Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: Appliances, such as earbuds, configured to be used in pairs or otherwise configured to be operated in communication with one another, are arranged for transferring charge from a donor appliance to a recipient appliance. For the earbud system, a first earbud includes an external contact operatively coupled to the first battery, and the second earbud includes a complementary external contact operatively coupled to the second battery. The external contact on the first earbud and the complementary external contact on the second earbud are arranged for electrical connection to provide power from the first battery on the first earbud for charging the second battery on the second earbud, so that the second earbud can act as a recipient of power from the first earbud which acts as a donor of power.

Abstract: Systems and methods for distributing computing tasks are disclosed. One system includes a first computing system and a second computing system. The first computing system includes a processing unit and a memory, the memory storing a computer-executable workload including a plurality of procedures including at least one distributable procedure, the at least one distributable procedures capable of execution independent of underlying operating system or platform resources of the first computing system and configured for execution on an architecture of the first computing system. The system further includes a distributable computation unit executable on a second computing system, the distributable computation unit including the at least one distributable procedure, a state of computing resources of the first computing system, and an application capable of execution on the second computing system to perform the at least one distributable procedure.

Abstract: This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.

Abstract: Provided herein are methods for mapping immune response to an immunogen, comprising: immunizing a subject with an immunogen and obtaining sera from the immunized subject at multiple time intervals following immunization, wherein the sera comprises one or more immune complexes between the immunogen and serum antibodies; imaging, by electron microscopy, the sera obtained from the immunized subject in each of the time intervals, to obtain structural images of the one or more immune complexes formed between the immunogen and serum antibodies; mapping immune response to the immunogen by measuring differences in structural images obtained at different time intervals to simultaneously visualize diverse antibodies targeting distinct epitopes in the immunized subjects.

Abstract: An electrophoretic device for detecting biomarkers in collected bodily fluid and methods of using the same.

Abstract: An apparatus that focuses on improving efficiency, profitability, and results in the automotive detailing and automotive paint and body shop industries, contains a first layer, a second layer, and a center layer. An inner surface of the first layer is connected to the center layer. An inner surface of the second layer is connected to the center layer opposite to the first sanding layer. The multiple tiers of the apparatus improve user control and maximizes surface contact between the apparatus and the surface being sanded. A first edge and a second edge of the first layer and the second layer can be a straight-cut edge, a bevel cut edge or a rounded edge. Thus, the apparatus can be used on a variety of surfaces. The consistency and the uniformity of the sanding patterns obtained helps the user compound and polish the sanded surface to a more refined finish.

Abstract: A method and apparatus are disclosed for retaining at least one elongate object. The apparatus includes a first retaining member (702) comprising at least one female portion (712), a further retaining member (700) comprising at least one male portion (732) receivable in the at least one female portion, wherein the at least one male portion (732) comprises a first connecting region adapted to cooperate with a further connecting region and at least one securing element (785) slidable in a keyway (775) of the first retaining member (702) and engagable with said male portion (732) to securely connect the first and further retaining members and retain an elongate object therebetween.

Abstract: A mesh network system and method for use in an area affected by a natural disaster. The system includes a first network node that has Wi-Fi capability and a first Wi-Fi coverage area. The system also includes at least one second network node, coupled to the first network node, with the at least one second network node having Wi-Fi capability and a second Wi-Fi coverage area outside of the first Wi-Fi coverage area. The first network node and the at least one second network node are coupled together via at least one radio transceiver to form a network route within the mesh network. A first communication device located within the area affected by the natural disaster and operably coupled to the first network node communicates with a second communication device located within the area affected by the natural disaster and coupled to the at least one second network node via the network route within the mesh network.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Abstract: The present invention pertains to prevention of and/or treatment for filariasis. In particular, the present invention pertains to the use of tylosin A and its analogs and derivatives to prevent or treat filarial worm infection and/or diseases associated with filarial worm infection. The present invention also pertains to pharmaceutical compositions comprising tylosin A or an analog or derivative thereof for use in preventing or treating filarial worm infection and/or diseases associated with filarial worm infection.

Abstract: An apparatus for measuring a characteristic of a sample using a centrifuge and optical components is disclosed. The centrifuge may be a standard benchtop centrifuge. The optical components may be sized and dimensioned to fit, along with the sample, inside the centrifuge.

Abstract: The present disclosure concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and R3 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cancer.

Abstract: Provided herein, in some embodiments, are methods of high-throughput screening of small molecules and related compositions and articles of manufacture.

Abstract: Systems and methods for displaying electronic messages are disclosed. In one aspect, a method is performed at a computing device. The method includes: (1) receiving a plurality of electronic messages; (2) assigning a first subset of the messages to a predefined group category based on a set of content-based clustering rules and content in respective bodies of the messages; (3) concurrently displaying a second subset of the messages and a cluster graphic corresponding to the predefined group category, where the cluster graphic includes a label that describes the predefined group category; (4) while concurrently displaying the second subset of electronic messages and the cluster graphic, receiving user selection of the cluster graphic; and (5) in response, displaying a plurality of messages in the predefined group category, including displaying at least one message from the first subset of messages.

Abstract: A method and apparatus are disclosed for retaining at least one elongate object. The apparatus includes a first retaining member (702) comprising at least one female portion (712), a further retaining member (700) comprising at least one male portion (732) receivable in the at least one female portion, wherein the at least one male portion (732) comprises a first connecting region adapted to cooperate with a further connecting region and at least one securing element (785) slidable in a keyway (775) of the first retaining member (702) and engagable with said male portion (732) to securely connect the first and further retaining members and retain an elongate object therebetween.

Abstract: The present application relates to novel HIV-1 envelope glycoproteins which may be utilized as an HIV-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.

Abstract: The present disclosure concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R1, R2 and R3 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cancer.

Abstract: Systems and methods for displaying electronic messages are disclosed. In some embodiments, a method includes, at a computing device, concurrently displaying (i) a user interface object that represents a group of messages and (ii) one or more first indicia of a number of messages that have a predefined display status, in the group of messages while foregoing displaying more than one message of the group of messages. The method also includes receiving a selection of the user interface object; and, in response to receiving the selection of the user interface object, displaying messages in the group of messages. The method further includes, in accordance with displaying the messages in the group of messages, modifying the one or more displayed first indicia of the number of messages, which have the predefined display status, in the group of messages.

Abstract: The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.