working fluid supplied to the combustion cylinder; wherein, in response to determining that the peak temperature of combustion exceeds a selected threshold, the controller is configured to control the coolant system to regulate the temperature of the working fluid supplied to the combustion cylinder so that a peak temperature of combustion in the combustion cylinder is less than the selected threshold.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: A system for interleaving substrate under food products is provided. The system includes an interleaver assembly configured to interleave substrate with food products. A programmable logic controller (PLC) includes a sensor in communication with the interleaver assembly. The sensor is configured to detect an identifier provided on each substrate stock of a plurality of substrate stocks, and each identifier is associated with an interleaving profile. The interleaver assembly interleaves the substrate with the food product according to a specific interleaving profile in response to the sensor detecting the identifier on the substrate stock.

Abstract: A substrate insertion system is configured for insertion of a substrate under a product being carried on a conveyor. A pre-perforated substrate and a method of inserting the pre-perforated substrates under products carried on a conveyor are also provided. Furthermore, a method is described including the construction and operation of a substrate insertion system.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: A method of photolithography patterning multi-colored organic light emitting diodes (OLED) for a sub 10 um pixel size range, suited for a high-definition light field display, on a single substrate with a multilayer capping layer by way of sputtering deposition for protection of organics with advanced adhesion to the substrate comprising the steps of depositing a first OLED with a capping layer then depositing a second OLED structure on the substrate using a low temperature photoresist patterning process with a capping layer.

Abstract: Systems and methods for displaying electronic messages are disclosed. In one aspect, a method is performed at a computing device. The method includes: (1) receiving a plurality of electronic messages; (2) assigning a first subset of the messages to a predefined group category based on a set of content-based clustering rules and content in respective bodies of the messages; (3) concurrently displaying a second subset of the messages and a cluster graphic corresponding to the predefined group category, where the cluster graphic includes a label that describes the predefined group category; (4) while concurrently displaying the second subset of electronic messages and the cluster graphic, receiving user selection of the cluster graphic; and (5) in response, displaying a plurality of messages in the predefined group category, including displaying at least one message from the first subset of messages.

Abstract: The invention describes, in part, improved methods, assays, and kits for detecting analytes in biological samples with magnetic particles.

Abstract: The invention described herein provides, in part, improved methods, compositions, and kits for detecting analytes in biological samples.

Abstract: Provided herein, inter alia, are improved methods for detecting analytes, including proteins and nucleic acids. In some instances, the analytes are detected in complex matrices such as serum.

Abstract: Systems and methods for displaying electronic messages are disclosed. In one aspect, a method is performed at a computing device. The method includes: (1) receiving a plurality of electronic messages; (2) assigning a first subset of the messages to a predefined group category based on a set of content-based clustering rules and content in respective bodies of the messages; (3) concurrently displaying a second subset of the messages and a cluster graphic corresponding to the predefined group category, where the cluster graphic includes a label that describes the predefined group category; (4) while concurrently displaying the second subset of electronic messages and the cluster graphic, receiving user selection of the cluster graphic; and (5) in response, displaying a plurality of messages in the predefined group category, including displaying at least one message from the first subset of messages.

Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.